Ibuprofen Wellfarm pills 400mg, 20pcs

Composition

Per tablet:

Active ingredient: ibuprofen-400.0 mg;

Excipients: povidone K 90 (collidone 90 F), microcrystalline cellulose MS-101, talc, crospovidone (collidone CL, collidone CL-M), calcium stearate, colloidal silicon dioxide (aerosil), corn starch.

Shell composition: [dry mixture for film coating containing hypromellose, titanium dioxide, macrogol or hypromellose (hydroxypropylmethylcellulose), titanium dioxide, macrogol 6000 (polyethylene glycol 6000, polyethylene oxide 6000)

Pharmacological action

Pharmacotherapy group: nonsteroidal anti-inflammatory drug (NSAID).

ATX code: M 01 AE 01

Pharmacological properties

Pharmacodynamics

The mechanism of action of ibuprofen, a propionic acid derivative from the group of nonsteroidal anti-inflammatory drugs, is due to inhibition of the synthesis of prostaglandins – mediators of pain, inflammation and hyperthermic reaction. It selectively blocks cyclooxygenase 1 (COX-1) and cyclooxygenase 2 (COX-2), thereby inhibiting prostaglandin synthesis. It has a rapid directed action against pain (analgesic), antipyretic and anti-inflammatory effect. In addition, ibuprofen reversibly inhibits platelet aggregation. The analgesic effect of the drug lasts up to 8 hours.

Pharmacokinetics

Ibuprofen is rapidly and almost completely absorbed from the gastrointestinal tract, its maximum plasma concentrations are reached 1-2 hours after oral use, in synovial fluid – after 3 hours, binds to plasma proteins by 99%.

Slowly penetrates the joint cavity, lingers in the synovial tissue, creating higher concentrations in it than in plasma.

Ibuprofen is primarily metabolized in the liver. The plasma half-life (T 1/2) is 2-3 hours. It is excreted by the kidneys in the form of metabolites (no more than 1% is excreted unchanged), to a lesser extent – with bile. Ibuprofen is completely eliminated in 24 hours.

Indications

Ibuprofen is used for headache, migraine, toothache, painful menstruation, neuralgia, back pain, muscle pain, rheumatic pain and joint pain; as well as for fever in flu and colds.

Contraindications

– hypersensitivity to ibuprofen or any of the components included in the composition of the drug;

– complete or incomplete combination of bronchial asthma, recurrent polyposis of the nose and paranasal sinuses and intolerance of acetylsalicylic acid or other NSAIDs (including in the anamnesis);

– erosive and ulcerative diseases of the gastrointestinal tract (including stomach ulcer and duodenal ulcer, Crohn’s disease, ulcerative colitis) ulcer or bleeding in the active phase or in history (two or more confirmed – tion of an episode of peptic ulcer or ulcer bleeding);

a bleeding or perforated ulcer of the gastrointestinal tract in history, triggered by the use of NSAIDs;

– severe liver failure or liver disease in the active phase;

– severe renal failure severity (creatinine clearance < 30 ml/min), confirmed hyperkalemia;

decompensated heart failure; after the coronary artery bypass grafting;

– cerebrovascular or other bleeding;

– hemophilia and other blood clotting (including anticoagulation), hemorrhagic diathesis;

– pregnancy (III trimester);

– children’s age up to 6 years for tablets 200 mg; up to 12 for tablets 400 mg.

With caution

If you have any of the conditions listed in this section, you should consult your doctor before using the drug.

Concomitant use of other NSAIDs, a history of a single episode of gastric and duodenal ulcer or ulcerative bleeding of the gastrointestinal tract; gastritis, enteritis, colitis, Helicobacter pylori infection, ulcerative colitis; bronchial asthma or allergic diseases in the acute stage or in the anamnesis – may develop bronchospasm; systemic lupus erythematosus or mixed connective tissue disease (Sharp’s syndrome) – increased risk aseptic meningitis; renal failure, including dehydration (creatinine clearance less than 30-60 ml/min), nephrotic syndrome, hepatic insufficiency, cirrhosis of the liver with portal hypertension, hyperbilirubinemia, arterial hypertension and/or heart failure, cerebrovascular diseases, blood diseases of unknown etiology (leukopenia and anemia), severe somatic diseases, dyslipidemia/hyperlipidemia, diseases of the liver and / or other diseases of the liver. peripheral artery diseases, smoking, frequent alcohol consumption, phenylketonuria or intolerance to phenylalanine, concomitant use of medications that may increase the risk of ulceration or bleeding, in particular, oral glucocorticosteroids (including prednisone), anticoagulants (including warfarin), selective serotonin reuptake inhibitors (including acetylsalicylic acid, clopidogrel), pregnancy I-II trimester, period breast – feeding, still living age.

Side effects

The risk of side effects can be minimized by taking the drug in a short course, at the minimum effective dose necessary to eliminate symptoms.

Elderly people have an increased frequency of adverse reactions associated with NSAID use, especially gastrointestinal bleeding and perforation, in some cases with a fatal outcome.

Side effects are mostly dose-dependent. In particular, the risk of gastrointestinal bleeding depends on the dose range and duration of treatment.

The following adverse reactions were observed with short-term use of ibuprofen in doses not exceeding 1200 mg / day (6 tablets-200 mg; 3 tablets-400 mg). In the treatment of chronic conditions and with prolonged use, other adverse reactions may occur.

The frequency of adverse reactions is estimated based on the following criteria: very frequent (≥ 1/10), frequent (≥ 1/100 to < 1/10), infrequent (≥1/1000 to < 1/100), rare (≥1/10000 to < 1/1000), very rare (

Disorders of the blood and lymphatic system

Very rare: hematopoietic disorders (anemia, leukopenia, aplastic anemia, hemolytic anemia, thrombocytopenia, pancytopenia, agranulocytosis). The first symptoms of such disorders are fever, sore throat, superficial ulcers in the mouth, flu-like symptoms, severe weakness, nosebleeds and subcutaneous hemorrhages, bleeding and bruising of unknown etiology.

Immune system disorders

Infrequent: hypersensitivity reactions – non – specific allergic reactions and anaphylactic reactions, respiratory tract reactions (bronchial asthma, including its exacerbation, bronchospasm, shortness of breath, dyspnoea), skin reactions (pruritus, urticaria, purpura, Quincke’s edema, exfoliative and bullous dermatoses, including toxic epidermal necrolysis (Lyell’s syndrome), Stevens-Johnson syndrome, multi – functional hypersensitivity reactions). – erythema forma), allergic rhinitis, eosinophilia.

Very rare: severe hypersensitivity reactions, including swelling of the face, tongue and larynx, shortness of breath, tachycardia, hypotension (anaphylaxis, angioedema or severe anaphylactic shock).

Disorders of the gastrointestinal tract

Infrequent: abdominal pain, nausea, dyspepsia (including heartburn, bloating).

Rare: diarrhea, flatulence, constipation, vomiting.

Very rare: peptic ulcer, perforation or gastrointestinal bleeding, melena, bloody vomiting, in some cases fatal, especially in elderly patients, ulcerative stomatitis, gastritis.

Frequency unknown: exacerbation of colitis and Crohn’s disease.

Liver and biliary tract disorders

Very rare: liver function disorders, increased activity of “hepatic” transaminases, hepatitis and jaundice.

Kidney and urinary tract disorders

Very rare: acute renal failure (compensated and decompensated), especially with prolonged use, in combination with increased urea concentration in blood plasma and the appearance of edema, hematuria and proteinuria, nephritic syndrome, nephrotic syndrome, papillary necrosis, interstitial nephritis, cystitis.

Nervous system disorders

Infrequent: headache.

Very rare: aseptic meningitis.

Disorders of the cardiovascular system

The frequency is unknown: heart failure, peripheral edema, prolonged use increases the risk of thrombotic complications (for example, myocardial infarction), increased blood pressure.

Respiratory and mediastinal disorders

Frequency unknown: bronchial asthma, bronchospasm, shortness of breath.

Laboratory parameters

– hematocrit or hemoglobin (may decrease);

– bleeding time (may increase);

– plasma glucose concentration (may decrease);

– creatinine clearance (may decrease);

– plasma creatinine concentration (may increase);

– activity of