Locoid, cream 0.1%, 30g

Composition

Cream for external use is white, homogeneous.

1 g hydrocortisone butyrate 1 mg

Auxiliary substances:

cetostearyl alcohol 72 mg,

macrogol 25 cetostearyl ether 18 mg,

liquid paraffin 60 mg,

soft white paraffin 150 mg,

propyl parahydroxybenzoate 1 mg,

butyl parahydroxybenzoate 0.5 mg,

citric acid anhydrous 4.2 mg,

sodium citrate anhydrous 2.8 mg,

purified water up to 1 g

Pharmacological action

Locoid is a synthetic non-halogenated glucocorticosteroid for external use.

Esterification of the hydrocortisone molecule with butyric acid residue (butyrate) allowed a radical increase in the activity of the drug compared to native hydrocortisone.

Locoid has a rapidly advancing anti-inflammatory, decongestant, antipruritic effect. The use of Locoid in the recommended doses does not cause suppression of the hypothalamic-pituitary-adrenal system.

Although the use of high doses of the drug for a long time, especially when using occlusive dressings, can lead to an increase in the content of cortisol in blood plasma, this is usually not accompanied by a decrease in the reactivity of the pituitary-adrenal system, and the withdrawal of the drug leads to a rapid normalization of cortisol production.

Pharmacokinetics:  

After application, the Active ingredient accumulates in the epidermis, mainly in the granular layer, and systemic absorption is insignificant. A small amount of hydrocortisone 17-butyrate is absorbed into the systemic circulation unchanged.

Most of hydrocortisone 17-butyrate is metabolized to hydrocortisone and other metabolites directly in the epidermis and subsequently in the liver.

Metabolites and a small portion of unchanged hydrocortisone 17-butyrate are excreted by the kidneys and through the intestines.

Indications

Superficial, uninfected, topical corticosteroid-sensitive skin diseases: – dermatitis, including atopic, contact, seborrheic; – eczema;- psoriasis.

Contraindications

-hypersensitivity to hydrocortisone or auxiliary components of the drug;— bacterial skin infections (streptoderma and staphyloderma, gram-negative folliculitis, etc. ); – viral skin infections (herpes simplex, chickenpox, shingles, etc. )— – fungal skin infections;- tuberculosis and syphilitic skin lesions;— parasitic skin infections— – neoplastic skin changes (benign and malignant tumors);- acne, rosacea, perioral dermatitis;— post-vaccination period;- violation of the integrity of the skin (wounds, ulcers). With caution: pregnancy, lactation.

Side effects

Local reactions: skin irritation, in rare cases-other local reactions characteristic of external steroid therapy.

Systemic reactions: with prolonged use, application to large surfaces and / or occlusion, side effects characteristic of systemic glucocorticosteroids may occur.

The risk of local and systemic side effects with Locoid is lower than with fluoridated steroids.

How to take, course of use and dosage

Externally.

Locoid cream is preferably used for acute and subacute skin processes (without wetting).

The drug is applied to the affected areas of the skin in a thin layer 1-3 times a day. To improve penetration, the drug is applied with light massaging movements. If there is a positive trend, the frequency of use of the drug can be reduced to 2-3 times a week.

The dose of the drug used during the week should not exceed 30-60 g.

Overdose

There are no data on an overdose of Locoid.

With prolonged use of the drug in high doses, it is possible to increase the side effects described above.

If symptoms of hypercorticism occur, the drug should be discontinued.

Special instructions

It can be used in children from 6 months of age. If the drug is used in children, on the face area or under occlusive dressings, the duration of treatment should be reduced.

When used in children, the surface area of the skin on which the drug is applied should not exceed 20% of the total. In childhood, suppression of the adrenal cortex can develop faster. In addition, there may be a decrease in the excretion of growth hormone. When using the drug for a long time, it is necessary to monitor body weight, height, and plasma cortisol levels. In a study in children who received 30-60 g of Locoid per week for 4 weeks in comparison with 1% hydrocortisone ointment, no child was found to have impaired adrenal cortex function, while no differences between hydrocortisone 17-butyrate in this indicator and conventional hydrocortisone were observed.

Do not apply Locoid to the periorbital area due to the risk of glaucoma. If the conjunctiva is systematically exposed, there is a risk of increased intraocular pressure.

When the process is localized on the scalp and with exudative inflammation, it is preferable to use a Locoid in the form of Crelo.

In cases of a resistant course of diseases, for example, with the localization of dense psoriatic plaques on the elbow areas, knees, pronounced lichenification, dryness, it is better to give preference to Locoid in the form of ointment or Lipocrem, if necessary – under occlusive dressings.

The drug should not be used in the presence of atrophic skin changes. The risk of local and systemic side effects increases when applied to large areas of the lesion, prolonged use, use of occlusion and in childhood.

If there is no effect during 2 weeks of continuous treatment, the diagnosis should be clarified.

As with any glucocorticoid preparation, it is advisable to limit the duration of use and the course dose to the minimum sufficient to stop the skin process.

Influence on the ability to drive vehicles and work with mechanisms:

There are no data on the effect of Locoid on the ability to drive vehicles and work with mechanisms.

Product form

Cream.

Storage conditions

At a temperature of 15-25 °C, in a well-sealed container

Shelf life

5 years

Active ingredient

Hydrocortisone

Dosage form

cream

Description

For adults, Children over 6 months of age

Indications

Allergies, Insect Bites, Seborrhea, Eczema, Psoriasis, Dermatitis