Famotidine, pills 20mg, 20pcs

Composition

1 film-coated tablet 20 mg, contains the Active ingredient famotidine 20 mg.

Auxiliary substances:  

Corn starch — 16.0 mg,

microcrystalline cellulose-78.35 mg,

Silicon dioxide — 1.4 mg,

Talcum powder — 5,625 mg,

Magnesium stearate — 1,125 mg,

Croscarmellose sodium — 2.5 mg.

Shell:  

Hypromellose — 2.5 mg,

Titanium dioxide — 1.53 mg,

Lactose monohydrate — 1,313 mg,

Macrogol-4000-0.5 mg,

Triacetin — 0.375 mg,

Iron oxide yellow dye [E 172] — 0.021 mg,

Iron oxide red dye [E 172] – 0.006 mg,

Iron oxide black dye [E 172] — 0.005 mg

Pharmacological action

Famotidine – antiulcer.

Blocks histamine_H2-receptors, suppresses the production of hydrochloric acid.

Indications

• Peptic ulcer of the stomach and duodenum 12, prevention of relapses;
• Erosive gastroduodenitis;
• Functional dyspepsia associated with increased secretory function;
• Symptomatic and stressful gastrointestinal ulcers;
• Reflux esophagitis;
• prevention of relapses associated with prolonged use of nonsteroidal anti-inflammatory drugs;
• Zollinger-Ellison syndrome;
• Systemic mastocytosis;
• Polyendocrine adenomatosis;
• Prevention of recurrent bleeding in the postoperative period;
• Prevention of gastric juice aspiration in patients undergoing surgery under general anesthesia (Mendelssohn syndrome);
• Prevention of aspiration pneumonitis;
• Dyspepsia with epigastric or retrosternal pain that occurs at night or associated with food intake.

Use during pregnancy and lactation

Penetrates through the placenta. Use during pregnancy is possible only if the benefit to the mother exceeds the risk to the fetus.

Penetrates into breast milk; if necessary, use during lactation should either stop using the drug, or breast-feeding.

Contraindications

• pregnancy;
• lactation;
• children under 3 years of age with a body weight of less than 20 kg (for this dosage form);
• hypersensitivity to famotidine and other histamine_H2-receptor blockers.

With caution:  hepatic and / or renal insufficiency, cirrhosis of the liver with portosystemic encephalopathy (in the anamnesis), immunodeficiency, childhood.

Side effects

From the side of the digestive system possible:  dry mouth, nausea, vomiting, abdominal pain, rarely-loss of appetite, increased activity of “liver” transaminases, constipation, diarrhea, jaundice, hepatocellular, cholestatic or mixed hepatitis, in some cases may develop acute pancreatitis.

Nervous system disorders:  headache, dizziness; asthenia, drowsiness, insomnia, restlessness, nervousness, depression, psychosis; cases of hallucinations, confusion, blurred vision, hyperthermia are described.

From the cardiovascular system:  very rarely-low blood pressure, bradycardia, atrioventricular block, arrhythmia, vasculitis.

Allergic reactions:  skin rash, pruritus, bronchospasm, angioedema, erythema multiforme, exfoliative dermatitis, Stevens-Johnson syndrome, toxic epidermal necrolysis, anaphylactic shock.

From the side of hematopoietic organs:  rarely-neutropenia, leukopenia, thrombocytopenia, hemolytic anemia; in rare cases-agranulocytosis, pancytopenia, hypoplasia, bone marrow aplasia.

From the side of the reproductive system:  with prolonged use of large doses-hyperprolactinemia, gynecomastia, amenorrhea, decreased libido, impotence.

Other services:  rarely – fever, arthralgia, myalgia, ringing in the ears, dry skin, alopecia.

Interaction

Antacids interfere with absorption (a break between taking antacids and famotidine for at least 1-2 hours is recommended).

How to take, course of use and dosage

Inside, without chewing, with a sufficient amount of water.

Adults:

When peptic ulcer of the stomach and duodenum 12 in the acute phase, symptomatic ulcers, erosive gastroduodenitis is usually prescribed 20 mg 2 times a day or 40 mg 1 time a day at night.

If necessary, the daily dose can be increased to 80-160 mg. The course of treatment is 4-8 weeks.

For dyspepsia associated with increased secretory function of the stomach,20 mg is prescribed 1-2 times a day.

In order to prevent relapses of peptic ulcer disease,20 mg is prescribed 1 time a day before bedtime.

For reflux esophagitis,20-40 mg twice a day for 6-12 weeks.

In Zollinger-Ellison syndrome, the dose of the drug and the duration of the course of treatment are set individually.

The initial dose is usually 20 mg every 6 hours and can be increased to 160 mg every 6 hours.

To prevent gastric juice aspiration under general anesthesia,40 mg is prescribed in the evening and / or in the morning before surgery.

Famotidine tablets should be swallowed without chewing, washed down with a sufficient amount of water.

In patients with renal insufficiency, if the creatinine clearance is less than 30 ml / min or the serum creatinine content is more than 3 mg / 100 ml, the daily dose of the drug should be reduced to 20 mg.

Overdose

Symptoms:  

vomiting, motor agitation, tremor, low blood pressure, tachycardia, collapse.

Treatment:  

gastric lavage, symptomatic and supportive care, hemodialysis.

Appointment

of gastric Glands secretion lowering agent-H2-histamine receptor blocker

Description

Film-coated tablets 20 mg: round, biconvex film-coated tablets, pale pink with a grayish tinge of color, white at the break.

Complete set

Film-coated tablets 20 mg. 10 film-coated tablets in a PVC/AL blister. 2 or 3 blisters with instructions for use in a cardboard pack.

Special instructions

Before starting treatment, it is necessary to exclude the possibility of a malignant disease of the esophagus, stomach or duodenum, since Famotidine can mask the symptoms.

Symptoms of duodenal ulcer disease may disappear within 1-2 weeks, and therapy should be continued until the scarring is confirmed by endoscopic or X-ray examination.

Cancel Famotidine gradually due to the risk of developing a “rebound” syndrome with abrupt cancellation.

With prolonged treatment in weakened patients, as well as under stress, bacterial lesions of the stomach are possible with the subsequent spread of infection.

Famotidine (an H2-histamine receptor blocker) should be taken 2 hours after taking itraconazole or ketoconazole to avoid a significant decrease in their absorption.

It counteracts the effect of pentagastrin and histamine on the acid-forming function of the stomach, so it is not recommended to use Famotidine during the 24 hours preceding the test.

Famotidine suppresses the skin reaction to histamine, thus leading to false negative results (before conducting diagnostic skin tests to detect an immediate allergic skin reaction, it is recommended to stop using Famotidine).

During treatment, the use of food, beverages, etc. should be avoided. Drugs that can cause irritation of the gastric mucosa.

The effectiveness of Famotidine in inhibiting nocturnal acid secretion in the stomach may be reduced as a result of smoking.

Patients with burns may need to increase the dose of the drug due to increased clearance.

If a dose is missed, it should be taken as soon as possible; do not take it if it is time to take the next dose; do not double the dose. If there is no improvement, you should consult a doctor.

Form of production

Tablets

Storage conditions

In a place protected from light and moisture, at a temperature of 15-25 °C

Shelf

life is 3 years. Do not use after the expiration date indicated on the package.

Active ingredient

Famotidine

Conditions of release from pharmacies

By prescription

Dosage form

Tablets

Description

For adults by doctor’s prescription, Children by doctor’s prescription, Children over 16 years of age

Indications

Gastroduodenitis, Reflux Esophagitis, Gastric and duodenal ulcers, Gastritis, Heartburn