Ketonal cream 5%, 100g

Composition

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of 1 g contains:

Active ingredients:

ketoprofen 100 g.

Auxiliary substances:

methylparahydroxybenzoate-4 mg,

propylparahydroxybenzoate-1.0 mg,

propylene glycol-140 mg,

isopropyl myristate-100 mg,

white vaseline-640 mg,

elfacos ST9-60 mg,

propylene glycol glyceryl oleate-180 mg,

magnesium sulfate-10 mg,

purified water-765 mg

Pharmacological action

Ketonal is an NSAID derived from propionic acid. It has analgesic, anti-inflammatory and antipyretic effects. The mechanism of action is associated with inhibition of prostaglandin synthesis at the cyclooxygenase level. In addition, ketoprofen inhibits lipoxygenase, has anti-radikinin activity, stabilizes lysosomal membranes, and causes significant inhibition of neutrophil activity in patients with rheumatoid arthritis. The pronounced analgesic effect of ketoprofen is due to two mechanisms: peripheral (indirectly, through suppression of prostaglandin synthesis) and central (due to inhibition of prostaglandin synthesis in the central and peripheral nervous systems).

Indications

It is used for joint and muscle pain caused by injuries or chronic diseases, including arthritis or arthrosis. Ketonal cream with an enhanced formula begins to act in 30 minutes.

Use during pregnancy and lactation

The drug is contraindicated for use in the third trimester of pregnancy. Use in the first and second trimesters is possible in cases where the expected benefit of therapy for the mother exceeds the potential risk to the fetus. The use of Ketonal® during lactation (breastfeeding) is not recommended.

Contraindications

— hypersensitivity to the components of the drug;

— hypersensitivity to salicylates, tiaprofenic acid or other NSAIDs, the fenofibrate, blockers of UV rays, the fragrance-free;

— violation of the integrity of the skin (eczema, weeping eczema, open or infected wound);

— specifying a history of asthma attacks caused by NSAIDs and salicylates;

— of photosensitivity reactions in the anamnesis;

— exposure to sunlight, including indirect sunlight and UV radiation in a tanning bed for the entire period of treatment and 2 weeks after cessation of treatment;

III trimester of pregnancy;

— children’s age up to 15 years.

With caution:  impaired liver and/or kidney function, erosive and ulcerative lesions of the gastrointestinal tract, blood diseases, bronchial asthma, chronic heart failure.

Interaction

Concomitant use of other topical dosage forms containing ketoprofen or other NSAIDs is not recommended. With simultaneous use of acetylsalicylic acid and ketoprofen, the binding of ketoprofen to plasma proteins decreases.

How to take, course of use and dosage

Adults and children over the age of 15 years Ketonal cream is applied to the skin of the affected area in a thin layer 2 times a day (gel-1-2 times) and gently rub it. The amount of cream, gel depends on the size of the affected area (5 cm of gel corresponds to 100 mg of ketoprofen,10 cm-200 mg of ketoprofen). It is not recommended to use an occlusive dressing. The duration of treatment is 7-10 days. After applying the gel, cream, you should wash your hands. Ketonal cream or gel can be used in combination with other dosage forms (capsules, tablets, suppositories). The total maximum daily dose should not exceed 200 mg of ketoprofen, regardless of the dosage form.

Overdose

Symptoms:  irritation, erythema, pruritus.

Treatment:  you should stop using the drug. The patient should consult a doctor.

Special instructions

Ketonal cream should not be applied to the mucous membranes, anal or genital area, as well as on large areas of the skin, under occlusive dressings, on the skin around the eyes. Do not allow the cream or gel to get into the eyes. Do not exceed the recommended dosage and apply the cream, gel together with other topical products on the same skin areas. Use during pregnancy and lactation The use of the drug is contraindicated in the third trimester of pregnancy, in the first and second trimester, the use of cream, gel is possible only as prescribed by a doctor if the expected benefit to the mother exceeds the potential risk to the fetus. Breast-feeding should be discontinued during ketoprofen treatment. Children. The drug is not used in children over the age of 15 years. Ability to influence the reaction rate when driving vehicles or working with other mechanisms. There are no data on the effect of Ketonal cream and gel on the ability to drive a car and mechanisms.

Form of production

Cream for external use 5% white or almost white color, uniform.

Active ingredient

Ketoprofen