Meloxicam pills 15mg, 10pcs

Composition

Active ingredient:

meloxicam;

Auxiliary substances:

pregelatinized starch (starch 1500);

MCC;

sodium citrate dihydra;

colloidal silicon dioxide (aerosil 380);

magnesium stearate

Pharmacological action

Pharmaceutical group:

NSAIDs.

Pharmaceutical action:

NSAIDs have anti-inflammatory, antipyretic, and analgesic effects. Belongs to the class of oxycams; a derivative of enolic acid.

The mechanism of action is inhibition of Pg synthesis as a result of selective suppression of COX-2 enzymatic activity. When prescribed in high doses, long-term use and individual characteristics of the body, COX 2 selectivity decreases. Inhibits Pg synthesis in the inflammatory region to a greater extent than in the gastric mucosa or kidneys, which is associated with a relatively selective inhibition of COX-2. Less often causes erosive and ulcerative diseases of the gastrointestinal tract. Pharmacokinetics:

Absorption from the gastrointestinal tract after oral or rectal use is 89%; tablets and suppositories are bioequivalent. Food intake does not affect absorption. The plasma concentration is dose-dependent. TCmax – 5-6 hours. Css is created in 3-5 days. Binding to plasma proteins is 99%. Passes through histohematic barriers, penetrates synovial fluid. The synovial fluid concentration is 50% of the plasma concentration. Metabolism in the liver – to inactive metabolites.

It is excreted through the intestines and kidneys (in approximately equal proportions), unchanged – 5% of the daily dose (through the intestines). T1 / 2-20 hours Plasma clearance is on average 8 ml / min (decreases in the elderly).

Indications

Rheumatoid arthritis; osteoarthritis; ankylosing spondylitis (Ankylosing spondylitis) and other inflammatory and degenerative joint diseases accompanied by pain syndrome. It is intended for symptomatic therapy, reducing pain and inflammation at the time of use; it does not affect the progression of the disease.

Contraindications

Hypersensitivity (including to other NSAIDs), the “aspirin” triad (a combination of bronchial asthma, recurrent nasal and paranasal sinus polyposis, and intolerance to acetylsalicylic acid and pyrazolone-type drugs), acute gastric and duodenal ulcers; gastrointestinal, cerebrovascular or other bleeding; severe heart failure, severe hepatic insufficiency, severe renal failure (if hemodialysis is not performed), pregnancy, breast-feeding, age up to 15 years.

Side effects

From the digestive tract:  dyspepsia, nausea, vomiting, abdominal pain, constipation/diarrhea, flatulence; stomatitis, transient changes in liver function indicators (increased transaminases or bilirubin), belching, esophagitis, stomach and duodenal ulcers, hidden or macroscopically visible gastrointestinal bleeding;

Nervous system and sensory disorders:  headache, dizziness; vertigo, drowsiness, tinnitus;

Cardiovascular and blood disorders (hematopoiesis, hemostasis):  edema, anemia; increased blood pressure, palpitations, flushes of blood to the face, changes in the hemogram, including changes in the number of individual types of white blood cells, leukopenia, thrombocytopenia.

Respiratory system disorders:  exacerbation of bronchial asthma, cough.

From the genitourinary system:  changes in renal function indicators (increased blood creatinine and/or urea levels);

From the side of the skin:  skin rash, pruritus; urticaria;

Interaction

When used concomitantly with other nonsteroidal anti-inflammatory drugs (as well as with acetylsalicylic acid), the risk of erosive and ulcerative lesions and gastrointestinal bleeding increases;

When used concomitantly with antihypertensive drugs, the effectiveness of the latter may decrease;

When used simultaneously with lithium preparations, it is possible to develop lithium accumulation and increase its toxic effect (monitoring of the concentration of lithium in the blood is recommended);

When used concomitantly with methotrexate, the side effect of the latter on the hematopoietic system increases (the risk of anemia and leukopenia, periodic monitoring of the general blood test is indicated);

When used simultaneously with diuretics and cyclosporine, the risk of developing renal failure increases;

When used simultaneously with intrauterine contraceptives, the effectiveness of the latter may decrease;

When used concomitantly with anticoagulants (heparin, ticlopidine, warfarin), as well as with thrombolytic drugs (streptokinase, fibrinolysin), the risk of bleeding increases (periodic monitoring of blood clotting parameters is necessary);

When used concomitantly with colestyramine, meloxicam binding increases its excretion through the gastrointestinal tract.

How to take, course of use and dosage

Meloxicam is taken orally, with meals, without chewing, at a dose of 7.5-15 mg 1 time a day.

The dose is selected individually, and the lowest effective dose should be used for a minimum period of time.

Overdose

Symptoms: impaired consciousness, nausea, vomiting, epigastric pain, gastrointestinal bleeding, acute renal failure, liver failure, respiratory arrest, asystole.

Treatment: there is no specific antidote; in case of overdose of the drug, gastric lavage, taking activated charcoal (within the next hour), symptomatic therapy should be performed. Colestyramine accelerates the elimination of the drug from the body. Forced diuresis, urine alkalinization, and hemodialysis are ineffective due to the high binding of the drug to blood proteins.

Special instructions

If an ulcer or gastrointestinal bleeding occurs, Meloxicam should be discontinued.

Caution should be exercised when prescribing Meloxicam to elderly patients who are more likely to have impaired renal, liver, and heart function.

The drug in the form of candles should not be used for hemorrhoids. With the development of side effects such as dizziness and drowsiness, it is recommended to refrain from driving a car and other potentially dangerous activities that require an increased speed of mental and motor reactions.

Form of production

Tablets

Storage conditions

Store in a dry place, protected from light, at a temperature not exceeding 25 °C

Shelf life

2 years

Active ingredient

Meloxicam

Conditions of release from pharmacies

By prescription

Dosage form

Tablets

Description

For adults as directed by your doctor

Indications

Lumbago, Sciatica, Periarthritis, Osteoarthritis, Sciatica, Osteoarthritis and Arthritis, Osteochondrosis, Rheumatoid Arthritis