Glucose-Solopharm Politvist solution 400mg/ml 10ml ampoules, 10pcs

Composition

1 ml of the solution contains

the Active ingredient

dextrose monohydrate in terms of dry matter-400.0 mg

excipients:

hydrochloric acid 1 M solution to pH 3.0-4.0,

sodium chloride,

water for injection.

Pharmacological action

Pharmacotherapeutic group of carbohydrate-type nutrition. ATX code: B 05 BA 03 Pharmacological Properties Pharmacodynamics is involved in various metabolic processes in the body. Infusion of glucose solutions partially fills the water deficit. Dextrose, entering the tissues, is phosphorylated, turning into glucose-6-phosphate, which is actively involved in many parts of the body’s metabolism. Dextrose solution 400 mg / ml is hypertensive, increases osmotic blood pressure, dilates blood vessels, increases diuresis. Pharmacokinetics The bioavailability of glucose after intravenous use is 100%. Glucose is metabolized in two different ways: anaerobic and aerobic. Dextrose, breaking down into pyruvic or lactic acid (anaerobic glycolysis), is metabolized to carbon dioxide and water with the release of energy. Usually, glucose is completely absorbed and not excreted by the kidneys.

Indications

-Hypoglycemia. – As a source of carbohydrates (separately or as part of parenteral nutrition, if necessary).

Use during pregnancy and lactation

During pregnancy and lactation, the safety and efficacy of the drug has not been established. The use of the drug during pregnancy and lactation is possible only as prescribed by a doctor, if the intended benefit to the mother exceeds the potential risk to the fetus or child. 40% glucose solution during pregnancy and during breastfeeding can only be used under the supervision of a doctor.

Contraindications

Hypersensitivity to the components of the drug, hyperglycemia, hyperlactatemia, hyperhydration, postoperative glucose utilization disorders; circulatory disorders that threaten brain and lung edema; brain edema, pulmonary edema, acute left ventricular failure, hyperosmolar coma, childhood (without dilution), decompensated diabetes mellitus, dextrose intolerance, including metabolic stress. With caution, compensated chronic heart failure, chronic renal failure (oligo -, anuria), hyponatremia, diabetes mellitus.

Side effects

-violation of the ion balance

-hyperglycemia

-acute left ventricular failure

-fever

-hyperglycemic hyperosmolar coma

-violation of the water-electrolyte balance

– with an increase in the rate of use-osmotic diuresis with loss of water, electrolytes and the development of hyperosmolar coma

At the injection site – the development of infection, sometimes thrombophlebitis

With repeated use of the solution, violations of the functional state of the liver and depletion of the insular apparatus of the pancreas are possible.

Interaction

The combined use of catecholamines and steroids reduces glucose uptake. When mixing with other medicinal products, it is necessary to visually check them for incompatibilities. In the absence of compatibility studies, the drug should not be mixed with other drugs. Before adding any medicine, it is necessary to make sure that it is soluble and stable in water within the pH range of the drug. After adding a compatible drug to the preparation, the resulting solution should be administered immediately. Medicines with known incompatibilities should not be used. Dextrose solutions should not be administered through the same infusion system as for blood transfusion, as there is a possible risk of hemolysis and thrombosis.

How to take, course of use and dosage

Intravenously (drip). The concentration and dose of the administered solution depend on the patient’s age, body weight, and clinical condition. The use of the drug should be carried out under regular medical supervision. Clinical and biological parameters, in particular the concentration of glucose in the blood, as well as the water-salt balance should be carefully monitored. Adults and adolescents aged 15 years and older: the maximum daily dose is 15 ml per kg of body weight per day, which corresponds to 6 g of glucose per kg of body weight per day. The maximum infusion rate is 0.62 ml per kg of body weight per hour, which corresponds to 0.25 g of glucose per kg of body weight per hour. For a patient with a body weight of 70 kg, the maximum infusion rate is 43 ml per hour (glucose – 17.5 g per hour). Children: maximum daily dose: preterm children – 18 g of dextrose per kg of body weight, or 45 ml per kg of body weight; full – term children – 15 g of dextrose per kg of body weight, or 37.5 ml per kg of body weight; 1-2 years – 15 g per kg of body weight/37.5 ml per kg of body weight; 3-5 years – 12 g per kg of body weight/30 ml per kg of body weight; 6-10 years – 10 g per kg of body weight/up to 25 ml per kg of body weight; 11-14 years-8 g per kg of body weight/20 ml per kg of body weight bodies. When using in newborns, it is necessary to take into account the high osmolarity of the solution. Elderly patients: mainly use the recommended doses for adults, but caution should be exercised when determining the volume of fluid administered and the dose of dextrose in patients with heart or renal insufficiency. Patients with reduced glucose metabolism (for example, in the early postoperative or post-traumatic period, with hypoxia, or organ failure): blood glucose concentrations should be carefully monitored. To avoid hyperglycemia, do not exceed the level of possible glucose oxidation. For a more complete assimilation of dextrose, administered in large doses, short-acting insulin is prescribed simultaneously at the rate of 1 unit of insulin per 4-5 g of dextrose. Patients with diabetes mellitus receive dextrose under the control of its concentration in the blood and urine. Maximum volumes within the recommended dose range should be administered within 24 hours to avoid hemodelution. The maximum rate of infusion should not exceed the threshold for glucose utilization in the patient’s body, as this may lead to hyperglycemia. Depending on the patient’s clinical condition, the rate of use may be reduced to reduce the risk of osmotic diuresis

Overdose

Symptoms: hyperglycemia, glucosuria, hyperglycemic, hyperosmolar coma, hyperhydration, impaired water and electrolyte balance, fatty liver infiltration, acute left ventricular failure, ion balance disorder. Treatment: stop glucose use, enter short-acting insulin, symptomatic therapy

Special instructions

Glucose solution should not be administered quickly or for a long time. If chills occur during the infusion of the solution, the use should be stopped immediately. To prevent thrombophlebitis, it should be administered slowly, through large veins.

For a more complete and rapid assimilation of dextrose,4-5 units of short-acting insulin can be administered subcutaneously, at the rate of 1 unit of short-acting insulin per 4-5 g of dextrose.

Monitoring of the patient should include regular monitoring of blood glucose, water balance, plasma concentrations of eectrolites-in particular potassium-and acid-base balance.

It is not recommended to prescribe glucose solution in the acute period of severe traumatic brain injury, with acute cerebrovascular accident, as the drug can increase damage to brain structures and worsen the course of the disease (except in the case of correction of hypoglycemia).

In hypokalemia, the use of glucose solution should be combined simultaneously with the correction of potassium deficiency (due to the risk of increased hypokalemia).

In case of hypotonic dehydration, the use of the drug is indicated simultaneously with the introduction of hypertonic saline solutions.

In diabetic patients, dextrose is administered under the control of blood sugar and urine.

With renal failure, decompensated heart failure, hyponatremia, special care is required when prescribing glucose, monitoring of central hemodynamic parameters is necessary.

Use in pediatrics

It is not recommended to use 40% glucose solution in doses exceeding 1 ml/kg of body weight in newborns and premature infants, since there is a high risk of developing encephalopathy caused by the introduction of a hypertensive solution.

Pregnancy and lactation

Use during breastfeeding, taking into account the excess of the intended benefit to the mother and the potential risk to the child, provided that the electrolyte and fluid balance are controlled and are within physiological limits. It can be used if necessary with caution, in pregnant women with reduced glucose tolerance, under the control of blood glucose levels.

Features of the drug’s effect on the ability to drive a vehicle or potentially dangerous mechanisms.

The drug does not affect the ability to drive vehicles, mechanisms, as well as engage in potentially dangerous activities that require increased concentration of attention and speed of psychomotor reactions.

Form of production

Solution

Storage conditions

Store at a temperature not exceeding 25 ° C. Keep out of reach of children.

Shelf

life is 2 years. Do not use after the expiration date!

Active ingredient

Dextrose

Conditions of release from pharmacies

By prescription

Dosage form

solution for infusions

Purpose

Nursing mothers as prescribed by a doctor, Children as prescribed by a doctor, Adults as prescribed by a doctor, Pregnant women as prescribed by a doctor

Indications

Preparation of drug solutions, Hepatitis, Liver damage, Poisoning, Hypoglycemia, Syncope