Kestine, pills 10mg, 5pcs

Composition

Active ingredient:

Ebastine microionized 10 mg.

Auxiliary substances:

microcrystalline cellulose,

corn starch,

lactose monohydrate,

sodium carboxymethylcellulose structured,

magnesium stearate,

hydroxypropylmethylcellulose,

polyethylene glycol 6000,

titanium dioxide.

Pharmacological action

Pharmacodynamics

An anti-allergic drug. After taking the drug inside, the pronounced anti-allergic effect begins in 1 hour and lasts for 48 hours. After a 5-day course of treatment with Kestine®, antihistamine activity persists for 72 hours due to the action of active metabolites. The drug does not have a pronounced anticholinergic and sedative effect. There was no effect of Kestine® on the ECG QT interval at a dose of 100 mg exceeding the recommended daily dose by 5-10 times.

Pharmacokinetics

After oral use, it is rapidly absorbed and almost completely metabolized in the liver, turning into the active metabolite of carbastine. After a single dose of 10 mg of the drug, the Cmax of carbastine in plasma is reached in 2.6-4 hours and is 80-100 ng / ml. It does not penetrate the blood-brain barrier.

With a daily intake of 10 mg of the drug, the equilibrium concentration is reached in 3-5 days and is 130-160 ng / ml. The binding to plasma proteins of Ebastine and carbastin is more than 95%. T1 / 2 of carbastine is from 15 to 19 hours,66% of the drug is excreted as conjugates through the kidneys.

Food intake does not affect the clinical effects of Kestine®.

In elderly patients, the pharmacokinetic parameters do not change significantly. With renal insufficiency, T1 / 2 increases to 23-26 hours, and with hepatic insufficiency-up to 27 hours, but the concentration of the drug does not exceed therapeutic values.

Indications

Allergic rhinitis of various etiologies (seasonal and/or year-round, both accompanied and not accompanied by allergic conjunctivitis).

Urticaria of various etiologies, including chronic idiopathic.

Use during pregnancy and lactation

Contraindicated during pregnancy and lactation.

Contraindications

• Hypersensitivity to the components of the drug;
• pregnancy and lactation;
• children under 12 years of age;
• lactase deficiency, lactose intolerance, glucose-galactose malabsorption.

Caution: use in patients with prolonged QT interval, hypokalemia, renal and / or hepatic insufficiency.

Side effects

With a frequency of more than 1%: headache (7.9%), drowsiness (3.0%), dryness of the oral mucosa (2.1%).

With a frequency of less than 1%: dyspepsia, nausea, insomnia, abdominal pain, asthenic syndrome, sinusitis, rhinitis.

Interaction

It is not recommended to use Kestine® concomitantly with ketoconazole and erythromycin (increased risk of prolongation of the QT interval).

Kestine® does not interact with theophylline, indirect anticoagulants, cimetidine, diazepam, ethanol and ethanol-containing drugs.

How to take, course of use and dosage

Inside, regardless of food intake.

• Adults and children over 12 years of age: prescribe 10-20 mg (1-2 tablets) of the drug once a day.

If liver function is impaired, the daily dose should not exceed 10 mg.

Overdose

Symptoms: signs of moderate effects on the central nervous system (fatigue) and the autonomic nervous system (dryness of the oral mucosa) can occur only at high doses (300 mg-500 mg, which is 30-50 times higher than the therapeutic dose).

Treatment: There is no specific antidote for Ebastine. In case of overdose, gastric lavage, monitoring of vital body functions, and symptomatic treatment are recommended.

Special instructions

Influence on the ability to drive vehicles and other mechanisms that require increased concentration of attention

In the event of side effects from the central nervous system, a minimal decrease in the ability of patients to drive vehicles and engage in other potentially dangerous activities that require increased concentration of attention and speed of psychomotor reactions is possible.

Form of production

Film-coated tablets

Storage conditions

In a dark place, at a temperature not exceeding 30 °C

Shelf life

3 years

Active ingredient

Abastin

Dosage form

Tablets

Description

For adults, Children over 12 years of age

Indications

Allergic Conjunctivitis, Allergic Rhinitis, Urticaria, Allergy