Duzofarm pills 50mg, 90pcs

Composition

1 tablet contains:

Active ingredient:

naphthidrofuryl oxalate – 50 mg.

Auxiliary substances:

lactose monohydrate;

microcrystalline cellulose;

wheat starch;

copovidone;

colloidal silicon dioxide;

magnesium stearate;

talc.

Shell composition:

titanium dioxide; talc; magnesium stearate; macrogol 6000; methacrylic acid and ethyl acrylate copolymer; dye sunny sunset yellow E 110.

Pharmacological action

Dusofarm has a vasodilating effect, as a result of which it improves peripheral and cerebral blood circulation. Causes a decrease in peripheral vascular resistance and increases the minute volume of the heart, without significantly affecting the heart rate and blood pressure.

The vasodilating effect of Dusopharm is the result of its direct myotropic, antagonistic to serotonin 5 HT2 receptors and alpha-adrenoblocking action.

It has a M-holinoblokiruyushchy effect. It has a positive effect on cellular metabolism, improving the utilization of oxygen and glucose. This effect of the drug is due to its ability to increase the level of ATP and inhibit the enzyme succinate dehydrogenase.

Activates glucose utilization through the citric acid cycle and increases the conversion of succinic acid to fumaric acid. As a result, the resistance of cells (including the brain) to hypoxia increases. In addition, Dusopharm reduces the increased blood viscosity.

Indications

Recovery period of cerebral circulatory disorders; peripheral circulatory disorders (intermittent claudication, Raynaud’s disease, trophic ulcers).

Contraindications

Increased individual sensitivity to the drug. Myocardial infarction (acute stage).

Arterial hypotension. Hemorrhagic stroke (acute stage).

Epilepsy, increased convulsive readiness.

Stage II–III chronic heart failure (NYHA Functional Classification of Heart Failure of the New York Heart Association).

Tachyarrhythmias. Age up to 18 years (efficacy and safety have not been established).

With caution:   angle-closure glaucoma; prostatic hyperplasia.

Side effects

When taken orally in doses from 300 to 600 mg, Dusofarm is generally well tolerated.

Possible side effects:  nausea, vomiting, epigastric pain, intestinal colic, diarrhea, decreased appetite, headache, dizziness, sleep disturbance, reversible increase in liver enzyme activity, ulcers of the gastric mucosa, allergic reactions.

Interaction

Increases the antihypertensive effect of antihypertensive drugs.

In this regard, more frequent monitoring of blood pressure is recommended at the beginning of combined treatment with Dusopharm and antihypertensive agents at the same time.

How to take, course of use and dosage

Inside. Tablets are taken whole, with a sufficient amount of liquid (it is recommended to drink water).

For disorders of cerebral circulation:  in a daily dose of 300 mg (2 tablets 3 times a day).

In case of peripheral circulatory disorders:  daily doses – 500-600 mg, divided into 3 doses.

Duzopharm is recommended for long-term oral therapy (up to 6 months).

No dose adjustment is required in patients with renal/hepatic insufficiency.

Overdose

Symptoms:  increased severity of side effects, ventricular arrhythmia, anxiety, decreased blood pressure, bradycardia.

Treatment:  gastric lavage, use of activated charcoal and laxatives, symptomatic treatment.

There is no specific antidote.

Active ingredient

Naftidrofuryl

Conditions of release from pharmacies

By prescription

Dosage form

Tablets

Description

For adults

Indications

Trophic Ulcers, Cerebral Circulation Disorders, Raynaud ‘s disease