Glencet, pills 5mg, 7pcs

Composition

Active ingredient:  

levocetirizine dihydrochloride 5 mg

Auxiliary substances:  

Lactose monohydrate (Lactose 100)

microcrystalline cellulose (Avicel PH 112)

colloidal silicon dioxide (Aerosil 200)

opadray white magnesium stearate

Pharmacological action

of Glencet-enantiomer of cetirizine:

– competitive antagonist of histamine;

– blocks H1 -histamine receptors, the affinity of which is 2 times higher than that of cetirizine;

– influences histaminosis stage of allergic reactions;

reduces the migration of eosinophils, vascular permeability;

– limits the release of inflammatory mediators;

– prevents the development and facilitates the course of allergic reactions;

– has antiexudative, antipruritic effect; 

– practically does not have anticholinergic and antiserotonin effects;

– in therapeutic doses, the sedative effect is very weakly expressed.

The action begins 12 minutes after taking a single dose in 50% of patients, after 1 hour – in 95% and continues for 24 hours.

Indications

Symptomatic treatment of year-round and seasonal allergic rhinitis and allergic conjunctivitis (sneezing, rhinorrhea, lacrimation, conjunctival hyperemia), pollinosis, urticaria (including chronic idiopathic, Quincke’s edema) and other allergic dermatoses accompanied by itching and rashes.

Use during pregnancy and lactation

The drug is contraindicated during pregnancy and lactation.

Contraindications

Hypersensitivity, including to piperazine derivatives,

severe chronic renal failure (Cl creatinine

Side effects

Headache, drowsiness, dry mouth, fatigue; rarely-migraine, dizziness, dyspeptic phenomena, allergic reactions (angioedema, rash, urticaria, itching).

Interaction

Theophylline (400 mg/day) reduces the total clearance of levocetirizine by 16%, while the kinetics of theophylline does not change.

Concomitant use with macrolides or ketoconazole did not cause significant ECG changes.

It can enhance the effect of drugs that depress the central nervous system and ethanol.

How to take, course of use and dosage

Inside, during a meal or on an empty stomach, with a small amount of water, without chewing.

The recommended dose for adults and children over 6 years of age, elderly patients (subject to normal renal function) – 5 mg (1 tablet) 1 time a day.

In patients with chronic renal failure, the dose is reduced 2-fold (1 tablet every other day) with creatinine clearance from 30 to 49 ml / min and 3-fold (1 tablet every 3 days) with creatinine clearance from 10 to 29 ml / min.

Patients with hepatic insufficiency do not need to adjust the dosage regimen.

The course of treatment for chronic diseases is up to 18 months.

Overdose

Symptoms:  drowsiness, in children – anxiety, irritability.

Treatment:  gastric lavage, activated charcoal, symptomatic therapy.

There is no specific antidote.

Hemodialysis is ineffective.

Special instructions

Caution is required when using alcohol concomitantly (see Interactions with other medications).

Influence on the ability to drive motor vehicles and manage mechanisms

Objective evaluation showed no significant effect of the drug on the ability to drive vehicles and manage mechanisms when taken at the recommended dose.

However, during the period of taking the drug, it is advisable to refrain from engaging in potentially dangerous activities that require increased concentration of attention and speed of psychomotor reactions.

Composition

Tablet Form of production

Storage conditions

Store in a dry place, protected from light, at a temperature not exceeding 30 °C

Shelf life

3 years

Active ingredient

Levocetirizine

Dosage form

Tablets

Description

For adults and Children over 6 years of age

Indications

Urticaria, Dermatosis, Allergic Conjunctivitis, Pollinosis, Neurodermatitis, Allergy