Ketoconazole suppositories vaginal 400mg, 10pcs

Composition

1 suppository contains:

Active ingredient:

ketoconazole 400 mg;

excipients:

butylhydroxyanisole 0.5 mg,

semi-synthetic glycerides (AM Suppository) – sufficient amount to obtain a suppository weighing 2000 mg

Pharmacological action

The Active ingredient is ketoconazole, a derivative of imidazoldioxolan.

It has a fungicidal and fungostatic effect against dermatophytes (Trichophyton spp., Epidermophyton floccosum, Microsporum spp. ) and yeast fungi (Pityrosporum spp., Candida spp. (including Candida albicans).

The mechanism of action consists in inhibiting the biosynthesis of ergosterol and changing the lipid composition of the fungal membrane.

The drug is active against staphylococci and streptococci.

Indications

Treatment of acute and chronic recurrent vaginal mycosis.

Prevention of the occurrence of fungal infections of the vagina with reduced resistance of the body and against the background of treatment with antibacterial agents and other drugs that violate the normal microflora of the vagina.

Contraindications

Hypersensitivity to the components of the drug, pregnancy, lactation.

Side effects

Hyperemia and irritation of the vaginal mucosa, itching of the vagina.

Allergic reactions: skin rash, urticaria.

Interaction

When used concomitantly with rifampicin and isoniazid, the concentration of ketoconazole in plasma decreases. When used concomitantly with cyclosporine, indirect anticoagulants and methylprednisolone, ketoconazole may increase the concentration of the latter in plasma.

Ethanol and other hepatotoxic drugs increase the risk of developing hepatic parenchyma. Increases the concentration of sulfonylurea derivatives and increases the risk of hypoglycemia.

Reduces the effect of amphotericin B. Increases plasma concentrations of digoxin, midazolam and triazolam. Increases the bioavailability of indinavir.

Reduces the stimulating effect of corticotropin on the adrenal glands. When combined with terfenadine, astemizole and cisapride, it increases the risk of severe ventricular tachycardia, including the pirouette type.

Increases the risk of “breakthrough” bleeding with simultaneous use of oral contraceptives with a low hormone content. Increases the toxicity of phenytoin.

How to take, course of use and dosage

The drug is used intravaginally, i. e. injected into the vagina.

To remove the suppository from the cell package, break off one cell with the suppository along the notch and disconnect the edges of the tape, pull them in different directions. Insert the suppository into the vagina with a pointed end, as deep as possible.

To prevent fungal lesions, use suppositories at a dose of 200 mg 1 time a day for 10 days.

For the treatment of thrush-suppositories at a dose of 200 mg 2 times a day or suppositories at a dose of 400 mg 1 time a day for 3 days.

For mycoses of the genital organs, acute and chronic vaginal candidiasis-suppositories at a dose of 200 mg 2 times a day or suppositories at a dose of 400 mg 1 time a day for 5 days.

If necessary, you can combine the use of tablets (inside) and suppositories (intravaginally).

Overdose

Due to the low absorption of the drug with intravaginal use in the recommended (therapeutic) doses, overdose is unlikely.

If the drug is accidentally taken orally, symptoms of poisoning may occur.

There is no specific antidote.

If necessary, take activated charcoal and perform symptomatic treatment.

Special instructions

During treatment, it is necessary to regularly monitor the picture of peripheral blood, the functional state of the liver and kidneys.

Avoid contact with latex preparations (contraceptive diaphragms, condoms.

Form of production

Suppositories are shaped like a cylinder with a pointed end, white or white with a yellowish tinge of color. An air rod or funnel-shaped recess is allowed on the cut.

Storage conditions

 In a dark place, at a temperature not exceeding 25 °C.

Shelf life

2 years

Active ingredient

Ketoconazole

Dosage form

vaginal suppositories

Description

For Women, Adults

Indications

Thrush