Composition
Active ingredient:
Chloramphenicol – 1 g
Auxiliary substances:
ethyl alcohol 70%
Pharmacological action
The Active ingredient of the drug is chloramphenicol-a broad-spectrum antibiotic with high antibacterial activity against the causative agent of wound infection and various forms of purulent-inflammatory processes.
Chloramphenicol is a bacteriostatic antibiotic that disrupts the process of protein synthesis in a microbial cell (with good lipophilicity, it penetrates the bacterial cell membrane and binds back to the 5OS subunit of bacterial ribosomes, in which the movement of amino acids to growing peptide chains is delayed, which leads to a violation of protein synthesis).
Active against most strains of gram-positive and gram-negative microorganisms resistant to penicillin, tetracyclines, and sulfonamides. Promotes cleansing and healing of burn wounds and trophic ulcers, accelerates epithelialization.
Indications
Bacterial skin infections caused by sensitive microorganisms, including infected burns (superficial and delineated deep), bedsores, trophic ulcers, wounds, boils.
Contraindications
Increased individual sensitivity to the components of the drug.
The drug is not prescribed to patients suffering from glucose-6-phosphate dehydrogenase deficiency, severe renal and / or hepatic dysfunction, intermittent porphyria and impaired hematopoietic system function.
The drug should not be prescribed to patients with skin diseases, including diseases of fungal etiology, psoriasis and eczema.
The drug is not used for the treatment of women during pregnancy and lactation, as well as for the treatment of children under the age of 1 year.
The drug should be used with caution in patients who have received radiation therapy, as well as cytostatic therapy.
Side effects
from the hematopoietic system: Â thrombocytopenia, leukopenia, agranulocytosis, aplastic anemia.
From the digestive system: Â nausea, vomiting, diarrhea, flatulence.
From the central nervous system and peripheral nervous system: Â peripheral neuritis, optic neuritis, headache, depression, confusion, delirium, visual and auditory hallucinations.
Allergic reactions: Â skin rash, urticaria, angioedema.
Local reactions: Â irritant effect (with external or topical application).
Interaction
No special features.
How to take, course of use and dosage
The drug is intended for external use.
Adults and children over the age of 1 year with bacterial infections of the skin, as well as damage to the integrity of the skin, are usually prescribed to apply the solution to the damaged area 2-3 times a day. The solution should be applied to a cotton swab, which is then used to treat the skin.
Adults and children over the age of 1 year with purulent otitis media are usually prescribed 2-3 drops of the solution 1-2 times a day. The solution should be pipetted into the external ear canal. In the presence of strong secretions, the drug can be used 3-4 times a day.
In severe forms of infectious diseases of the skin and ear, the drug is usually prescribed in combination with systemic antimicrobials.
The duration of the course of treatment is determined by the attending physician individually.
Overdose
With prolonged use, as well as with the use of high doses of the drug, patients may develop irritation of the skin and mucous membranes, as well as local allergic reactions, including skin rash, itching and urticaria. In isolated cases, the development of edema and hyperemia at the site of high doses of the drug was noted.
If symptoms of overdose develop, the dose of the drug should be reduced, if the patient does not improve after reducing the dose, the drug is discontinued.
Special instructions
Chloramphenicol is not used in newborns, because it is possible to develop a “gray syndrome” (flatulence, nausea, hypothermia, gray-blue skin color, progressive cyanosis, dyspnea, cardiovascular failure).
Use with caution in patients who have previously received treatment with cytostatic drugs or radiation therapy.
When taking alcohol at the same time, a disulfiram-like reaction may develop (hyperemia of the skin, tachycardia, nausea, vomiting, reflex cough, convulsions).
In the course of treatment, systematic monitoring of the peripheral blood picture is necessary.
Form of production
Solution for external use (alcohol).
Storage conditions
In a dark place, at a temperature not exceeding 25 °C.
Shelf life
2 years
Active ingredient
Chloramphenicol
Dosage form
solution for external use
Description
Children as prescribed by a doctor, Children older than 1 month, For adults
Indications
From boils, From trophic ulcers, From pressure sores, From skin infections, Burns
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