Febrofid, gel 2.5%, 50g

Composition

Active ingredient:

Ketoprofen lysine salt,2.5 g/100.0 g gel

Auxiliary substances:

macrogol

200-5 g, methyl parahydroxybenzoate-0.15 g,

propyl parahydroxybenzoate-0.05 g,

carbomer-1.5 g,

trollamine-2.5 g,

purified water – up to 100 g.

Pharmacological action

Ketoprofen belongs to the group of NSAIDs that have anti-inflammatory, anti-exudative and analgesic effects. In the form of a gel, it provides local treatment of lesions of joints, tendons, ligaments, muscles, skin, veins, lymph vessels and lymph nodes. With joint syndrome, it causes a reduction in joint pain at rest and during movement, a decrease in morning stiffness and swelling of the joints.

Pharmacokinetics

Penetrates well through the skin. The bioavailability of the gel is about 5%. The absorbed portion of ketoprofen binds to plasma proteins by approximately 99%. It is metabolized in the liver. About 80% of the dose taken is excreted in the urine in the form of metabolites, less than 10% – in unchanged form.

It does not accumulate in the body.

Indications

As a drug for external use in symptomatic treatment:

• back pain;
• neuralgia;
• myalgia;
• inflammatory and degenerative diseases of the musculoskeletal system ( including arthritis, bursitis, synovitis, tendonitis, lumbago);
• uncomplicated injuries (including sports, sprains, sprain or rupture of ligaments and tendons, bruises, post-traumatic pain);
• in combination therapy for inflammatory diseases of the veins (phlebitis, periflebit), lymphatic vessels, lymph nodes (lymphangitis, lymphadenitis surface).

Use during pregnancy and lactation

In the first and second trimesters of pregnancy, the drug can only be used if necessary.

In the third trimester of pregnancy, the use of the drug is contraindicated.

It is not recommended to use during breastfeeding.

Contraindications

• wet dermatoses, eczema;
• infected abrasions, wounds, burns;
• third trimester of pregnancy;
• lactation (breastfeeding);
• hypersensitivity to ketoprofen and/or other components of the drug;
• hypersensitivity to other NSAIDs (ketoprofen may cause bronchospasm in persons sensitive to acetylsalicylic acid and other NSAIDs).

Side effects

Possible: allergic reactions, hyperemia of the skin, photosensitization, skin exanthema, purpura.

Interaction

With frequent and prolonged use, symptoms of interaction with other drugs may appear (the same as with systemic use).

When taken together with other NSAIDs, corticosteroids, ethanol, corticotropin, ulceration and the development of gastrointestinal bleeding may occur.

Concomitant use with oral anticoagulants, heparin, thrombolytics, antiplatelet agents, cefoperazone, cefamandol increases the risk of bleeding.

Ketoprofen reduces the effect of antihypertensive drugs and diuretics (inhibition of prostaglandin synthesis).

Increases the hypoglycemic effect of insulin and oral hypoglycemic drugs (dose adjustment is necessary). Co-use with sodium valproate causes a violation of platelet aggregation. Increases the concentration of verapamil and nifedipine in the blood plasma.

How to take, course of use and dosage

The drug is intended for external use.

Apply a small amount (3-5 cm long strip) of gel 2-3 times/day to the appropriate area of the skin and rub it lightly.

There is no need to apply a dry dressing, because the gel is well absorbed through the skin, has no smell, does not contain coloring substances, does not leave greasy spots, does not stain clothes.

Overdose

Due to the low systemic absorption, an overdose of Febrofid is unlikely.

Special instructions

Do not allow the gel to get on the mucous membranes and in the eyes.

The drug should not be applied to damaged areas of the skin.

Caution should be exercised with prolonged use in patients with severe hepatic or renal insufficiency.

In case of rash, it is necessary to stop using the drug and conduct appropriate therapy.

Form of production

Gel for external use.

Storage conditions

In a dark place, at a temperature of 15-25 °C

Shelf life

2 years

Active ingredient

Ketoprofen

Dosage form

gel for external use

Description

For adults, Pregnant women in the first and second trimester as prescribed by a doctor, Children as prescribed by a doctor

Indications

Osteochondrosis, Sciatica, Myositis, Bursitis, Swelling after injuries and operations, Tendon inflammation, Sciatica, Lumbago, Osteoarthritis, Bruises, Gout, Osteoarthritis and Arthritis, Dislocations and Sprains, Rheumatoid arthritis