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Cresemba: What is it and How Does it Work?

Cresemba, also known as isavuconazonium sulfate, is an antifungal medication used to treat adults and children with severe fungal infections. It is a powerful weapon against two deadly fungal illnesses: mucormycosis and invasive aspergillosis.

Cresemba is available in two forms: lyophilized for injection and capsules for oral use.

Cresemba’s Composition

Each vial of Cresemba lyophilizate contains 200 mg of isavuconazole, delivered as 372.6 mg of isavuconazonium sulfate. Isavuconazonium sulfate is a prodrug of isavuconazole, meaning it transforms into the active antifungal agent once it enters the body.

Advantages and Results of Cresemba

Cresemba is a potent antifungal drug that helps combat major fungal infections. It works by stopping the spread of fungus, allowing the body to fight the infection.

Cresemba’s Intended Use

Cresemba is used to treat adults and children suffering from either of two life-threatening fungal infections: invasive aspergillosis and mucormycosis.

Invasive Aspergillosis

Aspergillus is a common mold found in the environment. When Aspergillus enters the body and causes an infection, it is known as invasive aspergillosis. This infection can be fatal if left untreated and can damage the lungs, sinuses, and brain.

Mucormycosis

Mucormycosis is a rare but dangerous fungal infection caused by a genus of molds called mucormycetes. It can affect the sinuses, brain, lungs, and skin. People with compromised immune systems or certain medical conditions like diabetes are particularly susceptible to mucormycosis.

Cresemba Use

Whether Cresemba is administered orally (by mouth) or intravenously (by injection) depends on the specific infection and the patients health condition. Your doctor will determine the optimal dosage and administration method for your individual needs.

Cresemba Dosage and Administration

The dosage of Cresemba varies based on the type of fungal infection being treated, the patients weight and age, and other individual factors.

Adults

• Loading Dose: 372 mg of isavuconazonium sulfate (equal to 200 mg of isavuconazole) every 8 hours for a total of 6 doses (48 hours). This loading dose can be administered orally or intravenously.
• Maintenance Dose: 200 mg of isavuconazole (equal to 372 mg of isavuconazonium sulfate) once daily. This can be administered either intravenously or orally.

Adults with Mucormycosis

• Loading Dose: 372 mg of isavuconazonium sulfate (equal to 200 mg of isavuconazole) given every 8 hours for a total of 6 doses (48 hours). This loading dose can be administered orally or intravenously.
• Maintenance Dose: 200 mg of isavuconazole (equal to 372 mg of isavuconazonium sulfate) once daily. This can be administered either intravenously or orally.

Side Effects of Cresemba

Like all medications, Cresemba has side effects. Common side effects include nausea, vomiting, diarrhea, headaches, and increased liver enzymes. Potential serious adverse effects include renal, heart, and liver damage. It is important to discuss any adverse effects you experience while using Cresemba with your doctor.

Contraindications of Cresemba

Cresemba is not suitable for everyone. You should not take Cresemba if you have an allergy to isavuconazole or any of the ingredients in Cresemba. Inform your doctor about all other medications you are taking, including vitamins, herbal supplements, over-the-counter drugs, and Cresemba, as they may interact with each other.

Storage Conditions for Cresemba

Store Cresemba lyophilizate vials refrigerated between 2 and 8 degrees Celsius (36°F and 46°F). Once reconstituted, use the solution immediately or store it between 5°C and 25°C (41°F and 77°F) for up to one hour before preparing the patient infusion solution.

Purchase Cresemba at Medixlife

Cresemba is among the premium medications you can find at Medixlife. We are dedicated to providing our customers with the best possible service and support. Order your Cresemba now to experience the Medixlife difference.

Cresemba Lyophilizate: Medixlife Confidence Fights Fungal Infections