Composition
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per 100 g of ointment contains:
Active ingredient:
hydrocortisone acetate-0.5 g;
excipients:
methylparahydroxybenzoate (methylparaben),
petroleum jelly.
Pharmacological action
Hydrocortisone is a natural glucocorticosteroid.
It has an anti-inflammatory, anti-allergic effect. Reduces inflammatory cell infiltrates, reduces the migration of white blood cells and lymphocytes in the area of inflammation.
Stabilizes cellular and subcellular, including lysosomal and mast cell membranes.
Reduces the binding of immunoglobulins to cell surface receptors and inhibits the synthesis or release of cytokines (interleukins and interferon) from lymphocytes and macrophages. Reduces the release of arachidonic acid from phospholipids and the synthesis of its metabolites (prostaglandins, leukotrienes, thromboxane).
Reduces exudative reaction, helps to reduce capillary permeability.
Reduces the severity of the early immunological response. It has a catabolic effect and inhibits the development of connective tissue and scarring.
Indications
- allergic eye diseases (eyelid dermatitis, blepharitis, conjunctivitis and keratoconjunctivitis);
- inflammatory eye diseases of the anterior part of the eye in the absence of violation of the integrity of the corneal epithelium (blepharitis, conjunctivitis and keratoconjunctivitis);
- thermal and chemical burns (after complete epithelialization of corneal defects).
Use during pregnancy and lactation
Studies on the safety and efficacy of hydrocortisone in pregnant and lactating women have not been conducted.
There are no exact data on the penetration of glucocorticosteroids into breast milk when applied topically.
However, the risk cannot be completely excluded.
The use of hydrocortisone in pregnant and lactating women is allowed only as prescribed by the attending physician, when the expected therapeutic effect for the mother exceeds the potential risk to the fetus and child.
Contraindications
- hypersensitivity to the components of the drug,
- purulent, viral, tuberculosis, fungal eye diseases;
- glaucoma;
- trachoma;
- vaccination period;
- violation of the integrity of the membranes of the eye
Side effects
Allergic reactions, burning sensation, injection of sclera, short-term blurred vision.
With prolonged use for more than 10 days, the following symptoms may occur: :
– increased intraocular pressure with the possible subsequent development of steroid glaucoma with damage to the optic nerve and impaired visual fields (therefore, when using drugs containing glucocorticosteroids, intraocular pressure should be measured regularly for more than 10 days);- formation of posterior subcapsular cataracts;- slowing down the healing process of wounds (in diseases that cause thinning of the cornea, its perforation is possible). Secondary bacterial infection can occur as a result of suppressing the protective reaction of the patient’s body. In acute purulent diseases of the eye, glucocorticosteroids can mask or enhance the existing infectious process.
Fungal corneal lesions tend to occur especially frequently with prolonged use of glucocorticosteroids. The appearance of non-healing ulcers on the cornea after prolonged treatment with glucocorticosteroids may indicate the development of fungal invasion.
Interaction
Barbiturates weaken the effect, diuretics increase hypokalemia. Reduces the effect of hypoglycemic agents.
With prolonged use of the drug with possible resorption of the drug into the general bloodstream, hydrocortisone reduces the effectiveness of insulin, oral hypoglycemic drugs, antihypertensive agents, anticoagulants, reduces the concentration of salicylates in the blood, reduces the concentration of praziquantel in the blood serum.
Increase the risk of side effects of hydrocortisone: androgens, estrogens, oral contraceptives, anabolic steroids (hirsutism, acne); antipsychotics, carbutamide, azathioprine (cataracts); holinoblockers, antihistamines, tricyclic antidepressants, nitrates (glaucoma); diuretics (hypokalemia).
When used with cardiac glycosides, digitalis intoxication may develop. Simultaneous use with lead and silver preparations leads to mutual inactivation.
How to take, course of use and dosage
Eye ointment: topically applied. 1-2 cm of eye ointment is injected into the conjunctival sac 2-3 times a day.
The course of treatment is 1-2 weeks. The course of treatment may be extended on the doctor’s recommendation.
Special instructions
Contact lenses are not recommended during treatment. When using eye drops, the time interval between instillation and application of the ointment is at least 15 minutes. If used for more than 10 days and there is a history of open – or closed-angle glaucoma, monitoring of intraocular pressure is necessary. Shelf life after opening the tube is 1 month. Influence on the ability to drive motor vehicles and manage mechanisms. If the patient’s visual clarity is temporarily reduced after using the drug, it is not recommended to drive a car or engage in activities that require visual clarity until it is restored.
Form of production
Eye ointment
Storage conditions
In a place protected from light, at a temperature not exceeding 15 °C. (do not freeze).
Active ingredient
Hydrocortisone
Dosage form
ointment
Description
Children as prescribed by a doctor, For adults, Nursing mothers as prescribed by a doctor, Pregnant women as prescribed by a doctor
Indications
Conjunctivitis, Inflammatory eye diseases, Blepharitis, Iridocyclitis, Barley on the eye, Allergy
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Side effects of Hydrocortisone, eye ointment 0.5%, 5g.
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