Flucinar N, ointment, 15g

Composition

Active ingredients:

fluocinolone acetonide 0.25 mg,

neomycin sulfate 5 mg,

excipients:

propylene glycol;

liquid paraffin;

lanolin anhydrous;

white vaseline

Pharmacological action

Flucinar N is a combined drug with anti-inflammatory and antibacterial effects.

Fluocinolone acetonide is a synthetic corticosteroid for external use. It is 40 times more active than hydrocortisone. It has anti-inflammatory, antipruritic, antiexudative, anti-allergic and vasoconstrictor effects. The mechanism of anti-inflammatory action is not fully understood. It is believed that fluocinolone acetonide reduces the manifestations of the inflammatory process by inhibiting the synthesis of prostaglandins and leukotrienes by inhibiting the activity of phospholipase a2 and reducing the release of arachidonic acid from the phospholipids of the cell wall. As a result, hyperemia and exudation in the lesion are reduced. Stabilizes cellular and subcellular (including lysosomal) membranes. Reduces the release of proteolytic enzymes from lysosomes. Reduces membrane permeability, mitotic activity, and release of inflammatory mediators.

When exposed to the skin, the marginal accumulation of neutrophils is prevented, which leads to a decrease in inflammatory exudate and lymphokine production, inhibition of macrophage migration, and a decrease in infiltration and granulation processes. Inhibits the phase of alteration and limits the focus of inflammation, reduces the migration of white blood cells and lymphocytes to the focus of inflammation. Inhibits the synthesis or release of cytokines (interleukins and interferon) from lymphocytes and macrophages. Reduces the severity of the early immune response.

Neomycin is an antibiotic of the aminoglycoside group. In low concentrations, it has a bacteriostatic effect, in high concentrations – bactericidal. The mechanism of action is associated with a direct effect on ribosomes and inhibition of bacterial cell protein synthesis.

Flucinar N active against gram-positive microogranisms: Staphylococcus spp., Streptococcus spp. Corynebacterium diphtheriae, Listeria monocytogenes, Bacillus antracis, Clostridium spp., Actinomyces spp. Neisseria meningitidis; microorganismos gram-negative: Escherichia coli, Shigella spp., Salmonella spp. Proteus spp. Enterobacter aerogenes, Vibrio cholerae, Haemophilus influenzae, Klebsiella pneumoniae, Bordetella pertussis, Pasteurella multocida, Borrelia spp., Treponema pallidum, Fusobacterium spp., Leptospira spp.

It has activity against acid-resistant Mycobacterium tuberculosis.

Resistance of microorganisms to neomycin develops slowly and to a small extent.

As a result of the combined action of fluocinolone acetonide and neomycin, the drug suppresses the development of inflammatory and allergic skin reactions complicated by bacterial infection.

Indications

Allergodermatoses complicated by bacterial infection caused by neomycin-sensitive flora:

• allergic (including contact, professional, and solar) dermatitis;
• eczema (including contact, constitutional, nummular, seborrheic);
• urticaria;
• psoriasis (including scalp);
• erythema multiforme;
• erythroderma;
• atopic dermatitis;
• pruritus;
• dermatitis, is not amenable to treatment with other corticosteroids (including lichen planus, lupus erythematosus /cutaneous manifestations/);
• secondary infection with insect bites.

Bacterial skin infections caused by neomycin-sensitive flora, complicated by the development of allergic reactions:

• impetigo;
• infected diaper rash.

First-degree burns.

Contraindications

• Hypersensitivity;
• acne;
• bacterial (including tuberculosis),
• fungal, viral and tumor skin diseases.

Side effects

• Atrophy of the skin and subcutaneous fat,
• lupus-like syndrome with a mild course,
• the appearance or exacerbation of symptoms of lichen planus,
• epithelialization disorders,
• slowing healing of wounds and ulcerative lesions,
• petechiae,
• steroid purpura,
• striae,
• hirsutism,
• baldness in women,
• maculopapular skin rash.

How to take, course of use and dosage

Externally, a small amount of Fluzinar H ointment is applied to the affected skin areas 2-3 times a day, no more than 2 g / day, after the acute inflammatory process subsides — 1-2 times a day. If necessary, apply a breathable bandage. With excessive peeling of the stratum corneum of the epidermis (lichenization) or excessive keratinization of altered areas, it is possible to use an occlusive dressing, which is changed every 24-48 hours. The course of continuous treatment is not more than 2 weeks.

Children over 2 years of age should be treated with caution, only once a day on small areas of the skin.

Overdose

Symptoms:  if the dosage regimen is not followed (prolonged use of the drug on large areas of the skin), systemic side effects of the drug may develop, such as increased blood pressure, edema, and immunosuppressive effects.

Treatment:  discontinuation of the drug.

Special instructions

With prolonged use and when applied to large areas of the skin (under occlusive dressings), patients should be subjected to systematic examinations (systemic side effects may occur).

Form of production

Ointment

Storage conditions

In a dark place, at a temperature not exceeding 25°C.

Shelf

life is 3 years.

Active ingredient

Neomycin, Fluocinolone Acetonide

Conditions of release from pharmacies

By prescription

Dosage form

ointment

Description

For adults as prescribed by a doctor, Children over 2 years of age

Indications

Urticaria, Neurodermatitis, Dermatosis, Allergies, Burns, Eczema, Insect Bites, Dermatitis, Psoriasis