Composition
of 1 g: – Hydrocortisone butyrate 1 mgm Auxiliary substances: white vaseline-up to 1 g
Pharmacological action
Laticort is a synthetic non-halogenated corticosteroid for external use. It has a rapid anti-inflammatory, decongestant, antipruritic and anti-allergic effect. Due to the local vasoconstrictor effect, it reduces exudative reactions.
The use of Laticort in the recommended doses does not cause suppression of the hypothalamic-pituitary-adrenal system.
Pharmacokinetics
Absorption After application of Laticort, the Active ingredient accumulates in the epidermis, mainly in the granular layer.
Metabolism Hydrocortisone butyrate absorbed through the skin is metabolized to hydrocortisone and other metabolites directly in the epidermis and subsequently in the liver.
Excretionmetabolites and a small portion of unchanged hydrocortisone butyrate is excreted by the kidneys and bile.
Indications
Uninfected, sensitive to local corticosteroids skin diseases that occur with excessive keratinization:
- atopic dermatitis;
- seborrheic dermatitis;
- contact eczema;
- psoriasis;
- lichen planus.
- erythroderma;
Insect bites.
Use during pregnancy and lactation
The use of Laticort® in pregnant women is allowed in cases where, according to the attending physician, the potential benefit to the pregnant woman prevails over the possible risk to the fetus.
In these cases, the application should be short and limited to small areas of the skin. It is not recommended to use in the first trimester of pregnancy.
During breastfeeding, it should be applied briefly on a small surface of the skin and not applied on the skin of the breast.
Contraindications
- bacterial, viral and fungal infections of the skin;
- perioral dermatitis;
- the violation of the integrity of the skin (wounds, ulcers);
- acne vulgaris, acne rosacea;
- skin tumors;
- tubercular or syphilitic lesions of the skin;
- postvaccinal period;
- children up to age 6 months, with itching in the anus area – up to 12 years;
- hypersensitivity to the components of the drug Laticort.
With caution, the drug should be prescribed for diabetes mellitus, tuberculosis (systemic damage).
Side effects
Side effects are rare and reversible.
Local reactions: rarely-skin irritation.
With prolonged use and/or application of Laticort on large surfaces, when using occlusive dressings in rare cases, acne-like changes, hypopigmentation, sweating, folliculitis, striae, skin atrophy, hypertrichosis and secondary skin infections are possible.
In rare cases, allergic contact dermatitis may develop.
Interaction
There are no data on the drug interaction of Laticort® with other drugs.
How to take, course of use and dosage
Apply externally.
In adults, a small amount of Laticort is applied to the affected skin 1-3 times a day. The course of treatment is 1-3 weeks. The dose of the drug used during the week should not exceed 30-60 g. To improve penetration, the drug is applied with massaging movements. In cases of a resistant course of diseases, for example, with the localization of dense psoriatic plaques on the elbows, knees, the drug should be used under occlusive dressings.
In children, the drug Laticort is used from the age of 6 months.
In childhood, suppression of the adrenal cortex may develop faster. In addition, there may be a decrease in the excretion of growth hormone. When using the drug for a long time, it is necessary to monitor body weight, height, and plasma cortisol levels. In control studies, children who received 30-60 g of Laticort® ointment weekly were not found to have impaired adrenal cortex function.
When using Laticort on the face or under occlusive dressings (diapers, diapers), a high degree of absorption is possible, so it is recommended to apply a minimum dose of the drug. Treatment should be carried out briefly and under the supervision of a doctor.
Overdose
There are no data on overdose of Laticort®. With prolonged use of the drug in large doses, symptoms of hypercorticism may occur.
Treatment: carry out symptomatic therapy against the background of gradual withdrawal of the drug.
Special instructions
Avoid contact with Laticort® in the eyes.
If a secondary bacterial or fungal infection develops, an external antibacterial or antifungal agent should be prescribed.
With extreme caution, the drug should be used on the skin of the face due to the possibility of side effects (telangiectasia, atrophy, perioral dermatitis).
If after 7 days of use there is no improvement or deterioration of the condition, as well as if symptoms resume several days after discontinuation, the drug should be discontinued and a doctor should be consulted. Although the use of the drug in high doses for a long time, especially when using occlusive dressings, can lead to an increase in the content of cortisol in blood plasma, this is never accompanied by a decrease in the reactivity of the pituitary-adrenal system, and the withdrawal of the drug leads to a rapid normalization of cortisol production.
Use the drug with caution in cases of pre-existing atrophic skin conditions, especially in the elderly. The risk of side effects when using Laticort® is lower than when using halogenated corticosteroids.
Laticort ® ointment is recommended for use in subacute inflammatory conditions and lichenification.
Influence on the ability to drive motor vehicles and manage mechanisms
The use of the drug does not limit the psychophysical abilities of the patient, the ability to drive vehicles and maintain machinery in motion.
Form of production
Ointment for external use.
Active ingredient
Hydrocortisone
Dosage form
ointment
Description
For children as prescribed by a doctor, For adults
Indications
Eczema, Psoriasis, Dermatitis
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Side effects of Laticort, ointment 0.1%, 15g.
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