Dioridinvel pills 50mg+450mg, 60pcs

Composition

Per tablet:

Active ingredients: hesperidin-50 mg, diosmin-450 mg.

Auxiliary substances: gelatin, magnesium stearate, microcrystalline cellulose, sodium carboxymethyl starch (sodium starch glycolate, primogel), talc, purified water, opadray II 32F230011 orange (hypromellose, lactose monohydrate, titanium dioxide, macrogol-4000, iron oxide yellow dye, iron oxide red dye).

Pharmacological action

Pharmacotherapeutic group: venotonizing and venoprotective agent.

ATX code: C 05 CA 53

Pharmacological properties

Pharmacodynamics

The combination of hesperidin + diosmin has venotonizing and angioprotective properties. Reduces the dilatability of veins and venous congestion, reduces capillary permeability and increases their resistance, improves venous hemodynamics. It affects the following venous plethysmographic parameters: venous capacity, venous extensibility, and venous emptying time. The optimal effect is achieved when taking 1000 mg.

The combination of hesperidin + diosmin increases venous tone by reducing the time of venous emptying. In patients with signs of severe microcirculation disorders, an increase in capillary resistance is noted.

The combination of hesperidin + diosmin is effective in the treatment of chronic diseases of the veins of the lower extremities, as well as in the treatment of hemorrhoids.

Pharmacokinetics

The main elimination of the drug occurs through the intestines. On average, about 14% of the amount of the drug taken is excreted by the kidneys. The elimination half-life is 11 hours.

The drug undergoes active metabolism, This is confirmed by the presence of phenolic acids in the urine.

Indications

Treatment of symptoms of venous-lymphatic insufficiency:

– pain;

– cramps of the lower extremities;

– feeling of heaviness and bursting in the legs;

-” fatigue ” of the legs.

Treatment of venous-lymphatic insufficiency manifestations:

– edema of the lower extremities;

– trophic changes in the skin and subcutaneous tissue;

– venous trophic ulcers.

Symptomatic treatment of acute and chronic hemorrhoids.

Use during pregnancy and lactation

Animal experiments did not reveal any teratogenic effects.

To date, there have been no reports of adverse effects when using the drug in pregnant women.

Due to the lack of data on the excretion of the drug in breast milk, it is not recommended to take the drug during breastfeeding.

Reproductive toxicity studies have shown no effect on reproductive function in rats of both sexes.

Contraindications

Hypersensitivity, breast-feeding period. Patients with rare hereditary problems such as galactose intolerance, lactase deficiency, or glucose-galactose malabsorption syndrome.

Side effects of

the Frequency of occurrence of adverse reactions is given in accordance with the who classification: very often (>1/10); often (>1/100, <1/10); infrequently (>1/1000, <1/100); rare (>1/10 000, <1/1000); very rare (<1/10 000, including individual messages); frequency unknown (frequency cannot be estimated according to the available data).

From the central nervous system:

Rarely: dizziness, headache, general malaise.

From the digestive system:

Common: diarrhea, dyspepsia, nausea, vomiting. Infrequently: colitis.

Frequency unknown: abdominal pain.

Allergic reactions:

Rare: skin rash, pruritus, urticaria.

Frequency unknown: isolated swelling of the face, lips, and eyelids. In exceptional cases, angioedema.

Inform your doctor if you have any adverse reactions or sensations, including those not mentioned in these instructions, as well as changes in laboratory parameters during therapy.

Interaction

There are no data on interactions with other drugs.

You should inform your doctor about all medications you are taking.

How to take, course of use and dosage

Inside, during a meal.

For venous-lymphatic insufficiency – 2 tablets per day (in one or two doses): in the morning, afternoon, and / or evening.

The duration of the course of treatment can be several months (up to 12 months). In case of recurrent symptoms, the course of treatment may be repeated on the doctor’s recommendation.

For acute hemorrhoids – 6 tablets per day: 3 tablets in the morning and 3 tablets in the evening for 4 days, then 4 tablets per day: 2 tablets in the morning and 2 tablets in the evening for the next 3 days.

The recommended dose for chronic hemorrhoids is 2 tablets per day.

Overdose

There are no data on overdose.

Description

Oval biconvex tablets covered with a film-coated orange-pink color, with a risk. The type of tablet on the break is from light yellow to grayish-yellow in color.

Special instructions

Before starting to take Dioridinvel®, it is recommended to consult your doctor.

In case of acute hemorrhoids, the use of Dioridinvel® does not replace the specific treatment of other anal disorders. The duration of treatment should not exceed the time specified in the section “Dosage and use”. If the symptoms do not disappear after the recommended course of therapy, a proctological examination should be performed and the therapy used should be reviewed.

In the presence of venous circulatory disorders, the maximum effect of treatment is provided by combining therapy with a healthy (balanced) lifestyle: it is advisable to avoid long exposure to the sun, long stay on your feet, and it is also recommended to reduce excess body weight. Hiking and, in some cases, wearing special stockings that help improve blood circulation.

Contact your doctor immediately if your condition worsens or does not improve during treatment.

Storage conditions

In a dark place at a temperature not exceeding 25 °C. Keep out of reach of children.

Shelf

life is 3 years. Do not use after the expiration date.

Active ingredient

Hesperidin, Diosmin

Dosage form

Tablets