Exoderil, solution for external use 1% 20ml

Composition

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1 ml of the solution contains:

Active ingredient:

naphthifine hydro-chloride-10 mg;

excipients:

propylene glycol-50 mg,

ethanol-400 mg,

purified water-475 mg

Pharmacological action

Pharmacological group:

antifungal agent

ATX Code: D01AE22

Pharmacodynamics

Naftifine is an antifungal agent for external use, belonging to the class of allylamines. The mechanism of action is associated with the inhibition of squalene-2,3 – – epoxidase, which leads to a decrease in the formation of ergosterol, which is part of the cell wall of the fungus. It is active against dermatophytes, such as trichophyton, epidermophyton and microsporum, molds (Aspergillus spp. ), yeast fungi (Candida spp., Pityrosporum) and other fungi (for example, Sporothrix schenckii).

Naftifine acts as a fungicide against dermatophytes and aspergillus. In relation to yeast fungi, the drug exhibits fungicidal or fungistatic activity, depending on the strain of the microorganism. It has antibacterial activity against gram-positive and gram-negative microorganisms that can cause secondary bacterial infections. It has an anti-inflammatory effect, which contributes to the rapid disappearance of inflammatory symptoms, especially itching.

Pharmacokinetics

Naftifine quickly penetrates the skin, creating stable antifungal concentrations in its various layers, which makes it possible to use it once a day.

Indications

-fungal infections of the skin and skin folds (tinea corporis, tinea inguinalis), including interdigital mycoses (tinea manum, tinea pedum);

– fungal infections of the nails (onychomycosis);

– candidiasis of the skin;

– pityriasis;

– dermatomycosis (with or without concomitant itching).

Exoderyl® is effective in the treatment of mycoses affecting areas of the skin with hyperkeratosis, as well as in areas of hair growth.

Contraindications

Hypersensitivity to naphthifine or propylene glycol; pregnancy and lactation (safety and efficacy of the drug have not been determined).

Application of the drug to the wound surface is contraindicated.

With caution

Children’s age (limited clinical experience).

Side effects

In some cases, local reactions may occur: dry skin, hyperemia of the skin and burning.

Side effects are reversible and do not require discontinuation of treatment.

Interaction

There was no drug interaction of Exoderil with other drugs.

How to take, course of use and dosage

Externally. Exoderyl® is applied once a day to the affected skin surface and adjacent areas (approximately 1 cm of healthy skin along the edges of the affected area) after thorough cleaning and drying.

The duration of therapy for dermatomycosis is 2-4 weeks (if necessary-up to 8 weeks), for candidiasis-4 weeks. If the nails are affected, Exoderyl® is applied 2 times a day to the affected nail.

Before the first application of the drug, the affected part of the nail is removed as much as possible with scissors or a nail file. The duration of therapy for onychomycosis is up to 6 months.

To prevent relapse, treatment should be continued for at least 2 weeks after the clinical symptoms disappear.

Overdose

No overdose cases have been reported.

Special instructions

Precautions for use:

Exoderil® is not intended for use in ophthalmology. Do not allow the drug to get into the eyes.

Influence on the ability to drive vehicles and other mechanisms:

Exoderyl® does not adversely affect the ability to drive vehicles and perform other activities that require concentration of attention and speed of psychomotor reactions.

Form of production

Clear, colorless or slightly yellow solution with an ethanol smell.

Storage conditions

Keep out of reach of children at a temperature not exceeding 30°C.

Shelf

life is 5 years.

Active ingredient

Naftifine

Dosage form

solution for external use

Description

For children as prescribed by a doctor, For adults

Indications

Skin Fungus, Nail Fungus Fungus and