Esslial forte 300mg capsules, 30pcs

Composition

1 capsule contains: Active ingredient:  lipoid PPL-400 – 400.0 mg, in terms of polyunsaturated phospholipids from soy lecithin (PPL fraction) – 300.0 mg, with an average content of L-α-phosphatidylcholine 76% – 228.0 mg. Auxiliary substances:  95% ethyl alcohol – 4.0 mg. Solid gelatin capsules No. 0: Capsule body composition:  iron oxide black dye – 0.01%, iron oxide red dye-0.01%, iron oxide yellow dye-0.1714%, titanium dioxide-3%, gelatin – up to 100%; Capsule cap composition:  iron oxide black dye-0.53%, iron oxide red dye-0.93%, iron oxide yellow dye-0.2%, titanium dioxide-0.3333%, gelatin-up to 100%

Pharmacological action

Essential phospholipids are the main elements of the structure of the cell envelope and cellular organelles of the liver. In liver diseases, there is always damage to the membranes of liver cells and their organelles, which leads to violations of the activity of related enzymes and receptor systems, deterioration of the functional activity of liver cells and a decrease in the ability to regenerate. Phospholipids included in the preparation Esslial forte, correspond in their chemical structure to endogenous phospholipids, but surpass endogenous phospholipids in activity due to their higher content of polyunsaturated (essential) fatty acids. The incorporation of these high-energy molecules into damaged areas of the cell membranes of hepatocytes restores the integrity of liver cells and promotes their regeneration. Cis-double bonds of their polyunsaturated fatty acids prevent the parallel arrangement of hydrocarbon chains in the phospholipids of cell membranes, the density of the phospholipid structure of the cell membranes of hepatocytes decreases, which leads to an increase in their fluidity and elasticity, and improves metabolism. The resulting functional blocks increase the activity of enzymes fixed on the membranes and contribute to the normal physiological pathway of the most important metabolic processes. Phospholipids included in the preparation Esslial forte regulate lipoprotein metabolism by transferring neutral fats and cholesterol to oxidation sites, mainly by increasing the ability of high-density lipoproteins to bind to cholesterol. Thus, it has a normalizing effect on the metabolism of lipids and proteins; on the detoxification function of the liver and phospholipid-dependent enzyme systems; which ultimately prevents the formation of connective tissue in the liver and promotes the natural recovery of liver cells. When phospholipids are excreted into the bile, the lithogenic index decreases and the bile stabilizes

Indications

• Chronic hepatitis,

• cirrhosis of the liver,

• fatty liver of various etiologies,

• toxic liver damage,

• alcoholic hepatitis,

• liver function disorders in other somatic diseases.

• Pregnancy toxicosis,

• prevention of recurrent gallstone formation,

• psoriasis (as an adjunct therapy),

• radiation syndrome.

Contraindications

Individual intolerance to phosphatidylcholine or other auxiliary components of the drug. Soy intolerance. Children under 12 years of age (lack of sufficient evidence base).

Side effects

Esslial forte is usually well-tolerated by patients. The following definitions are used to estimate the frequency of side effects: :  very often (>1/10), often (>>1/100 – >><1/10), not often (>1/1000 – <1/10), not often (><1/100), rarely (>1/10000 – <1/100), rarely (><1/1000), very rarely ( From the gastrointestinal tract:  rarely-discomfort in the epigastric region, loosening of the stool, nausea, gastralgia. Allergic reactions: very rare – rash, exanthema, urticaria; unknown frequency-pruritus.

How to take, course of use and dosage

Inside. Capsules should be taken whole, washed down with a sufficient amount of water (approximately 1 cup). For adolescents over 12 years of age and weighing more than 43 kg, as well as for adults, Esslial Forte is recommended to take 2 capsules-3 times a day with meals. As a rule, the duration of application is not limited.

Storage conditions

In a place protected from light at a temperature not exceeding 25 ° C. Keep out of reach of children.

Shelf

life is 3 years. Do not use after the expiration date indicated on the package.

Active ingredient

Phospholipids

Dosage form

Capsules

Description

For adults and children as prescribed by a doctor

Indications

Liver damage, Atherosclerosis, Psoriasis, Cholelithiasis, Poisoning, Obesity, Toxicosis of pregnant women, Cirrhosis of the liver, Hepatitis, Alcoholism, After a course of antibiotic therapy