Magne B6 pills, 100pcs

Composition

Pill Core: active ingredients: magnesium lactate dihydrate* – 470 mg; pyridoxine hydrochloride-5 mg; excipients: sucrose – 115.6 mg, heavy kaolin-40.0 mg, acacia gum-20.0 mg, carboxypolymethylene 934-10.0 mg, talc (magnesium hydrosilicate) – 42.7 mg, magnesium stearate-6.7 mg. Tablet shell: acacia gum – 3,615 mg, sucrose-214,969 mg, titanium dioxide-1,416 mg, talc (magnesium hydrosilicate) – traces, Carnauba wax (powder) – traces. * – equivalent to magnesium content (Mg++) 48 mg

Pharmacological action

Magnesium is a vital element that is found in all tissues of the body and is necessary for the normal functioning of cells, participates in most metabolic reactions.

In particular, it is involved in regulating the transmission of nerve impulses and in muscle contraction. The body receives magnesium along with food. A lack of magnesium in the body can occur with a violation of the diet (diet) or with an increase in the need for magnesium (with increased physical and mental stress, stress, pregnancy, the use of diuretics).

Pyridoxine (vitamin B6) is involved in many metabolic processes, in regulating the metabolism of the nervous system. Vitamin B6 improves the absorption of magnesium from the gastrointestinal tract and its penetration into cells. Serum magnesium content: – from 12 to 17 mg / l (0.5 – 0.7 mmol/L) indicates moderate magnesium deficiency; – below 12 mg/L (0.5 mmol/L) indicates severe magnesium deficiency.

Pharmacokinetics

Absorption of magnesium in the gastrointestinal tract is not more than 50% of the oral dose. 99% of the body’s magnesium is found inside cells. Approximately 2/3 of intracellular magnesium is distributed in bone tissue, and the other 1/3 is found in smooth and striated muscle tissue. Magnesium is excreted mainly in the urine. At least 1/3 of the magnesium dose taken is excreted in the urine.

Indications

Established magnesium deficiency, isolated or associated with other deficient conditions, accompanied by symptoms such as: increased irritability, minor sleep disturbances; gastrointestinal spasms or rapid heartbeat; increased fatigue, pain and muscle spasms, tingling sensation.

Use during pregnancy and lactation

Clinical experience with the use of the drug in a sufficient number of pregnant women did not reveal any adverse effects on the occurrence of fetal malformations or fetotoxic effects. Magne B6® can be used during pregnancy only if necessary, on the recommendation of a doctor. During breast-feeding, magnesium passes into breast milk. Avoid using the drug during lactation and lactation.

Recommendations for use

Before taking the drug, you should consult your doctor. Coated tablets Adults are recommended to take 6-8 tablets per day. Children over 6 years of age (body weight more than 20 kg) 4-6 tablets per day.

Contraindications

-Hypersensitivity to the components of the drug. – Severe renal insufficiency (creatinine clearance less than 30 ml / minute). – Phenylketonuria. – Children under 6 years of age (for the drug in the form of tablets) and up to 1 year (for the solution). – fructose intolerance, glucose-galactose malabsorption syndrome, sucrose-isomaltase deficiency (only for the drug in tablet form due to the presence of sucrose in the composition). – Simultaneous use of levodopa (see the section “Interaction with other medications”). Use caution in patients with moderate renal insufficiency, as there is a risk of hypermagnesemia.

Side effects

Immune system disorders are very rare (Disorders of the gastrointestinal tract. Unknown frequency (according to available data, it is not possible to estimate the frequency of occurrence): diarrhea, abdominal pain, nausea, vomiting, flatulence.

Interaction

Contraindicated combinations-With levodopa: the activity of levodopa is inhibited by pyridoxine (if taking this drug is not combined with taking peripheral aromatic L-amino acid decarboxylase inhibitors). Any amount of pyridoxine should be avoided if levodopa is not taken in combination with peripheral aromatic L-amino acid decarboxylase inhibitors. Not recommended combinations-Concomitant use of medications containing phosphates or calcium salts may impair intestinal magnesium absorption. Combinations to take into account – When prescribing tetracyclines orally, it is necessary to observe an interval of at least three hours between oral use of tetracycline and Magne B6®, since magnesium preparations reduce the absorption of tetracyclines.

Overdose

With normal renal function, an overdose of magnesium when ingested usually does not lead to toxic reactions. However, in the case of kidney failure, magnesium poisoning may occur. Symptoms of overdose, the severity of which depends on the concentration of magnesium in the blood: decreased blood pressure; nausea, vomiting; depression of the central nervous system, decreased reflexes; changes in the electrocardiogram; respiratory depression, coma, cardiac arrest and respiratory paralysis; anuric syndrome. Treatment: Rehydration, forced diuresis. In case of renal failure, hemodialysis or peritoneal dialysis is necessary.

Special instructions

Information for diabetic patients: coated tablets contain sucrose as an auxiliary substance. In the case of severe magnesium deficiency or malabsorption syndrome, treatment begins with intravenous use of magnesium preparations. In case of concomitant calcium deficiency, it is recommended to eliminate the magnesium deficiency before taking calcium supplements or dietary supplements containing calcium. With frequent use of laxatives, alcohol, strenuous physical and mental stress, the need for magnesium increases, which can lead to the development of magnesium deficiency in the body. Ampoules contain sulfite, which can cause or increase the manifestations of allergic reactions, including anaphylactic reactions, especially in patients at risk. When using pyridoxine in high doses (more than 200 mg per day) for a long time (for several months or in some cases – years) sensory axonal neuropathy may develop, which is accompanied by symptoms such as numbness, impaired proprioceptive sensitivity, distal limb tremor, and gradually developing sensory ataxia (impaired coordination of movements). These disorders are usually reversible and resolve after discontinuation of vitamin B6. The drug in tablet form is intended only for adults and children over 6 years of age. For young children (older than 1 year), the drug is recommended in the form of an oral solution.

Form of production

Film-coated tablets

Storage conditions

Coated tablets: in a dry place protected from light at a temperature not exceeding 25°C

Shelf

life is 2 years.

Active ingredient

Magnesium, Pyridoxine

Dosage form

Tablets