Legalon 70, capsules 70mg, 60pcs

Product description

Pharmacotherapeutic group: hepatoprotective agent. ATX code: A 05 VA 03.

Composition

One capsule contains: Active ingredient: milk thistle Spotted Fruit Extract Dry (36-44: 1) – 86.5-93.35 mg, equivalent to 70 mg of silymarin (DNPH), equivalent to 54.1 mg of silymarin (HPLC/Germ. F. ) based on silibinin. Excipients: polysorbate 80, povidone, mannitol, sodium carboxymethyl starch (type A), magnesium stearate. Shell: solid gelatin capsule, size “2”, which includes: gelatin, iron oxide red dye (E 172), titanium dioxide (E 171), sodium lauryl sulfate, iron oxide black dye (E 172).

Pharmacological action

It interacts with free radicals in the liver and converts them into less toxic compounds, interrupting the process of lipid peroxidation, and prevents the destruction of cellular structures. In damaged hepatocytes, it stimulates the synthesis of structural and functional proteins and phospholipids (due to specific stimulation of RNA polymerase A), stabilizes cell membranes, prevents the loss of cell components (transaminases), and accelerates the regeneration of liver cells. Inhibits the penetration of certain hepatotoxic substances into the cell.

Pharmacokinetics.

Absorption is low and slow (the half-absorption period is 2.2 hours), it is metabolized in the liver by conjugation, the half-life is 6 hours. It is mainly excreted in the bile in the form of glucuronides and sulfates. It does not accumulate in the body. Intestinal-hepatic circulation is noted.

Indications

Toxic liver damage (alcoholism, intoxication with halogen-containing hydrocarbons, heavy metal compounds, medicinal liver damage) and their prevention.

Use during pregnancy and lactation

It is not recommended to use the drug during pregnancy and lactation

Recommendations for use

Inside, after eating, with a small amount of water

Contraindications

Hypersensitivity to the components of the drug.

Side effects

Allergic reactions, rarely-laxative effect.

How to take, course of use and dosage

Take 2 capsules 3 times a day. Maintenance dose-1 capsule 3 times a day.

Description

Capsule appearance: solid gelatin capsules, size “2”, brown body and lid. Appearance of the capsule contents: yellow powder.

Form of production

Capsules

Storage conditions

In a place protected from light, at a temperature not exceeding 30 ° C. Keep out of reach of children.

Shelf

life is 5 years. Do not use after the expiration date indicated on the package.

Active ingredient

Milk Thistle Spotted Fruit Extract

Dosage form

Capsules