Logimax, pills, 30pcs

Composition

Active ingredients:

felodipine 5 mg;

metoprolol succinate (50 mg metoprolol tartrate) 47.5 mg;

Auxiliary substances:

ethylcellulose;

hydroxypropylmethylcellulose;

hydroxypropylcellulose;

lactose anhydrous;

polyoxyl 40 hydrogenated castor oil;

MCC;

paraffin;

polyethylene glycol;

propyl gallate;

silicon dioxide;

sodium aluminum silicate;

sodium stearyl fumarate;

titanium dioxide (E171);

iron oxides (E172).

Pharmacological action

Logimax is hypotensive.

Blocks beta_-1-adrenergic receptors of the myocardium (metoprolol) and inhibits the entry of calcium ions into vascular smooth muscle cells (felodipine).

Pharmacodynamics

Metoprolol reduces the stimulating effect of catecholamines on the myocardium, cardiac output, and blood pressure.

Felodipine relaxes smooth muscles of the vascular wall, reduces OPSS, and potentiates (mutually) metoprolol-induced hypotension.

Pharmacokinetics

It is completely absorbed from the gastrointestinal tract. Systemic bioavailability of felodipine is 15%, metoprolol-50%. The plasma protein binding of felodipine is 99%. T_1/2of felodipine — 25 hours, metoprolol — 3-5 hours. Active substances are metabolized in the liver. 70% of felodipine is excreted as metabolites in the urine, while the rest is excreted in the faeces. Less than 5% of metoprolol is excreted unchanged by the kidneys.

Indications

Hypertension, symptomatic arterial hypertension.

Use during pregnancy and lactation

Contraindicated in pregnancy.

Breast-feeding should be discontinued for the duration of treatment.

Contraindications

Hypersensitivity, acute myocardial infarction, unstable angina, severe sinus bradycardia, grade II-III AV block, sinus node weakness syndrome, severe peripheral circulatory disorders, decompensated heart failure, cardiogenic shock, pregnancy.

Side effects

Nervous system and sensory disorders:  headache, weakness; dizziness, paresthesia, depression, loss of concentration, drowsiness or insomnia; nervousness, anxiety, visual disturbances, dry or irritated eyes, conjunctivitis; amnesia, confusion, hallucinations, tinnitus, impaired taste sensations.

Cardiovascular and blood disorders (hematopoiesis, hemostasis):  redness of the face, bradycardia, palpitation, postural disorders, cold extremities, peripheral edema; tachycardia, AV block I degree, pain in the heart; syncope; gangrene in patients with severe peripheral circulatory disorders, thrombocytopenia.

Respiratory system disorders:  shortness of breath with physical exertion; rhinitis.

From the digestive tract:  nausea, abdominal pain, diarrhea or constipation; vomiting, weight loss; dry mouth, changes in liver function tests; mucosal hyperplasia, increased concentration of liver enzymes.

From the genitourinary system:  impotence, sexual dysfunction.

From the musculoskeletal system:  myalgia, arthralgia.

From the side of the skin:  rash (in the form of urticaria psoriasiform), dystrophic skin lesions; hair loss; photosensitization.

Allergic reactions:  angioedema.

Interaction

Calcium channel blockers such as verapamil potentiate the negative ino-and chronotropic effects.

Increases the negative ino-and dromotropic effect of antiarrhythmic drugs (quinidine analogues, amiodarone), cardiodepressive-inhaled anesthetics.

Increase the concentration of metoprolol in plasma cimetidine, hydralazine, alcohol, lowers-rifampicin.

Indometacin and other prostaglandin synthetase inhibitors weaken the hypotensive effect.

How to take, course of use and dosage

Inside, in the morning, without chewing, with water. The initial dose is 1 tablet 1 time a day, if necessary, the dose is doubled.

There is no need to adjust the treatment regimen in patients with impaired renal function. Usually, there is no need to adjust the treatment regimen in patients with impaired liver function, including patients with cirrhosis of the liver.

If there are symptoms of serious liver dysfunction (for example, in patients with a history of bypass surgery), the possibility of reducing the dose of the drug should be considered.

In elderly patients,1 tablet is usually sufficient 1 time a day, if necessary-2 times a day.

Overdose

Symptoms:  hypotension, sinus bradycardia, AV block, heart failure, cardiogenic shock, cardiac arrest, bronchospasm, nausea, vomiting, cyanosis. The first signs appear in 20 minutes-2 hours after use.

Treatment:  induction of vomiting, gastric lavage; symptomatic treatment: in case of severe hypotension, bradycardia, or threat of heart failure — beta₁-agonist (V/V, with an interval of 2-5 minutes or infusion), or dopamine (in/in) or atropine sulfate the purpose of the blockade of the vagus nerve; dobutamine, norepinephrine, glucagon (1-10 mg). If necessary, use a heart rate monitor. For relief of bronchospasm — intravenous use of beta_-2-agonist.

Composition

Tablet Form of production

Storage conditions

At a temperature not exceeding 30 °C

Shelf life

3 years

Active ingredient

Metoprolol, Felodipine

Conditions of release from pharmacies

By prescription

Dosage form

Tablets

Description

For adults as directed by your doctor

Indications

Hypertension