Longidaza suppositories vaginal and rectal 3000IU, 10pcs

Composition

1 suppository contains:

Active ingredient:

hyaluronidase conjugate with copolymer of 1,1,4-ethylene piperazine oxide

and (N-carboxymethyl) 1,4-ethylene piperazinium bromide 3000 IU;

Auxiliary substance:

cocoa butter — until receiving a suppository weighing 1.3 g

Pharmacological action

Longidase – an enzyme, proteolytic.

Pharmacodynamics

Longidase ® has long-acting hyaluronidase (enzymatic proteolytic) activity, chelating, antioxidant, immunomodulatory and moderately pronounced anti-inflammatory properties.

Prolongation of the enzyme’s action is achieved by its covalent binding to a physiologically active high-molecular carrier (an activated derivative of poly-1,4-ethylene piperazine N-oxide, an analog of polyoxidonium), which has its own pharmacological activity. Longidase® exhibits antifibrotic properties, weakens the course of the acute phase of inflammation, regulates (increases or decreases depending on the initial level) the synthesis of inflammatory mediators (IL-1 and tumor necrosis factor-alpha), increases the humoral immune response and the body’s resistance to infection.

Pronounced antifibrotic properties of Longidase® They are provided by conjugation of hyaluronidase with the carrier, which significantly increases the resistance of the enzyme to denaturing effects and the action of inhibitors: the enzymatic activity of Longidase®is preserved when heated to 37 °C for 20 days, while native hyaluronidase under the same conditions loses its activity during the day. Longidase®provides simultaneous local presence of the proteolytic enzyme hyaluronidase and a carrier capable of binding enzyme inhibitors and stimulators of collagen synthesis released during hydrolysis of matrix components (iron, copper, heparin, etc. ). Due to these properties, Longidase® has not only the ability to depolymerize the connective tissue matrix in fibrogranulomatous formations, but also to suppress the reverse regulatory reaction aimed at the synthesis of connective tissue components fabrics.

The specific substrate of testicular hyaluronidase is glycosaminoglycans (hyaluronic acid, chondroitin, chondroitin-4-sulfate, chondroitin-6-sulfate), which form the basis of the connective tissue matrix. As a result of depolymerization (breaking the bond between C1 of acetylglucosamine and C4 of glucuronic or induronic acids), glycosaminoglycans change their basic properties: the viscosity decreases, the ability to bind water and metal ions decreases, the permeability of tissue barriers temporarily increases, the movement of fluid in the intercellular space is facilitated, the elasticity of connective tissue increases, which is manifested in a decrease in tissue edema, flattening of scars, an increase in the volume of joint movement, a decrease in contractures and prevention of their formation, a decrease in the adhesive process.

Biochemical, immunological, histological, and electron microscopic studies have proven that Longidase® it does not damage normal connective tissue, but causes the destruction of altered connective tissue in the area of fibrosis.

Longidaza® It has no mutagenic, embryotoxic, teratogenic or carcinogenic effects.

The drug is well tolerated by patients, there are no local and general allergic reactions.

The use of Longidase® in therapeutic doses during or after surgical treatment does not worsen the course of the postoperative period or the progression of the infectious process; it does not slow down the recovery of bone tissue.

Indications

• in urology:  chronic prostatitis, interstitial cystitis, urethral stricture and urethral, Peyronie’s disease, early onset benign prostatic hyperplasia, prevention of scarring and strictures after surgery on the urethra, bladder, ureters;
• in gynecology: adhesions (prevention and treatment) in the pelvis in chronic inflammatory diseases of internal genital organs after gynecological manipulations, including induced abortions migrated surgical interventions on the organs of the small pelvis: sinehii intrauterine devices, tubal-peritoneal infertility, chronic endomyometritis;
• in dermatology: limited scleroderma, prevention of fibrotic complications of infections sexually transmitted diseases;
• surgery: prevention and treatment of adhesions after surgical interventions on the abdominal organs, nonhealing wounds;
• in pneumology and Phthisiology:  pneumofibrosis, siderosis, tuberculosis (cavernous-fibrotic, infiltrative, tuberculosis), interstitial pneumonia, fibrosing alveolitis, pleurisy;
• to increase the bioavailability of antibacterial therapy in urology, gynecology, dermatovenerology, surgery, pulmonology.

Use during pregnancy and lactation

The drug is contraindicated for use during pregnancy.

Data on the safety of using the drug during lactation are not provided.

Longidase has no embryotoxic or teratogenic effects.

Contraindications

• increased individual sensitivity to drugs with hyaluronidase activity, Longidase®;
• malignant neoplasms;
• pregnancy (no clinical experience);
• children under 12 years of age (efficacy and safety have not been studied).

Use with caution (apply no more than once a week): renal failure; a history of pulmonary hemorrhage.

Side effects

Rarely-allergic reactions with increased individual sensitivity.

Interaction

When using Longidase in patients receiving salicylates, cortisone, ACTH, estrogens or antihistamines in high doses, the effectiveness of the hyaluronidase enzyme may be reduced.

When prescribed in combination with other medicinal products, the possibility of increasing their absorption (bioavailability) and enhancing the systemic effect should be taken into account.

How to take, course of use and dosage

Rectally,1 suppository 1 time a day after bowel cleansing.

Vaginally, once a day (at night),1 suppository is inserted into the vagina in the supine position.

Longidase ® suppositories 3000IU is recommended for a course of 10 to 20 injections.

The schedule of use is adjusted depending on the severity, stage and duration of the disease: Longidase® scheduled every other day or with 2-3 day breaks.

Recommended regimens and doses:

• in urology: 1 suppository in a day 10 introductions, then 2-3 days — 10 introductions General course of 20 supp. ;
• in gynecology: vaginally or rectally 1 suppository in 2 days — 10 introductions, further, if necessary, assigned to supportive therapy;
• in dermatology: the suppository in 1-2 days — 10-15 injections;
• in surgery: the suppository 2-3 days — 10 injections;
• in pneumology and Phthisiology: the suppository in 2-4 days — 10-20 injections.

If necessary, a second course of Longidase®is recommended no earlier than 3 months or long-term maintenance therapy — 1 suppository 1 time in 5-7 days for 3-4 months.

Special instructions

When used against the background of exacerbation of foci of infection, to prevent the spread of infection, prescribe under the cover of antimicrobial agents.

If an allergic reaction develops, the use of Longidase should be stopped immediately.

Longidase has no mutagenic or carcinogenic effects.

Use with caution and no more than once a week in patients with renal insufficiency.

Form of production

Suppositories for vaginal or rectal use

Storage conditions

Store in a dry place, protected from light, at a temperature of 8-15 °C

Shelf life

2 years

Active ingredient

Bovhyaluronidase azoximer

Dosage form

rectal suppositories

Description

Children as directed by a doctor, Children over 12 years of age, Adults as directed by a doctor

Indications

Scars, Tuberculosis, Prostatic Hyperplasia, Wounds, Adhesions, Prostatitis