Fucithalmic, eye drops 1%, 5g

Composition

1 g of the drug contains: Active ingredient: Micronized fusidic acid (in terms of anhydrous acid) – 10.00 mg (equivalent to 10.17 mg of fusidic acid hemihydrate). Auxiliary substances: Benzalkonium chloride 0.11 mg, disodium edetate 0.50 mg, mannitol 50.00 mg, carbomer 5.00 mg, sodium hydroxide q. s., water for injection up to 1.0 g

Pharmacological action

Antimicrobial drug, an antibiotic of polycyclic structure, belongs to the fusidine group. The mechanism of action is associated with a violation of protein synthesis in the bacterial cell.

By blocking the elongation of factor G, it prevents its binding to ribosomes and guanosine triphosphate, which interrupts the release of energy necessary for protein synthesis and leads to the death of the bacterial cell.

It is active against microorganisms that most often cause eye infections: Staphylococcus aureus, Streptococcus pneumoniae, Haemophilus influenzae.

Enterobacteriaciae and Pseudomonas spp. resistant to the action of fusidic acid.

There are no reports of cross-resistance to fusidic acid.

Pharmacokinetics

Suction and distribution

Dosage form of the drug (viscous eye drops) provides long-term contact with the conjunctiva and sufficient concentration of fusidic acid in the tear fluid under the condition of application 2 times/day.

After 1,3,6 and 12 h after a single application of Fucithalmic average concentration of fusidic acid in the tear fluid is 15.7; 15.2; 10.5 and 5.6 µg/ml, respectively. In the intraocular fluid, the concentration of fusidic acid equal to 0.3 mcg / ml (after a single application) and 0.8 mcg/ml (after repeated application) is reached within 1 hour after application and maintained for at least 12 hours, while fusidic acid in the blood serum is not detected.

Deduction

It is mainly excreted in the bile. Urinary excretion is less than 1% of the dose.

Indications

Bacterial eye infections: conjunctivitis; blepharitis; keratitis; dacryocystitis.

Use during pregnancy and lactation

It can be used as prescribed by the attending physician, if the expected therapeutic effect exceeds the potential risk of side effects.

Use in children

It can be used according to indications according to the dosage regimen.

Contraindications

Individual hypersensitivity to the components of the drug Fucithalmic. The preservative (benzalkonium chloride) is a potential allergen.

Side effects

Rarely-allergic reactions in the form of edema of the follicles of the transitional fold of the conjunctiva and urticaria.

Possible — itching, burning, conjunctival hyperemia, soreness, lacrimation, swelling of the eyelids, exacerbation of conjunctivitis.

Therapy with Fucithalmic should be discontinued if signs of hypersensitivity to the drug appear.

Interaction

There are no data on drug interactions.

How to take, course of use and dosage

Conjunctival. 1 drop into the conjunctival cavity of the affected eye 2 times a day for 7 days.

If there is no positive dynamics within 7 days of using the drug, the therapy should be reviewed using other drugs.

Overdose

There are no data on overdose of the drug.

Special instructions

Long-term use of an antimicrobial drug can lead to the development of superinfection caused by microorganisms resistant to this drug, including fungi.

The tube must be closed after each use. Do not touch the tip of the tube to the eye.

It is not recommended to wear contact lenses while using the drug Futsitalmik. Fusidic acid microcrystals can cause scratches on the lenses or cornea.

Influence on the ability to drive motor vehicles and manage mechanisms

If blurred vision occurs after instillation, it is necessary to refrain from driving vehicles and engaging in potentially dangerous activities that require increased concentration of attention and speed of psychomotor reactions until vision is restored.

Form of production

Eye drops

Storage conditions

At a temperature not exceeding 25 °C.

Shelf

life is 3 years, after opening-1 month.

Active ingredient

Fusidic acid

Conditions of release from pharmacies

By prescription

Dosage form

eye drops

Description

For pregnant women as prescribed by a doctor, for Nursing mothers as prescribed by a doctor, For adults as prescribed by a doctor

Indications

Conjunctivitis, Eye Infections, Blepharitis, Inflammatory eye diseases