Libexin pills 100mg, 20pcs

Composition

Active ingredient:

prenoxdiazine hydrochloride 100 mg;

Auxiliary substances:

glycerol (glycerin);

magnesium stearate;

talc;

povidone;

corn starch;

lactose monohydrate.

Pharmacological action

Prenoxdiazine is a peripheral antitussive agent.

The drug Libexin blocks the peripheral links of the cough reflex due to the following effects: :

— local anesthetic action, which reduces the irritability of the peripheral sensitive (cough) receptors of the respiratory tract;

– bronchodilator action, which suppresses the stretch receptors involved in the cough reflex;

– a slight decrease in the activity of the respiratory center (without respiratory depression). The antitussive effect of the drug is approximately equal to that of codeine.

Prenoxdiazine is not addictive or drug-dependent. In chronic bronchitis, the anti-inflammatory effect of prenoxdiazine was noted. Prenoxdiazine does not affect the function of the central nervous system, except for a possible indirect anxiolytic effect.

Indications

Unproductive cough of any origin:

• catarrh of the upper respiratory tract, influenza, acute and chronic bronchitis, pneumonia, emphysema;
• night cough in patients with heart failure;
• preparation of patients for bronchoscopic or bronchographic examination.

Contraindications

• hypersensitivity to the drug;
• diseases associated with abundant bronchial secretion;
• condition after inhalation anesthesia;
• galactose intolerance, lactase deficiency or glucose-galactose malabsorption.

With caution:  children’s age.

Side effects

Allergic reactions:  rarely-skin rash; angioedema; unknown frequency-bronchospasm.

From the gastrointestinal tract:  rarely-dry mouth or throat; anesthesia (temporary numbness and loss of sensation) of the oral mucosa; often-stomach pain; constipation; nausea.

Nervous system disorders (when using the drug in high doses):  unknown frequency-mild sedation; fatigue.

Interaction

It is not recommended to combine the drug with mucolytic and expectorant agents, because it can make it difficult to release sputum, which is diluted by the latter.

There are no preclinical or clinical data on interactions with other drugs.

How to take, course of use and dosage

Inside. Tablets are swallowed without chewing (to avoid anesthesia of the oral mucosa).

The average adult dose is 100 mg 3 or 4 times a day (1 tablet 3-4 times a day). In more complex cases, the dose can be increased to 200 mg 3-4 times or 300 mg 3 times a day (2 tablets 3-4 times a day or 3 tablets 3 times a day).

The average dose for children, depending on age and body weight, is 25-50 mg 3 or 4 times a day (1/4-1/2 tablets 3-4 times a day).

The maximum single dose for children is 50 mg (1/2 tablet), for adults-300 mg (3 tablets). The maximum daily dose for children is 200 mg (2 tablets), for adults — 900 mg (9 tablets).

In preparation for bronchoscopy, a dose of 0.9–3.8 mg/kg is combined with 0.5-1 mg of atropine 1 hour before the procedure.

Special instructions

The drug may cause gastrointestinal complaints in patients with lactose intolerance, since each tablet contains 0.38 mg of lactose.

Influence on the ability to drive vehicles and perform work related to increased danger.

Taking the drug in high doses can slow down the rate of reactions, so when taking the drug in high doses, the question of whether it is possible to drive a car or engage in work related to increased danger should be decided individually.

Composition

Tablet Form of production

Storage conditions

At a temperature not exceeding 25 °C.

Shelf life

5 years

Active ingredient

Prenoxdiazine

Dosage form

Tablets