Loratadine pills 10mg Renewal, 10pcs

Composition

Active ingredient: Loratadine -10.0 mg. Auxiliary substance: lactose monohydrate-71.3 mg corn starch-18.0 mg magnesium stearate-0.7 mg

Pharmacological action

Pharmacodynamics

Loratadine is a tricyclic compound with a pronounced antihistamine effect and is a selective blocker of peripheral H1-histamine receptors. It has a fast and long-lasting anti-allergic effect. The onset of action is within 30 minutes after ingestion. The antihistamine effect reaches its maximum after 8-12 hours from the start of action and lasts for more than 24 hours.

Pharmacokinetics

Loratadine is rapidly and well absorbed in the gastrointestinal tract. The time to reach the maximum concentration (Tmax) of loratadine in blood plasma is 1-1.5 hours, and its active metabolite desloratadine is 1.5 ‒ 3.7 hours. Food intake increases the Tmax of loratadine and desloratadine by approximately 1 hour, but does not affect the effectiveness of the drug.

Indications

• seasonal (hay fever) and perennial allergic rhinitis, allergic conjunctivitis, the symptoms associated with these diseases: sneezing, itching of the mucous membrane of the nose, rinoree, burning sensation and itching in the eyes, watery eyes;
• skin diseases of allergic origin (including chronic idiopathic urticaria);
• allergic reactions to insect stings;
• allergic reactions.

Contraindications

Hypersensitivity to loratadine and other components of the drug; lactose intolerance, lactase deficiency, glucose-galactose malabsorption syndrome; breastfeeding period; children under 3 years of age and body weight less than 30 kg.

Side effects

In clinical trials involving children aged 2 to 12 years who took loratadine more often than in the placebo group (“pacifiers”), headache (2.7%), nervousness (2.3%), fatigue (1%) were observed.

In clinical trials involving adults, adverse events that occurred more frequently than with placebo occurred in 2% of patients taking loratadine. In adults, headache (0.6%), drowsiness (1.2%), increased appetite (0.5%), and insomnia (0.1%) were observed more often when using the drug than in the placebo group. In addition, there were very rare reports in the post-marketing period (

If any of the side effects listed in the instructions get worse, or you notice any other side effects not listed in the instructions, tell your doctor.

Interaction

• Food intake does not affect the effectiveness of loratadine.
• Loratadine does not potentiate the effects of alcohol on the central nervous system.
• When loratadine is co-administered with erythromycin, ketoconazole, or cimetidine, an increase in the concentration of loratadine and its active metabolite in blood plasma is noted, but this increase is not clinically significant, including according to ECG data.

How to take, course of use and dosage

• Inside, regardless of food intake.
• Adults, including the elderly and adolescents over 12 years of age,10 mg (1 tablet) 1 time a day.

Children from 3 to 12 years old:

• with a body weight of more than 30 kg,10 mg (1 tablet) 1 time a day;
• with a body weight of less than 30 kg,5 mg (½tablet) 1 time a day.

Adults and children with a body weight of more than 30 kg with severe hepatic impairment, the initial dose should be 10 mg (1 tablet) every other day.

The duration of treatment depends on the duration of symptoms of the disease. If symptoms disappear, the drug should be discontinued, and if symptoms reappear, the drug should be resumed.

When using the drug in elderly patients and in patients with chronic renal failure, no dose adjustment is required. If there is no improvement after treatment or new symptoms appear, you should consult your doctor.

Overdose

Symptoms: headache, drowsiness, tachycardia. In case of overdose, you should immediately consult a doctor.

Treatment: symptomatic and supportive therapy. It is possible to wash the stomach, take adsorbents (crushed activated carbon with water).

Loratadine is not eliminated by hemodialysis. After providing emergency care, it is necessary to continue monitoring the patient’s condition.

Active ingredient

Loratadine

Dosage form

Tablets