Euthyrox 100, pills 100mcg, 100pcs

Composition

>

of 1 tab. contains:

Active ingredients:

levothyroxine sodium – 100 mcg

Auxiliary substances:

corn starch-25.00 mg,

gelatin-5.00 mg,

croscarmellose sodium-3.50 mg,

magnesium stearate-0.50 mg,

lactose monohydrate-65.90 mg

Pharmacological action

Preparation of thyroid hormones. Synthetic levorotatory isomer of thyroxine. After partial conversion to triiodothyronine (in the liver and kidneys) and passing into the cells of the body, it affects the development and growth of tissues, on metabolism. In small doses, it has an anabolic effect on protein and fat metabolism. In medium doses, it stimulates growth and development, increases the need for oxygen in tissues, stimulates the metabolism of proteins, fats and carbohydrates, increases the functional activity of the cardiovascular system and the central nervous system. In large doses, it inhibits the production of thyrotropin-releasing hormone of the hypothalamus and thyroid-stimulating hormone of the pituitary gland.

The therapeutic effect is observed after 7-12 days, during the same time the effect remains after discontinuation of the drug. The clinical effect in hypothyroidism manifests itself in 3-5 days. Diffuse goiter decreases or disappears within 3-6 months.

Pharmacokinetics

Suction and distribution

When taken orally, levothyroxine sodium is absorbed mainly in the upper small intestine. Up to 80% of the drug dose is absorbed. Food intake reduces the absorption of levothyroxine sodium.

Cmax in blood serum is reached approximately 5-6 hours after oral use.

More than 99% of the absorbed drug binds to serum proteins (thyroxine-binding globulin, thyroxine-binding prealbumin and albumin).

Metabolism and elimination

In various tissues, approximately 80% of levothyroxine is monodeodized to form triiodothyronine (T3) and inactive products. Thyroid hormones are primarily metabolized in the liver, kidneys, brain, and muscles. A small amount of the drug undergoes deamination and decarboxylation, as well as conjugation with sulfuric and glucuronic acids (in the liver). Metabolites are excreted by the kidneys and through the intestines.

T1 / 2 is 6-7 days.

Pharmacokinetics in special clinical cases

With thyrotoxicosis, T1 / 2 is shortened to 3-4 days, and with hypothyroidism it is extended to 9-10 days.

Indications

• Hypothyroidism;
• euthyroid goiter;
• as a replacement therapy and for the prevention of recurrent goiter after thyroid resection;
•  thyroid cancer (after surgical treatment);
• diffuse toxic goiter after reaching the euthyroid state with thyrostatics (as a combination therapy or monotherapy);
• as a diagnostic tool for the thyroid suppression test.

Contraindications

• Increased individual sensitivity to the drug.
• Untreated thyrotoxicosis.
• Untreated pituitary insufficiency.
• Untreated adrenal insufficiency.
• Acute myocardial infarction.
• Acute myocardial infarction.
• Acute pancreatitis.

With caution:

For diseases of the cardiovascular system:

• • • Coronary heart disease
    • Atherosclerosis.
    • Angina pectoris.
    • A history of myocardial infarction.
    • Arterial hypertension.
    • Arrhythmias.
    • Diabetes mellitus.
    • Severe long-term hypothyroidism.
    • Malabsorption syndrome (dose adjustment may be required).

Side effects

With proper use of the drug Eutirox under the supervision of a doctor, side effects are not observed.

• With hypersensitivity to the drug, allergic reactions may occur.

The development of side effects may be associated with an overdose of the drug.

Interaction

Levothyroxine sodium enhances the effect of indirect anticoagulants, which may require dose reduction.

The use of tricyclic antidepressants with levothyroxine sodium may increase the effect of antidepressants.

Thyroid hormones may increase the need for insulin and oral hypoglycemic medications. More frequent monitoring of blood glucose concentration is recommended during the start of treatment with levothyroxine sodium, as well as when changing its dosage regimen.

Levothyroxine sodium reduces the effect of cardiac glycosides.

When used simultaneously, colestyramine, colestipol and aluminum hydroxide reduce the plasma concentration of levothyroxine sodium by inhibiting its absorption in the intestine. In this regard, levothyroxine sodium should be used 4-5 hours before taking these drugs.

When used concomitantly with anabolic steroids, asparaginase, tamoxifen, a pharmacokinetic interaction at the level of binding to plasma proteins is possible.

When used simultaneously with phenytoin, dicumarol, salicylates, clofibrate, furosemide in high doses, the content of levothyroxine sodium, which is not bound to plasma proteins, increases.

Taking oestrogen-containing medications increases the content of thyroxine-binding globulin, which may increase the need for lezemyroxine sodium in some patients.

Somatropin, when used concomitantly with levoltroxine sodium, can accelerate the closure of epiphyseal growth zones.

Phenobarbital, carbamazepine, and rifampicin may increase the clearance of levothyroxine nagria and require an increase in the dose.

How to take, course of use and dosage

The daily dose is determined individually depending on the indications.

Eutirox in the daily dose is taken orally in the morning on an empty stomach, at least 30 minutes before meals, with a small amount of liquid (half a glass of water) and without chewing the tablet.

• When performing replacement therapy for hypothyroidism
  • In patients younger than 55 years in the absence of cardiovascular diseases: Eutirox is prescribed in a daily dose of 1.6-1.8 mcg per 1 kg of body weight.
  • In patients over 55 years of age or with cardiovascular diseases: 0.9 mcg per 1 kg of body weight.

If you are significantly obese, the calculation should be made for “ideal weight”.

Initial stage of replacement therapy for hypothyroidism patients without cardiovascular diseases younger than 55 years of age Initial dose:  women – 75-100 mcg / day men-100-150 mcg / day Football players with cardiovascular diseases or older than 55 years

The initial dose is 25 mcg per day Increase by 25 mcg at intervals of 2 months until normalization of TSH in the blood If symptoms from the cardiovascular system appear or worsen, correct the treatment of cardiovascular diseases.

Recommended doses of thyroxine for the treatment of congenital hypothyroidismagainst daily dose of levothyroxine sodium (mcg)Levothyroxine sodium dose per body weight (mcg/kg)0-6 months 25-5010-156-12 months 50-756-81-5 years 75-1005-66-12 years 100-1504-5 over 12 years 100-200

2-3

Indications Recommended doses (Eutirox mcg / day)Treatment of euthyroid goiter 75-200 Prevention of relapse after surgical treatment of goiter spiraeoideae 75-200 In the treatment of thyrotoxicosis 50-100 Suppressive therapy for thyroid cancer 150-300. The thyroid suppression test For 4 weeks before and 3 test 3 test 3 weeks before and 2 weeks before testase 1 week before destiations 75 mg/day 75 mg/day up to 150-200 mg/day 150-200 mg/day

• In patients with severe long-term hypothyroidism

  Treatment should be started with extreme caution, with small doses – from 12.5 mcg / day, the dose is increased to maintenance at longer intervals-by 12.5 mcg/day every 2 weeks, and the TSH concentration in the blood is more often determined.

• For hypothyroidism

  Eutirox is taken, as a rule, throughout life.

• For thyrotoxicosis

  Eutirox is used in combination therapy with antithyroid drugs after reaching the euthyroid state.

In all cases, the duration of treatment with the drug is determined by the doctor. For accurate dosing, it is necessary to use the most appropriate dosage of Eutirox.

Overdose

Symptoms:  with an overdose of the drug, symptoms characteristic of thyrotoxicosis are observed:

• palpitations,
• heart rhythm disturbances
• , heart pain,
• anxiety,
• tremors,
• sleep disturbances,
• increased sweating,
• increased appetite,
• weight loss,
• diarrhea.

Treatment:  depending on the severity of symptoms, the doctor may recommend reducing the daily dose of the drug, taking a break in treatment for several days, and prescribing beta-blockers. After the side effects disappear, treatment should be started with caution with a lower dose.

Special instructions

In hypothyroidism caused by a pituitary gland lesion, it is necessary to find out whether there is simultaneously an insufficiency of the adrenal cortex. In this case, glucocorticoid replacement therapy should be initiated before starting treatment of hypothyroidism with thyroid hormones in order to avoid the development of adrenal insufficiency.

Influence on the ability to drive motor vehicles and manage mechanisms

The drug does not affect activities related to driving vehicles and operating mechanisms.

Form of production

Tablets are white in color, round, flat on both sides, with a chamfer. On both sides of the tablet there is a dividing line, on one side of the tablet there is an engraving “EM+dosage”.

Storage conditions

In a dark place, at a temperature not exceeding 25 °C. Keep out of reach of children.

Shelf

life is 3 years.

Active ingredient

Levothyroxine Sodium

Conditions of release from pharmacies

By prescription

Dosage form

Tablets

Purpose

For adults as prescribed by a doctor, Nursing mothers as prescribed by a doctor, Children as prescribed by a doctor, Pregnant women as prescribed by a doctor

Indications

Hypothyroidism, Cancer