DRASTOP solution 100mg/ml 2ml ampoules, 10pcs

Composition

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1 ml of the drug contains:

Active ingredient – chondroitin sodium sulfate-100 mg;

excipients-benzyl alcohol-12 mg,

1% sodium hydroxide solution or 0.1 M hydrochloric acid solution – up to pH 6.5 – 6.8,

water for injection – up to 1 ml

Pharmacological action

Pharmacodynamics

It has chondrostimulating, regenerating, anti-inflammatory and analgesic effects. Chondroitin sulfate is involved in the construction of the main substance of cartilage and bone tissue. It has chondroprotective properties, enhances metabolic processes in hyaline and fibrous cartilage, subchondrial bone; inhibits enzymes that cause degradation (destruction) of articular cartilage; stimulates the production of proteoglycans by chondrocytes. It reduces the release of inflammatory mediators and pain factors into the synovial fluid, suppresses the secretion of leukotrienes and prostaglandins. Slows down bone resorption and reduces calcium loss, accelerates the processes of bone recovery. Chondroitin sulfate slows down the progression of osteoarthritis and osteochondrosis.

Promotes the restoration of the articular bag and cartilage surfaces of joints, prevents the collapse of connective tissue, normalizes the production of joint fluid. When using the drug, pain decreases and mobility of the affected joints improves, while the therapeutic effect persists for a long time after the end of the course of therapy. In the treatment of degenerative joint changes accompanied by secondary synovitis, the effect is observed after 2-3 weeks from the start of the course. Having a structural similarity to heparin, it can potentially prevent the formation of fibrin clots in the synovial and subchondrial microcirculation.

Pharmacokinetics

After intravenous use of chondroitin, sodium sulfate is easily absorbed. Within 30 minutes after the injection, it is detected in the blood in significant concentrations. The maximum concentration of chondroitin sodium sulfate in plasma is reached after 1 hour, then gradually decreases over 2 days. Chondroitin sulfate sodium accumulates mainly in the cartilage tissue that forms the joints. The synovial membrane is not an obstacle to the penetration of the drug into the joint cavity. 15 minutes after the intramuscular injection of chondroitin, sodium sulfate is detected in the synovial fluid, then penetrates into the articular cartilage, where its maximum concentration is reached after 48 hours

Indications

Degenerative-dystrophic diseases of the joints and spine:

– osteoarthritis of the peripheral joints;

– intervertebral osteoarthritis and osteochondrosis.

Contraindications

-hypersensitivity to the components of the drug;

– bleeding, tendency to bleeding;

– thrombophlebitis;

– children’s age (efficacy and safety have not been established)

Side effects

Allergic reactions (pruritus, erythema, urticaria, dermatitis), pain and hemorrhages at the injection site, dyspepsia, angioedema.

Interaction

It is possible to increase the effect of indirect anticoagulants, antiplatelet agents, and fibrinolytics, which requires more frequent monitoring of blood clotting parameters when used together.

How to take, course of use and dosage

The drug is prescribed in / m for 1 ml (100 mg of chondroitin sodium sulfate) every other day.

If well tolerated, the dose is increased to 2 ml (200 mg of chondroitin sodium sulfate), starting with the fourth injection. The course of treatment is 25-30 injections.

If necessary, it is possible to conduct repeated courses of treatment after 6 months

Overdose

Overdose is not described and is unlikely.

Special instructions

To achieve a stable clinical effect, at least 25 injections of the drug are required. The effect persists for several months after the end of treatment. Repeated courses of treatment are used to prevent exacerbations. In case of allergic reactions or hemorrhages, treatment should be discontinued.

Influence on the ability to drive vehicles, DRASTOP mechanisms does not affect the ability to drive vehicles and engage in potentially dangerous activities that require increased attention.

Form of production

Clear, slightly yellowish solution

Storage conditions

Store at a temperature not exceeding 25°C. Keep out of reach of children

Shelf

life is 3 years.

Active ingredient

Chondroitin sulfate

Conditions of release from pharmacies

By prescription

Dosage form

solution for injection

Description

For adults as directed by your doctor

Indications

Osteoarthritis, Arthritis, Osteoarthritis, Osteochondrosis