Ketosteril pills 50mg, 100pcs

Composition

Active ingredients:

DL-methyl-oxo-2-calcium valerinate (a-ketoanalog of isoleucine) 67 mg,

Methyl-4-oxo-2-calcium valerinate (a-keto analog of leucine) 101 mg,

Oxo-2-phenyl-3-calcium propionate (a-keto analog of phenylalanine) 68 mg,

Methyl-oxo-2-calcium butyrate (a-ketoanalogue valine) 86 mg,

DL-hydroxy-2-calcium methylbutyrate (a-hydroxyanisol methionine) 59 mg,

L-lysine monoacetate 105 mg,

L-threonine 53 mg,

L-tryptophan 23 mg,

L-histidine 38 mg,

L-tyrosine 30 mg;

Auxiliary substances:

corn starch,

polyvinylpyrrolidone,

talc,

colloidal silicon dioxide,

magnesium stearate,

polyethylene glycol 6000,

polyvinylpyrrolidone soluble;

Shell:

talc,

polyethylene glycol 6000,

quinoline yellow (E 104),

eudragite E 125,

triacetin,

titanium dioxide.

Pharmacological action

Ketosteril is a combination drug.

It is a source of essential amino acids with minimal introduction of nitrogen. Ketone analogs of amino acids in the body are enzymatically transaminated to the corresponding L-amino acids, thus breaking down urea.

The drug promotes the utilization of nitrogen-containing metabolic products, anabolism of proteins while reducing the concentration of urea in the serum. Improves nitrogen metabolism. Reduces the concentration of potassium, magnesium and phosphate ions in the blood.

With the systematic use of the drug, there was an improvement in the condition of patients with chronic renal failure. In some cases, it is possible to delay the start of dialysis.

Indications

Protein and energy deficiency, prevention and treatment of disorders in adults and children over 3 years of age caused by altered protein metabolism in chronic renal failure and protein restriction in the diet.

It is mainly used in patients with chronic renal failure with a glomerular filtration rate below 25 ml / min, which does not exclude the use of glomerular filtration rate and above 25 ml/min.

Contraindications

• hypersensitivity;
• violation of amino acid metabolism;
• hypercalcemia.

With hereditary phenylketonuria, it should be taken into account that the drug contains phenylalanine.

Side effects

In some cases, hypercalcemia may develop.

At the same time, it is recommended to reduce the intake of vitamin D. If hypercalcemia persists, reduce the dose of Ketosteril®, as well as other sources of calcium.

Interaction

With the simultaneous use of drugs containing calcium, it is possible to increase the level of calcium in the blood serum.

As uremic symptoms decrease under the influence of Ketosteril, the dose of aluminum hydroxide used simultaneously should be reduced accordingly.

In order not to interfere with intestinal absorption, do not take concomitantly with Ketosteril preparations that form hardly soluble compounds with calcium (for example, tetracyclines, quinolones, preparations containing iron, fluorine and estramustine ).

There should be an interval of at least 2 hours between taking Ketosteril and similar medications.

How to take, course of use and dosage

Inside, while eating, without chewing. Adults and children from 3 years — 1 tablet 5 kg / day or 0.1 g / kg/day. Unless otherwise prescribed, take 3 times a day.

Duration of use: Ketosteril® is prescribed for the entire period when the glomerular filtration rate is below 25 ml / min. During the predialysis period, it is recommended that the protein content in food should not exceed 40 g per day (depending on the degree of chronic renal failure). In dialysis patients, protein intake should meet accepted standards.

The usual dose for an adult (body weight 70 kg) is 4-8 tablets 3 times a day. The usual dose for children is 1 tablet/5 kg / day.

The recommended protein content in food for children from 3 to 10 years is 1.4-0.8 g / kg / day, from 10 years-1-0.6 g/kg/day.

Special instructions

Use in patients with impaired renal function: Ketosteril is used during the entire period when the glomerular filtration rate is less than 25 ml / min.

In case of hypercalcemia, it is recommended to reduce the dose of vitamin D. If hypercalcemia persists, reduce the dose of Ketosteril, as well as other sources of calcium.

It is necessary to regularly monitor the calcium content and monitor the decrease in serum phosphate levels.

Ketosteril should be taken with a meal to improve its absorption and conversion to the appropriate amino acids. It is necessary to provide sufficient caloric content of food.

Form of production

Coated tablets

Storage conditions

Store in a dry place, protected from light, at a temperature not exceeding 25 °C

Shelf life

3 years

Active ingredient

Ketoanalogs of amino acids

Conditions of release from pharmacies

By prescription

Dosage form

Tablets