Drotaverin-Teva pills 40mg, 20pcs

Composition

1 tablet contains:

Active ingredient:  

drotaverine hydrochloride 40 mg.

Auxiliary substances:

potato starch 30.71 mg,

lactose monohydrate 57 mg,

crospovidone (Polyplasdon XL-10) 2.923 mg,

povidone (polyvinylpyrrolidone low molecular weight medical) 5.847 mg,

talc 2.05 mg,

magnesium stearate 1.47 mg

Pharmacological action

Drotaverine is a myotropic antispasmodic. In terms of chemical structure and pharmacological properties, it is close to papaverine, but has a stronger and longer-lasting effect.

Reduces the flow of ionized calcium into smooth muscle cells by inhibiting phosphodiesterase and intracellular cAMP accumulation.

It has a pronounced and long-lasting effect on the smooth muscles of internal organs and blood vessels.

Dilates blood vessels, causes a moderate decrease in blood pressure, increases the minute volume of the heart, has some antiarrhythmic effect.

Reduces the tone of brain vessels and increases their blood supply.

It practically does not affect the autonomic nervous system and does not penetrate the central nervous system.

Drotaverine does not have an anticholinergic effect, so unlike cholinolytic antispasmodics, it can be used in patients with glaucoma.

Indications

• spasm of smooth muscles of internal organs (cardiovascular and pilorospazme),
• chronic gastroduodenitis,
• gastric ulcer and duodenal ulcer,
• gallstone disease (hepatic colic),
• chronic cholecystitis,
• postcholecystectomy syndrome,
• hypermotor dyskinesia of the biliary tract,
• spastic dyskinesia of the intestine,
• intestinal colic due to the delay of gases after the operation,
• colitis,
• proctitis,
• tenesmus,
• bloating,
• kidney stones (renal colic),
• pyelitis,
• spasm of cerebral vessels, coronary and peripheral arteries, the need to reduce uterine contractions and relieve cervical spasm during labor,
• smooth muscle spasm during the instrumental interference,
• dysmenorrhea,
• strong contractions.

Drotaverine hydrochloride can also be used as an adjunct in hypertensive crises.

Contraindications

• hypersensitivity to the Active ingredient (drotaverine hydrochloride) or to any of the auxiliary components;
• severe hepatic or renal failure,
• severe heart failure (low cardiac output syndrome),
• AV block II and III degrees,
• cardiogenic shock,
• arterial hypotension,
• children under 12 years of age.

Side effects

• dizziness,
• palpitations,
• low blood pressure,
• feeling hot,
• sweating,
• allergic skin reactions.

Interaction

Increases the effect of other antispasmodics (including M-holinoblokatorov), hypotension caused by tricyclic antidepressants, quinidine, procainamide.

Reduces the spasmogenic activity of morphine, antiparkinsonian properties of levodopa (increased tremor and rigidity are observed).

Reliability of spasm elimination increases phenobarbital.

How to take, course of use and dosage

The drug is intended for intramuscular, subcutaneous, intravenous use.

For adults and children over 12 years of age, the average daily dose is 40-240 mg, divided into 1-3 intramuscular or subcutaneous injections of 2-4 ml of a 2% solution.

In acute hepatic and/or hepatic colic, the drug is administered intravenously slowly in doses of 40-80 mg (2-4 ml of a 2% solution).

In case of peripheral circulatory disorders (obliterating endarteritis, Raynaud’s disease), intra-arterial use is allowed (slowly!).

To shorten the opening phase of the cervix during physiological labor at the beginning of the stretching period, drotaverine hydrochloride is administered intramuscularly at a dose of 40 mg once, with an unsatisfactory effect-repeatedly, once, for 2 hours.

Adults are prescribed inside 40-80 mg (1-2 tablets) 2-3 times a day.

Children under the age of 6 years are prescribed a single dose of 10-20 mg (1/4-1/2 tablets), from 6 to 12 years-20 mg (1/2 tablet) 1-2 times a day.

Overdose

Symptoms: collapse, atrioventricular block, cardiac arrest, paralysis of the respiratory center.

Treatment: symptomatic therapy (no specific antidote).

Special instructions

Intravenous and intra-arterial use is carried out strictly under the supervision of a specialist, preferably in a hospital setting. When the drug is administered intravenously, the patient should be in a supine position due to the risk of collapse.

Influence on the ability to drive vehicles and other mechanisms that require increased concentration of attention

During the treatment period, it is necessary to refrain from driving vehicles and engaging in potentially dangerous activities that require increased concentration of attention and speed of psychomotor reactions.

Form of production

Tablets

Storage conditions

Store in a dry place, protected from light, at a temperature not exceeding 25 °C.

Shelf

life is 3 years.

Active ingredient

Drotaverine

Dosage form

Tablets

Description

Pregnant women as prescribed by a doctor, For adults, Nursing mothers as prescribed by a doctor, Children over 6 years of age, Children as prescribed by a doctor

Indications

Gastroduodenitis, Gastric and Duodenal Ulcers, Urolithiasis, Colitis, Cholelithiasis, Cholecystitis, Enteritis, Threatened Miscarriage, Gastritis