Iodopyron, solution 1% vial 100ml

Composition

Active ingredients:

iodine 14.1 g;

Auxiliary substances:

potassium iodide 13.8 g,

povidone low molecular weight 122.1 g,

purified water up to 1000 ml

Pharmacological action

Iodopirone is an antiseptic, when applied externally it has a bactericidal (against a wide range of gram-positive and gram-negative microorganisms, including antibiotic-resistant strains of Escherichia coli, Staphylococcus aureus and proteus), fungicidal and anti-inflammatory effect.

Elemental iodine has pronounced antimicrobial properties. Elemental iodine preparations are characterized by a pronounced local irritant effect on tissues, and in high concentrations – a cauterizing effect. Local action is due to the ability of elemental iodine to precipitate tissue proteins. Preparations that cleave off elemental iodine have a much less pronounced irritating effect, and iodides have local irritating properties only in very high concentrations.

The nature of the resorptive action of elemental iodine and iodide preparations is the same. The most pronounced effect of resorptive action of iodine preparations have on the thyroid function. If there is insufficient iodine, iodides help restore the disturbed synthesis of thyroid hormones. When the iodine content in the environment is normal, iodides inhibit the synthesis of thyroid hormones, the sensitivity of the thyroid gland to TSH of the pituitary gland decreases, and its secretion by the pituitary gland is blocked.

The effect of iodine preparations on metabolism is manifested by an increase in dissimilation processes. In atherosclerosis, they cause a slight decrease in the concentration of cholesterol and beta-lipoproteins in the blood; in addition, they increase the fibrinolytic and lipoproteinase activity of blood serum and slow down the blood clotting rate.

Accumulating in syphilitic gummies, iodine contributes to their softening and resorption. However, the accumulation of iodine in tuberculosis foci leads to an increase in the inflammatory process in them. The excretion of iodine by the excretory glands is accompanied by irritation of the glandular tissue and increased secretion. This is due to the expectorant effect and stimulation of lactation (in small doses). However, in large doses, iodine preparations can cause lactation depression.

Pharmacokinetics

Upon contact with the skin or mucous membranes,30% is converted to iodides, and the rest is converted to active iodine. Partially absorbed. The absorbed part penetrates into tissues and organs, and is selectively absorbed by the thyroid gland. It is secreted mainly by the kidneys, intestines, sweat and mammary glands.

Indications

For external use: infectious and inflammatory skin lesions, injuries, wounds, myalgia.

For topical use: chronic tonsillitis, atrophic rhinitis, purulent otitis media, trophic and varicose ulcers, wounds, infected burns, fresh thermal and chemical burns of I-II degrees.

For oral use: prevention and treatment of atherosclerosis, tertiary syphilis.

Contraindications

Individual intolerance to iodine.

For oral use-pulmonary tuberculosis, nephritis, nephrosis, adenomas (including thyroid gland), furunculosis, acne, chronic pyoderma, hemorrhagic diathesis, urticaria, pregnancy, children under 5 years of age.

Side effects

 For external use: rarely-skin irritation; with prolonged use on extensive wound surfaces-iodism (rhinitis, urticaria, angioedema, salivation, lacrimation, acne).

When taken orally: allergic skin reactions, tachycardia, nervousness, sleep disorders, increased sweating, diarrhea (in patients over 40 years of age).

Interaction

Pharmacologically incompatible with essential oils, ammonia solutions, white sedimentary mercury (explosive mixture is formed). An alkaline or acidic environment, the presence of fat, pus, and blood weaken the antiseptic activity.

Weakens the hypothyroid and strumogenic effects of lithium preparations.

How to take, course of use and dosage

 When applied externally, iodine is used to treat damaged skin areas.

For oral use, the dose is set individually, depending on the indications and age of the patient.

Topically used for washing lacunae and supratonsillar spaces-4-5 procedures at intervals of 2-3 days, for irrigation of the nasopharynx-2-3 times a week for 2-3 months, for instillation in the ear and washing – for 2-4 weeks; in surgical practice and for burns, gauze napkins applied to the affected surface are wetted as needed.

Special instructions

With prolonged use, the phenomena of iodism are possible.

For nephritis and nephrosis, it is contraindicated for oral use.

Form of production

Iodopirone solution 1%

Storage conditions

Store in a dry place, protected from light and out of reach of children.

See expiration date. on the packaging.

Active ingredient

Povidone-Iodine, Potassium Iodide

Dosage form

solution for external use