Ibuprofen, pills 200mg, 20pcs

Composition

1 tablet contains:

Active ingredient:

ibuprofen 200 mg

Pharmacological action

Pharmaceutical Group:

NSAIDs.

Pharmaceutical action:  

NSAIDs; has analgesic, antipyretic and anti-inflammatory effects due to the indiscriminate blockade of COX 1 and COX 2 and have an inhibitory effect on Pg synthesis.

The analgesic effect is most pronounced in inflammatory pain. Like all NSAIDs, ibuprofen has antiplatelet activity.

Indications

Inflammatory and degenerative diseases of the musculoskeletal system: rheumatoid, juvenile chronic, psoriatic arthritis, osteochondrosis, neuralgic amyotrophy (Personage-Turner disease), arthritis in SLE (as part of complex therapy), gouty arthritis (with an acute attack of gout, fast-acting dosage forms are preferred), ankylosing spondylitis (Ankylosing spondylitis).

Pain syndrome: myalgia, arthralgia, ossalgia, arthritis, sciatica, migraine, headache (including menstrual syndrome) and toothache, cancer, neuralgia, tendinitis, tendovaginitis, bursitis, neuralgic amyotrophy (Personage-Turner disease), post-traumatic and postoperative pain syndrome accompanied by inflammation.

Algodismenorrhea, pelvic inflammatory process, including adnexitis, childbirth (as an analgesic and tocolytic agent).

Febrile syndrome in “colds” and infectious diseases.

It is intended for symptomatic therapy, reducing pain and inflammation at the time of use, and does not affect the progression of the disease.

Contraindications

• Hypersensitivity to any of the ingredients that make up the drug. History of hypersensitivity to acetylsalicylic acid or other NSAIDs.

• Erosive and ulcerative diseases of the gastrointestinal tract (including peptic ulcer of the stomach and duodenum in the acute stage, Crohn’s disease, ulcerative colitis).

• “Aspirin” asthma.

• Hemophilia and other blood clotting disorders (including hypocoagulation), hemorrhagic diathesis.

• Bleeding of any etiology.

• Glucose-6-phosphate dehydrogenase deficiency.

• Pregnancy (third trimester), lactation period.

• Children under 12 years of age.

• Diseases of the optic nerve.

Side effects

• : heartburn, abdominal pain, nausea, vomiting, diarrhea, flatulence, anorexia, NSAIDs-gastropathy, gastrointestinal bleeding.
• headache, dizziness, insomnia or drowsiness, agitation, depression, tinnitus, visual acuity disorders (color vision disorders, scotoma, amblyopia).
• allergic skin reactions, urticaria, angioedema, erythema multiforme (Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell’s syndrome), aseptic meningitis, bronchospasm.
• heart failure, tachycardia, increased blood pressure,
• edematous syndrome, impaired renal function, allergic nephritis.
• anemia, thrombocytopenia, agranulocytosis, leukopenia.
• increased sweating.

Interaction

Ibuprofen may increase plasma concentrations of methotrexate, lithium, and digoxin when co-administered with these drugs.

Ibuprofen, like other nonsteroidal anti-inflammatory drugs (NSAIDs), can reduce the effect of diuretics, calcium channel blockers, ACE inhibitors and other antihypertensive drugs, which is associated with impaired prostaglandin synthesis in the kidneys. Concomitant use with potassium-sparing diuretics may lead to an increase in the level of potassium in the blood (if necessary, such a combination of drugs should monitor the level of potassium in the plasma).

There are reports of an increased risk of bleeding in the case of combined use of ibuprofen and anticoagulants, fibrinolytic drugs.

When combined with antidepressants, barbiturates, zixorin, rifampicin, phenylbutazone, and phenytoin, the risk of severe intoxication increases due to increased production of hydroxylated active metabolites of ibuprofen.

Ibuprofen increases the hypoglycemic effect of oral hypoglycemic agents, which requires dose adjustment of these drugs against the background of ibuprofen use.

Glucocorticoid and mineral corticoid hormones, colchicine enhance the anti-inflammatory effect of ibuprofen and increase the risk of developing gastrointestinal tract damage.

When combined with cefamandol, cefoperazone, cefotetane, valproic acid and plicamycin, the risk of hypoprothrombinemia increases.

Cyclosporine and gold preparations enhance the nephrotoxic effect of ibuprofen.

Ibuprofen increases the undesirable effect of estrogens when used together.

Ibuprofen weakens the effectiveness of the uricosuric action of anti-gouty drugs.

Colestyramine slows down the absorption of ibuprofen.

Caffeine enhances the analgesic effect of ibuprofen.

Ibuprofen increases the toxicity of ethanol.

When used together, acetylsalicylic acid weakens the effect of ibuprofen and increases its toxicity, this is due to the displacement of ibuprofen from protein binding and its metabolism with the formation of toxic hydroxylated metabolites.

How to take, course of use and dosage

of Ibuprofen is taken orally, after meals. The dosage regimen is set individually depending on the indications. Adults and children over 12 years of age are usually prescribed the drug in an initial dose of 200 mg 3-4 times a day. To achieve a rapid therapeutic effect, the dose can be increased to 400 mg 3 times a day. When the therapeutic effect is achieved, the daily dose is reduced to 600-800 mg.

On the doctor’s recommendation, for osteoarthritis, psoriatic arthritis and ankylosing spondylitis-400-600 mg 3-4 times a day. For rheumatoid arthritis-800 mg 3 times a day; for soft tissue injuries, ligament injuries up to 2.4 g / day in several doses. With primary dysmenorrhea-400 mg 3-4 times a day; with moderate pain syndrome -1.2 g/day.

For juvenile rheumatoid arthritis – 30-40 mg / kg / day in several doses.

Overdose

Symptoms: a typical clinical picture of an ibuprofen overdose does not develop. Abdominal pain, nausea, vomiting, dizziness, lethargy, drowsiness, depression, headache, hypotension, convulsions, cardiac arrhythmias, acute renal failure, respiratory depression may occur.

Treatment: relief measures include drug withdrawal, maintenance and symptomatic therapy aimed at eliminating the resulting disorders, and correction of the acid-base state. It is possible to perform forced diuresis with simultaneous use of alkaline drinking, activated carbon, to reduce the reabsorption of ibuprofen.

There is no specific antidote. Gastric lavage is effective only within an hour after taking the drug.

Special instructions

for people with gastrointestinal disorders. During the use of ibuprofen, careful medical monitoring is necessary for patients who have complaints from the gastrointestinal tract, a history of ulcerative lesions of the gastrointestinal tract, as well as non-specific ulcerative colitis or Crohn’s disease. When using ibuprofen, this group of patients may experience (for the first time or repeatedly) gastrointestinal bleeding or ulceration/perforation of the gastrointestinal tract, which may not be accompanied by harbinger symptoms. In all such cases, the drug should be discontinued.

Persons with pathology of the blood system. Ibuprofen temporarily inhibits platelet aggregation, so careful monitoring of appropriate laboratory parameters is necessary in patients with impaired hemostasis. With prolonged use of ibuprofen, systematic monitoring of peripheral blood is indicated.

Individuals with liver diseases. During the use of ibuprofen, a transient increase in the activity of liver enzymes is possible. Laboratory monitoring of liver function is indicated as a precautionary measure during long-term ibuprofen therapy. If functional disorders persist or worsen, or if there are clinical manifestations of other liver disorders, ibuprofen should be discontinued. It should be remembered that hepatitis with ibuprofen can occur without prodromal manifestations.

Persons with pathology of the cardiovascular system. Since prostaglandins play an important role in maintaining normal renal blood flow, special care is required when using ibuprofen in patients suffering from impaired renal function and chronic congestive heart failure, in people receiving diuretics, as well as in patients with a significant decrease in the volume of circulating plasma (for example, in the period before and after massive surgical interventions). In all these cases, monitoring of renal function is recommended as a precautionary measure. Discontinuation of the drug usually leads to the restoration of renal function to the initial level.

Influence on laboratory parameters. If it is necessary to determine 17-ketosteroids in the urine, ibuprofen should be discontinued 48 hours before the test.

Influence on the ability to drive motor vehicles and manage mechanisms. During the period of using ibuprofen, it is necessary to refrain from all activities that require increased attention, rapid mental and motor reactions.

During the treatment period, it is not recommended to take ethanol.

Cherry and currant juice, sugar syrup increase the rate of absorption of ibuprofen.

To reduce the risk of gastrointestinal adverse events, the minimum effective dose should be used in the shortest possible course.

Form of production

Coated tablets.

Storage conditions

In a dry place, protected from light

Shelf life

3 years

Active ingredient

Ibuprofen

Dosage form

Tablets