Flemoxin Solutab, pills 500mg, 20pcs

Composition

Active ingredient:

amoxicillin (in trihydrate form) 500 mg.

Auxiliary substances:

dispersible

cellulose, microcrystalline cellulose,

crospovidone,

vanillin,

flavorings (tangerine, lemon),

saccharin,

magnesium stearate

Pharmacological action

Flemoxin Solutab-bactericidal, antibacterial.

Pharmacodynamics

It is active against gram-positive and gram-negative microorganisms such as:  Streptococcus pyogenes, Streptococcus pneumonia, Clostridium tetani, C. welchii, Neisseria gonorrhoeae, Neisseria meningitidis, Staphylococcus aureus (that do not produce beta-lactamases), Bacillus anthracis, Listeria monocytogenes, Helicobacter pylori.

It is less active against Enterococcus faecalis, Escherichia coli, Proteus mirabilis, Salmonella typhi, Shigella sonnei, Vibrio cholerae. It is not active against microorganisms producing beta-lactamases, Pseudomonas spp., indole-positive Proteus spp., Serratia spp., Enterobacter spp.

Pharmacokinetics

Suction

After oral use, it is absorbed quickly and almost completely (about 93%), acid-resistant. After oral use at a dose of 500 mg, the Cmax of the Active ingredient in plasma is 5 mcg / ml and is noted in blood plasma after 2 hours. When the dose of the drug is increased or decreased by 2 times, Cmax in blood plasma also changes by 2 times. Food intake practically does not affect the absorption of the drug.

Distribution

Binding to plasma proteins is about 20%. Amoxicillin penetrates well into the mucous membranes, bone tissue, intraocular fluid and sputum in therapeutically effective concentrations. The concentration of amoxicillin in bile exceeds its concentration in blood plasma by 2-4 times. In the amniotic fluid and umbilical vessels, the concentration of amoxicillin is 25-30% of its level in the blood plasma of a pregnant woman.

Poorly penetrates the BBB, but with inflammation of the meninges, the concentration in the cerebrospinal fluid is about 20% of the concentration in blood plasma.

Metabolism

Partially metabolized, most of its metabolites are inactive against microorganisms.

Deduction

It is eliminated mainly by the kidneys, about 80% by tubular excretion,20% by glomerular filtration. In the absence of impaired renal function, T1 / 2 is 1-1.5 hours. In preterm infants, newborns and children under 6 months-3-4 hours

. Pharmacokinetics in special clinical cases.

T1 / 2 of amoxicillin does not change with impaired liver function.

With impaired renal function (Cl creatinine ≤15 ml / min), T1 / 2 of amoxicillin may increase and reaches 8.5 hours in anuria.

Indications

Pneumonia, bronchitis, urinary tract infections, sinusitis, otitis media.

Contraindications

Hypersensitivity (including to other antibiotics-penicillins, cephalosporins, carbapenems), bronchial asthma, pollinosis, liver failure.

Interaction

Probenecid, phenylbutazone, oxifenbutazone, and to a lesser extent acetylsalicylic acid and sulfinpyrazone inhibit the tubular secretion of penicillin-type drugs, which leads to an increase in T1/2 and an increase in the concentration of amoxicillin in blood plasma. Bactericidal antibiotics (including aminoglycosides, cephalosporins, vancomycin, rifampicin) show synergy when taken simultaneously.

Antagonism is possible when taken with certain bacteriostatic drugs (for example, chloramphenicol, sulfonamides). Concomitant use of amoxicillin with estrogen-containing oral contraceptives may reduce the effectiveness of the latter and increase the risk of acyclic bleeding.

Concomitant use of amoxicillin with allopurinol does not increase the frequency of skin reactions, in contrast to the combination of allopurinol with ampicillin.

How to take, course of use and dosage

The drug is taken orally. The drug is prescribed regardless of food intake. The tablet can be swallowed whole, divided into parts or chewed with a glass of water, and can also be diluted in water to form a syrup (in 20 ml) or suspension (in 100 ml), which has a pleasant fruit taste. The dosage regimen is set individually, taking into account the severity of the disease, the sensitivity of the pathogen to the drug, and the patient’s age. In the case of infectious-inflammatory disease of mild to moderate severity, it is recommended the use of the drug according to the following scheme: adults and children over 10 years: 500-750 mg 2 times/day or 375-500 mg 3 times/day; children aged 3 to 10 years old it is administered 375 mg 2 times/day or 250 mg 3 times/day; children aged 1 to 3 years: 250 mg 2 times/day or 125 mg 3 times/day.

The daily dose of the drug for children (including children under 1 year) is 30-60 mg / kg / day, divided into 2-3 doses.

For hard-to-reach foci of infection (for example, acute otitis media), a triple dose is recommended.

For chronic diseases, recurrent infections, severe infections, adults are prescribed 0.75-1 g 3 times/day; children-60 mg / kg/day, divided into 3 doses.

In acute uncomplicated gonorrhea,3 g of the drug is prescribed in 1 dose in combination with 1 g of probenecid.

In patients with impaired renal function with creatinine clearance<10 ml / min, the dose of the drug is reduced by 15-50%.

In the case of mild to moderate infections, the drug is taken for 5-7 days. However, for Streptococcus pyogenes infections, the duration of treatment should be at least 10 days.

In the treatment of chronic diseases, severe infections, the duration of taking the drug should be determined by the clinical picture of the disease. The drug should be continued for 48 hours after the disappearance of symptoms of the disease.

Overdose

Overdose of Flemoxin Solutab may have the following symptoms: vomiting, nausea, diarrhea.

Due to vomiting and diarrhea, dehydration of the body and a violation of the water-electrolyte balance can occur.

In case of overdose, enterosorbents, salt group laxatives, and hydration measures are prescribed.

Special instructions

Prescribe the drug to patients with infectious mononucleosis and lymphocytic leukemia with caution, since there is a high probability of the appearance of non-allergic exanthema.

The presence of a history of erythroderma is not a contraindication for the appointment of Flemoxin Solutab. Possible cross-resistance and cross-hypersensitivity with penicillin-type drugs, cephalosporins. As with other penicillin-type drugs, superinfections may develop.

The appearance of severe diarrhea, characteristic of pseudomembranous colitis, is an indication for the withdrawal of prep

Form of production

Tablets

Storage conditions

At a temperature not exceeding 25 °C

Shelf life

5 years

Active ingredient

Amoxicillin

Conditions of release from pharmacies

By prescription

Dosage form

Tablets

Description

Children as prescribed by a doctor, Adults as prescribed by a doctor, Pregnant women as prescribed by a doctor, Nursing mothers as prescribed by a doctor

Indications

Urinary Tract Infections, Biliary Tract Infections, Bronchitis, Skin Infections, Tonsillitis, Intestinal Infections, Respiratory Tract Infections, Otitis media, Pharyngitis, Sore Throat, Gastrointestinal Infections Caused by Helicobacter Pylori