Estrolet pills 2.5mg, 30pcs

Composition

1 tablet:

Active ingredient:

2.5 mg of letrozole.

Auxiliary substances:

magnesium aluminometasilicate 10 mg,

croscarmellose sodium 3 mg,

colloidal silicon dioxide 3 mg,

magnesium stearate 0.5 mg,

ludipress 81 mg.

Composition of the film shell:

Opadray II yellow 85F32733 (polyvinyl alcohol 35-49%, talc 9.8-25%, macrogol 3350 7.35-35.2%, titanium dioxide and iron oxide yellow 15.15-30%).

Pharmacological action

Antitumor agent.

It is a non-steroidal aromatase inhibitor, an enzyme involved in the synthesis of estrogens in postmenopausal women.

Aromatase promotes the conversion of androgens synthesized in the adrenal glands (primarily androstenedione and testosterone) into estrone and estradiol.

Inhibition of aromatase activity is realized by competitive binding to the cytochrome P450 heme subunit of this enzyme, which leads to a decrease in estrogen biosynthesis in all tissues, including in the tissues of estrogen-dependent tumors.

Indications

Treatment of malignant breast tumors in women during natural or artificially induced menopause after treatment with anti-estrogenic drugs.

Contraindications

Endocrine status characteristic of the premenopausal period; pregnancy, lactation, hypersensitivity to letrozole.

Side effects

Possible:  headache, nausea, peripheral edema, general weakness, hot flashes, thinning hair, skin rash, vomiting, dyspepsia, weight gain, musculoskeletal pain, anorexia, vaginal bleeding, leukorrhea, constipation, dizziness, increased appetite, increased sweating.

Rarely:  shortness of breath, thrombophlebitis, spotting from the vagina.

How to take, course of use and dosage

The dose is 2.5 mg 1 time / day daily.

Treatment continues during the period of disease progression.

Special instructions

In patients with creatinine clearance less than 10 ml/min, the safety of letrozole has not been studied, so if it is necessary to use it in such cases, the ratio between the expected therapeutic effect and the possible risk of treatment should be carefully weighed.

Under the influence of letrozole, the ability to concentrate and the speed of psychomotor reactions may decrease, so it is recommended to avoid driving vehicles and other potentially dangerous activities during treatment.

Form of production

Pills.

Storage conditions

Store in a dry place, protected from light, at a temperature not exceeding 25 °C. Keep out of reach of children.

Shelf

life is 2 years.

Active ingredient

Letrozole

Conditions of release from pharmacies

By prescription

Dosage form

Tablets

Description

For adults as directed by your doctor

Indications

Breast Cancer