Composition
Active ingredient: Â
Povidone-iodine (povidone-iodine 30/06) — 200.0 mg (with povidone-iodine activity of 11%; in the case of other drug activity, the amount of the base is reduced or increased accordingly);
Auxiliary substances: Â
Polyethylene oxide base: Â
Macrogol-1500 (polyethylene oxide-1500) — 2.66 g,
Macrogol-400 (polyethylene oxide-400) — 0.14 g.
Pharmacological action
An antiseptic drug. Blocks amino groups of cellular proteins. It has a wide spectrum of antimicrobial action. Active against bacteria (including Escherichia coli, Staphylococcus aureus), fungi, viruses, protozoa. The Active ingredient of the drug — iodine-is in the form of a complex with polyvinylpyrrolidone (povidone), which belongs to iodophores that bind iodine. The concentration of active iodine is 0.1-1%. Upon contact with the skin and mucous membranes, iodine is gradually and evenly released, exerting a bactericidal effect on microorganisms. At the site of application, a thin colored layer remains, which remains until the entire amount of iodine is released. Absorption and distributionw Hen povidone-iodine comes into contact with the mucous membrane, it is possible to absorb iodine and increase its content in the blood (the concentration returns to its original value 7-14 days after the last use of the drug). In patients with normal thyroid function, increased iodine absorption does not cause significant changes in its hormonal function. Excretion Iod is mainly excreted by the kidneys. The half-life (T1/2) after intravaginal use is approximately 48 hours.
Indications
- acute and chronic infectious and inflammatory diseases of the vagina (trichomonas, fungal, viral, non-specific, mixed infections);
- bacterial vaginitis;
- prevention of infectious and inflammatory complications before gynecological interventions (artificial termination of pregnancy, installation and removal of the intrauterine device, diathermocoagulation of the cervix, hysterosalpingography, and others).
Contraindications
- hypersensitivity to the components of the drug;
- thyrotoxicosis;
- herpetiform dermatitis Duhring;
- thyroid adenoma;
- simultaneous therapy with radioactive iodine;
- neonatal period (especially in premature infants).
With caution:
- chronic renal failure;
- pregnancy (II and III trimester);
- breast-feeding.
Side effects
Hypersensitivity reactions to the drug at the site of application: hyperemia, pruritus. Allergic reactions are possible, including contact dermatitis with the formation of psoriasis-like red small bullous elements. If such phenomena occur, the drug should be discontinued.
Interaction
Povidone-iodine is incompatible with oxidizing agents, alkali salts and substances with an acidic reaction. It is not recommended to use povidone-iodine simultaneously with hydrogen peroxide and products containing mercury, silver and enzymes.
How to take, course of use and dosage
Intravaginally. Insert deep into the vagina, lying on your back.
For acute vaginitis-1 suppository 2 times a day for 7 days; for subacute and chronic vaginitis-1 suppository 1 time a day before bedtime for 14 days (regardless of the phase of the menstrual cycle).
If necessary, the course of treatment can be extended.
Special instructions
In the presence of blood, the bactericidal effect of povidone-iodine may decrease. In the case of non-manifest hyperthyroidism and other thyroid diseases (especially in elderly patients), the drug is used only under strict indications and under constant medical supervision. Due to the oxidative properties of povidone-iodine, traces of it can lead to false positive results for some types of tests to detect hidden blood in the stool, as well as blood or glucose in the urine. During the use of povidone-iodine, the absorption of iodine by the thyroid gland may decrease, which may affect the results of certain diagnostic studies (for example, thyroid scintigraphy, determination of protein-bound iodine, measurements using radioactive iodine), and interaction with iodine preparations used to treat thyroid diseases is also possible. To obtain undistorted results of thyroid scintigraphy after long-term therapy with povidone-iodine, it is recommended to maintain a sufficiently long period of time without this drug. If symptoms of hyperthyroidism occur during the course of treatment, it is necessary to check the function of the thyroid gland. Caution should be exercised when using the drug regularly in patients with previously diagnosed renal insufficiency. Regular use of Iodoxide® should be avoided in patients receiving lithium preparations. Caution is recommended when administering vaginal suppositories to virgins. Staining on leather and fabrics is easily washed off with water. Suppositories have a spermicidal effect, and therefore their use in persons planning pregnancy is not recommended. During the use of suppositories, the use of sanitary pads can be recommended. After contact with the drug, avoid contact with the eyes. Influence on the ability to drive vehicles and work with mechanicsmi Ne affects the ability to drive a car and other mechanisms.
Product form
vaginal suppositories
Storage conditions
In a dark place at a temperature not exceeding 25 °C. Keep out of reach of children.
Shelf
life is 3 years. Do not use the product after the expiration date indicated on the package.
Active ingredient
Povidone-Iodine
Dosage form
vaginal suppositories
Description
For pregnant and lactating women, For adults
Indications
From thrush, From trichomoniasis, Vaginitis, From inflammation of the female genital organs
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Side effects of Iodoxide, vaginal suppositories 200mg 10pcs.
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