Livarole, vaginal suppositories 400mg, 5pcs

Composition

Active ingredient:  

Ketoconazole – 400 mg;

Auxiliary substances:  

Butylhydroxyanisole.

Basis for suppositories:  

Macrogol 1500 (polyethylene oxide 1500),

Macrogol 400 (polyethylene oxide 400) – a sufficient amount to obtain a suppository weighing 3.0 g

Pharmacological action

The Active ingredient is ketoconazole, a derivative of imidazoldioxolan.

It has a fungicidal and fungostatic effect against dermatophytes (Trichophyton spp., Epidermophyton floccosum, Microsporum spp. ) and yeast (Candida spp., Pityrosporum spp. ).

The mechanism of action consists in inhibiting the biosynthesis of ergosterol and changing the lipid composition of the fungal membrane.

The drug is active against staphylococci and streptococci.

Pharmacokinetics

Systemic absorption with intravaginal use is insignificant.

Indications

Treatment of acute and chronic recurrent vaginal candidiasis. Prevention of the occurrence of fungal infections of the vagina with reduced resistance of the body and against the background of treatment with antibacterial agents and other drugs that violate the normal microflora of the vagina.

Contraindications

Hypersensitivity to the components of the drug. Pregnancy (I trimester).

With caution:  pregnancy (II-III trimester), lactation, children under 12 years of age.

Side effects

Hyperemia and irritation of the vaginal mucosa, itching of the vagina.

Allergic reactions: skin rash, urticaria.

Interaction

When using Livarole® vaginal suppositories 400 mg. negative interactions with other drugs are not known and should not be expected, since the resorption capacity of ketoconazole is low.

How to take, course of use and dosage

After releasing the suppository from the contour package, it is inserted deep into the vagina in the supine position for 1 suppository per day for 3-5 days, depending on the course of the disease.

For chronic candidiasis,1 suppository is used for 10 days.

Product form

vaginal suppositories

Storage conditions

Store in a dry place, protected from light, at a temperature not exceeding 25 °C

Shelf life

2 years

Active ingredient

Ketoconazole

Dosage form

vaginal suppositories

Description

Nursing mothers, Pregnant women in the second and third trimester as prescribed by a doctor, For women, Adults, Children over 12 years of age

Indications

Vaginal Candidiasis