Ecofuril, 16pcs

Composition

Composition per capsule:

Active ingredient: nifuroxazide 100.0 mg 200.0 mg

Auxiliary substances: lactitol 300.0 mg 300.0 mg microcrystalline cellulose 102 23.0 mg 58.0 mg potato starch 9.0 mg 18.0 mg magnesium stearate 4.0 mg 6.0 mgsaccharose until the contents of a capsule weighing 460.0 mg 630.0 mg are obtained

Hard gelatin capsules: gelatin up to 100% up to 100% quinoline yellow dye 0.9197% 0.3497%sunset dye 0.0044% 0.0116%titanium dioxide 1.3333% 0.8742%

Pharmacological action

Pharmacotherapy group: antimicrobial agent, nitrofuran

ATX code: A 07 AX 03

Pharmacological properties

Pharmacodynamics Nifuroxazide is an antimicrobial agent derived from nitrofuran. It blocks the activity of dehydrogenases and inhibits respiratory chains, the tricarboxylic acid cycle, and a number of other biochemical processes in the microbial cell. Destroys the membrane of the microbial cell, reduces the production of toxins by microorganisms. Highly active against Campylobacter jejuni, Escherichia coli, Salmonella spp., Shigella spp. ; Clostridium perfringens, Vibrio cholerae, pathogenic Vibrions and Vibrio parahaemolyticus, Staphylococcus spp. The following species are weakly sensitive to nifuroxazide: Citrobacter spp., Enterobacter cloacae, and Proteus indologenes. Resistant to nifuroxazide: Klebsiella spp., Proteus mirabilis, Providencia spp., Pseudomonas spp. He disrupts the balance of intestinal microflora. With bacterial diarrhea, it restores intestinal eubiosis. When infected with enterotropic viruses, they prevent the development of bacterial superinfection.

PharmacokineticsAfter oral use, nifuroxazide is practically not absorbed from the digestive tract, and its antibacterial effect is exerted exclusively in the intestinal lumen. Nifuroxazide is excreted by the intestines: 20% unchanged, and the remaining amount is chemically modified.

Indications

Acute bacterial diarrhea that occurs without deterioration of the general condition, fever, intoxication.

Use during pregnancy and lactation

No teratogenic effect was found in animal studies. However, as a precautionary measure, taking nifuroxazide during pregnancy is not recommended. During the lactation period, it is possible to continue breastfeeding in the case of a short course of treatment with the drug. You should consult your doctor.

Contraindications

Hypersensitivity to nifuroxazide, nitrofuran derivatives or any excipients of the drug.

Children under 3 years of age.

Pregnancy.

Congenital intolerance to fructose, galactose, galactosemia, glucose-galactose malabsorption.

Side effects

Allergic reactions (skin rash, urticaria, angioedema, anaphylactic shock). If any of the side effects listed in the instructions get worse or you notice any other side effects not listed in the instructions, tell your doctor.

Interaction

Concomitant use with drugs that cause the development of disulfiram-like reactions, drugs that inhibit the function of the central nervous system is not recommended. If you are taking other medications (including over-the-counter medications), consult your doctor before using Ecofuril®.

How to take, course of use and dosage

Children from 3 to 6 years: 200 mg (2 capsules of 100 mg or 1 capsule of 200 mg) 3 times a day (the interval between doses is 8 hours). Children from 6 to 18 years: 200 mg (2 capsules of 100 mg or 1 capsule of 200 mg) 3-4 times a day (the interval between doses is 6-8 hours). For adults: 200 mg (2 capsules of 100 mg or 1 capsule of 200 mg) 4 times a day (the interval between doses is 6 hours). The duration of treatment is 5-7 days, but not more than 7 days. If there is no improvement within the first 3 days, then you should consult a doctor. Use the drug only according to the method of use and in the doses indicated in the instructions. If necessary, please consult your doctor before using the medicine.

Overdose

Symptoms of overdose are not known. Treatment is symptomatic.

Description

Solid gelatin capsules No. 00 yellow (for a dosage of 200 mg). The contents of the capsules are a mixture of yellow powder and granules. White splashes are allowed.

Special instructions

When treating diarrhea simultaneously with nifuroxazide therapy, rehydration therapy should be performed. In case of bacterial diarrhea with signs of systemic damage (deterioration of the general condition, fever, symptoms of intoxication or infection), you should consult a doctor to decide on the use of antibacterial drugs of systemic action. If you experience symptoms of hypersensitivity (shortness of breath, swelling of the face, lips, tongue, skin rash, itching), you should immediately stop taking the drug. Alcohol consumption during nifuroxazide therapy is prohibited. The excipients contain sucrose in a dosage of 24 mg for a 100 mg capsule and 48 mg for a 200 mg capsule. Thus, a single dose of sucrose when taking capsules of 100 and 200 mg will be 24 mg and 48 mg, respectively. The daily dose of sucrose when taking capsules of 100 and 200 mg will be 96 mg and 192 mg, respectively.

With caution, liver diseases, alcoholism, traumatic brain injury, brain diseases, lactation, childhood.

Influence on the ability to drive vehicles and mechanismsThe drug does not affect the ability to drive vehicles and mechanisms.

Form of production

100 mg and 200 mg capsules. 10 capsules (100 mg dosage) or 5,7,8 or 10 capsules (200 mg dosage) are placed in a contour cell package made of polyvinyl chloride/polyvinylidene chloride film and aluminum printed varnished foil. 30 capsules (100 mg dosage) or 16,28 or 30 capsules (200 mg dosage) in a polymer jar made of high-density polyethylene with a screw-on lid (upper layer of high-density polyethylene, inner layer of low-density polyethylene).1,2,3,4,5 contour cell packs (for a dosage of 100 mg) or 1,2,3,4,5 contour cell packs of 10 capsules, according to 1,2,3,4,5,6 contour cell packs of 8 capsules,4 contour cell packs of 7 capsules or 6 contour cell packs of 5 capsules (for a dosage of 200 mg) or 1 jar together with the instructions for use is placed in a cardboard pack.

Storage conditions

Store in a place protected from moisture and light at a temperature not exceeding 25 °C. Keep out of reach of children.

Shelf

life is 5 years. Do not use after the expiration date.

Active ingredient

Nifuroxazide

Dosage form

Capsules