Lincomycin, 30% ampoules, 1ml, 10pcs – Dalkhimpharm

Composition

Active ingredient:

lincomycin hydrochloride 0.3 g

Pharmacological action

Lincomycin is an antibiotic of the lincosamide group. In therapeutic doses, it acts bacteriostatically, with higher doses it has a bactericidal effect. The antibacterial mechanism is based on the principle of reversible binding of lincomycin to the 50S subunit of the bacterial ribosome, which leads to disruption of protein synthesis and death of the microorganism.

The drug is active against gram-positive aerobes: Staphylococcus spp. including penicillinase-producing strains; Streptococcus spp. (including Streptococcus pneumoniae), Bacillus anthracis, Corynebacterium diphtheriae; gram-positive anaerobes: Actinomices spp., Bacteroides spp., Clostridium spp., Peptococcus spp., Peptostreptococcus spp. ; intracellular pathogens Mycoplasma spp.

It has no effect on Enterococcus faecalis, gram-negative microorganisms, fungi, viruses and protozoa. Sustainability is developing slowly.

Pharmacokinetics

When taken orally, lincomycin hydrochloride is rapidly absorbed from the digestive tract if taken on an empty stomach. Bioavailability is 20-40% of the dose taken. The drug is distributed throughout the body, penetrates most fluids and tissues (liver, kidneys, myocardium, lungs, including bone tissue, where it accumulates in relatively high concentrations). It penetrates the blood-brain barrier in a small amount, but the permeability increases with meningitis. It also penetrates through the placenta and is excreted in the mother’s milk. It is partially metabolized in the liver to inactive metabolites. Protein binding decreases with an increase in the concentration of the drug in blood plasma and, on average, is 70-76%.

The elimination half-life in patients with normal liver and kidney function is 4-6 hours, in patients with end-stage renal insufficiency it is 10-20 hours. After a single oral dose of the drug, the maximum concentration in blood plasma is reached in 2-4 hours.

It is excreted unchanged and in the form of metabolites in the urine, bile and feces (approximately 30-40% of the oral dose is excreted in the feces in 72 hours).

Indications

Lincomycin is prescribed for infectious and inflammatory diseases caused by microorganisms sensitive to the drug:  

• infections of bones and joints (osteomyelitis, septic arthritis);
• upper and lower respiratory tract infections, otitis media, sinusitis;
• purulent infections of the skin and soft tissues (boils, abscesses, infected wounds, panaritia, mastitis), erysipelas;
• as a reserve antibiotic for infections caused by microorganisms resistant to penicillin and other antibiotics.

Contraindications

Hypersensitivity, hepatic-renal failure, pregnancy.

Side effects

Dizziness, weakness, skeletal muscle relaxation, hypotension, leukopenia, thrombocytopenia.

Interaction

It is not recommended to use Lincomycin simultaneously with:  

• narcotic analgesics, since respiratory failure is possible up to apnea;
• means that slow down the peristalsis of the gastrointestinal tract;
• inhaled anesthetics, muscle relaxants; 
• cholestyramine, kaolin, vikair, vikalin and other drugs that have adsorbing properties (they reduce the absorption of Lincomycin);
• pyridostigmine, neostigmine, ambenonium, as their effect is weakened; 
• levomycetin, erythromycin (weaken the antibacterial effect of Lincomycin);
• with clindamycin, doxorubicin, as there are cases of cross-hypersensitivity.

How to take, course of use and dosage

Intramuscularly, adults 0.5 g 2 times a day, in severe cases-0.5 g 3 times a day; children-a daily dose of 15-30 mg / kg in 2 injections. IV drip (60-80 drops / min) 0,6 g 3 times a day. The course lasts 7-14 days, in some cases-up to 1 month.

Overdose

With long-term treatment, pseudomembranous colitis, candidiasis are possible.

Treatment:  If pseudomembranous colitis develops, Lincomycin should be discontinued.

Product form

solution for injection

Storage conditions

In a dark place, at a temperature of 5-25 °C.

Shelf life

3 years

Active ingredient

Lincomycin

Conditions of release from pharmacies

By prescription

Dosage form

solution for injection and infusion