Composition
>of 1 g of the drug contains: Active ingredients: Heparin sodium-500 ME*, Dimethyl sulfoxide-150.0 mg, Dexpanthenol-25.0 mg;Â Excipients Isopropanol-353.3 mg, Carbomer-940-10.0 mg, Macrogol glycerylhydroxystearate-10.0 mg, Trollamine-5.0 mg, Mountain pine oil-2.5 mg, Rosemary oil-2.0 mg, Lemon oil-0.5 mg, Purified water-438.6 mg. *1IU of sodium heparin-anticoagulant activity corresponding to the activity of 0.0077 mg of the II International Standard of Heparin (WHO).
Pharmacological action
Pharmacodynamiccombinated drug for external use. The effect of the drug is due to the active substances included in its composition. Heparin sodium is a direct-acting anticoagulant; due to the inactivation of biogenic amines and blocking of lysosomal enzymes in tissues, it has an anti-inflammatory effect; accelerates the dissolution of microthrombi in the subcutaneous capillaries; improves local blood flow; promotes the regeneration of connective tissue by inhibiting the activity of hyaluronidase. When applied topically, it also has a decongestant effect. Dexpanthenol (provitamin B5) has an anti-inflammatory and dermatoprotective effect; improving metabolic processes, it stimulates regeneration processes. By improving the processes of epithelialization and granulation, it promotes the regeneration of damaged tissues. Dimethyl sulfoxide has anti-inflammatory, local anesthetic, analgesic and antimicrobial effects; it has moderate fibrinolytic activity. Penetrates through the skin, mucous membranes, biological membranes, promotes deeper penetration into the tissues of other components of the drug. Pharmacokinetics Heparin sodium when applied externally quickly penetrates the skin: 1 hour after applying the gel to the skin, the concentration in the underlying tissues is comparable to the concentration observed after intravenous use (IV) of 5000 IU of heparin. Heparin does not cross the placental barrier and is not excreted in breast milk. Dexpanthenol-after resorption into the skin, it is converted into pantothenic acid (vitamin B5), which, as a component of coenzyme A, is involved in numerous metabolic processes. Dimethyl sulfoxide quickly penetrates through the skin, mucous membranes, and biological membranes (including microbial cell membranes). After application to the skin, the maximum plasma concentration is reached in 4-8 hours. It is evenly distributed in the body, with the exception of the brain, where its concentration is minimal. It is mainly excreted in the urine (30% of the dose in the form of unchanged drug and dimethylsulfone); to a small extent – through the lungs and intestines. The metabolite dimethyl sulfide causes a characteristic garlic breath odor in some patients.
Indications
- Bruises, inflammation of soft tissues, muscles, tendons, tendon sheaths, ligaments after bruises, squeezes, injuries (including sports).
- Scapular periarthritis, epicondylitis of the shoulder (“tennis player’s elbow”), tendinitis, tendovaginitis, bursitis, deforming osteoarthritis (in the presence of damage to periarticular tissues), neuralgia.
Contraindications
- Hypersensitivity to heparin, the sulfoxide, the dexpanthenol and other components of the drug;
- bronchial asthma;
- pregnancy, lactation;
- severe hepatic and/or renal failure;
- severe disorders of the cardiovascular system (including severe angina, myocardial infarction, stroke, expressed General atherosclerosis);
- lupus erythematosus;
- open wounds at the site of application of the drug;
- children up to age 5 years.
Side effects
Hyperemia, itching and burning of the skin in the application area; allergic reactions (urticaria, angioedema); garlic smell from the mouth; changes in taste sensations.
Interaction
The dimethyl sulfoxide included in the gel significantly enhances the penetration of other drugs through the skin. To prevent the undesirable effects of these substances, do not apply other drugs to the skin before or after applying Hepatrombin C.
How to take, course of use and dosage
Externally. The gel is applied in a thin layer to the affected areas of the skin or the skin above the painful area, trying to avoid applying the drug directly to wounds and abrasions. After applying the gel, do not apply a bandage. Before applying, the skin should be clean and dry. The procedure is repeated 1-2 times a day for 7-10 days or until the symptoms of the disease disappear (pain, swelling, inflammation). If there is no clear improvement within 10 days of applying the gel, it is recommended to consult a doctor.
Overdose
To date, cases of overdose of the drug Hepatrombin C have not been described. If the gel is applied correctly, overdose is unlikely.
Special instructions
It is not recommended to apply the gel on open wounds. If allergic skin reactions occur, treatment should be discontinued.
Form of production
Gel for external use (500IU + 150 mg + 25 mg)/g.
40 g of the drug in an aluminum tube, capped with a screw cap made of plastic. The tube opening is protected by an aluminum membrane. The lid is a monolithic structure that includes a device for piercing the membrane. Tube together with the instructions for use in a cardboard pack.
Storage conditions
Store at a temperature of 15 to 25°C. Keep out of reach of children!
Shelf
life is 5 years.
Do not use after the expiration date indicated on the package.
Active ingredient
Heparin Sodium, Dexpanthenol, Dimethyl Sulfoxide
Dosage form
gel for external use
Description
For adults and Children over 5 years of age
Indications
Swelling after injuries and operations, Varicose Veins, Hematomas, Bruises, Trigeminal Neuralgia
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Side effects of Hepatrombin C, gel 500me+25mg+150mg/g 40g.
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