Maxitrol, eye drops, 5ml

Composition

Active ingredients:  

Neomycin sulfate 3500 UNITS;

polymyxin B sulfate 6000 UNITS;

dexamethasone 1 mg;

Auxiliary substances:

hydroxypropylmethylcellulose-0.5%,

polysorbate 20;

neutral additives;

distilled water;

Preservative agent:

benzalkonium chloride — 0.004%.

Pharmacological action

Maxitrol – local antibacterial, local anti-inflammatory.

Pharmacodynamics

Neomycin-has a bactericidal effect, disrupting protein synthesis in the microbial cell. Active in relation to Staphylococcus aureus, Corynebacterium diphtheriae, Streptococcus viridans, Escherichia coli, Klepsiella pneumoniae, Proteus vulgaris, Aerobacter aerogenes, Haemophilus influenzae. It is also not very effective against streptococci. It has no effect on pathogenic fungi, viruses, and anaerobic flora. Resistance of microorganisms to neomycin develops slowly and to a small extent.

Polymyxin B. The mechanism of action is mainly due to the blockade of the permeability of the cytoplasmic membrane of bacterial cells. Active against P. aeruginosa, Aerobacter aerogenes, Escherichia coli, Klepsiella pneumoniae, Koch-Weeks bacillus.

Dexamethasone — corticosteroids. It has anti-inflammatory, anti-allergic and desensitizing effects. It has an anti-exudative effect. Dexamethasone effectively suppresses inflammatory processes.

The combination of dexamethasone with antibiotics reduces the risk of developing an infectious process.

Pharmacokinetics

When applied topically, systemic absorption is low.

Indications

Infections of the eye and its appendages:

• blepharitis,
• conjunctivitis;
• keratoconjunctivitis;
• keratitis;
• iridocyclitis;
• prevention of postoperative inflammation of the anterior eye.

Use during pregnancy and lactation

There is no sufficient experience with the use of the drug during pregnancy and lactation.

It can be used for the treatment of pregnant women as prescribed by the attending physician, if the expected therapeutic effect exceeds the risk of possible side effects. You should stop using the drug for the period of breast-feeding.

Use in children

The safety and efficacy of the drug for children have not been established.

Contraindications

• individual hypersensitivity to any component of the drug;
• viral diseases of the eye (including keratitis caused by herpes simplex, chickenpox);
• mycobacterial infection of the eye;
• tuberculosis eye disease;
• acute herpes zoster;
• fungal diseases of the eye;
• condition after removal of the foreign body of the cornea;
• purulent infection of the mucous membranes of the eye and eyelid caused by resistant to neomycin microorganisms, purulent ulcer of the cornea.

With caution prescribed for glaucoma, cataracts.

Side effects

Local users. Allergic reaction, accompanied by itching and swelling of the eyelids, as well as redness of the conjunctiva. Side effects caused by the steroid component: increased intraocular pressure with possible subsequent development of glaucoma, damage to the optic nerve and visual fields (if the drug is used for more than 10 days, monitoring of intraocular pressure is necessary); posterior subcapsular cataract, slowing down the wound healing process. Topical use of steroids in diseases that cause thinning of the cornea or sclera can lead to their perforation.

Secondary infection

The development of secondary infection is observed after the use of combined drugs containing glucocorticosteroids in combination with antibiotics. With prolonged use of steroids, fungal infections of the cornea may develop. The appearance of non-healing ulcers on the cornea after prolonged treatment with steroid drugs may indicate the development of fungal invasion. Secondary bacterial infection can occur as a result of suppressing the protective reaction of the patient’s body.

Interaction

In the case of use with other topical ophthalmic medications, the interval between their use should be at least 10 minutes.

Interactions with other drugs are currently unknown.

How to take, course of use and dosage

Into the conjunctival sac.

With a mild infectious process,1-2 drops in the conjunctival sac 4-6 times / day.

In acute severe infectious process,1-2 drops into the conjunctival sac every 60 minutes, as the inflammatory phenomena decrease, the frequency of instillation of the drug decreases. Before use, the bottle with drops should be shaken.

Special instructions

The bottle must be closed after each use.

Form of production

Eye drops

Storage conditions

At a temperature of 8-30 °C. (in an upright position)

Shelf life

2 years

Active ingredient

Dexamethasone, Neomycin, Polymyxin B

Conditions of release from pharmacies

By prescription

Dosage form

eye drops

Description

For adults

Indications

Barley on the Eye, Blepharitis, Iridocyclitis, Conjunctivitis, Eye Infections