Composition
Active ingredients:
minocycline hydrochloride dihydrate (based on minocycline) 100 mg;
Auxiliary substances:
microcrystalline cellulose,
low-molecular-weight povidone,
potato starch,
magnesium stearate,
lactose monohydrate.
Pharmacological action
Minolexin is a semi-synthetic antibiotic from the tetracycline group. It has a bacteriostatic effect on cells of sensitive strains of microorganisms due to reversible inhibition of protein synthesis at the level of 30S ribosomal subunits. It has a wide spectrum of antibacterial activity.
Sensitivity of microorganisms:
Some of the microorganisms listed below have shown resistance to minocycline, so laboratory tests are recommended before use. sensitivity research. Antibiotics of the tetracycline group are not recommended for the treatment of streptococcal and staphylococcal infections, if the sensitivity of microorganisms to minocycline is not shown.
Aerobic gram-positive bacteria: Bacillus anthracis, Listeria monocytogenes, Staphylococcus aureus, Streptococcus pneumoniae.
Aerobic Gram-negative: Bartonella bacilliformis, Brucella species, Calymmatobacterium granulomatis, Campylobacterfetils, Francisella tularensis, Haemophilus ducreyi, Vibrio cholerae, Yersinia pestis.
Indications
Minolexin is used to treat the following diseases, subject to the sensitivity of pathogenic microorganisms:
- Acne
- Skin infections
- Spot fever, typhoid fever, typhoid fever, Ku fever (coxyellosis), vesicular rickettsiosis and tick-borne fever
- Respiratory tract infections Venereal
- lymphogranuloma
- Ornithosis
- Trachoma (infectious keratoconjunctivitis)
- Conjunctivitis with inclusions (paratrachoma)
- Non-gonococcal urethritis, cervical and anal canal infections in adults
- Cyclic fever
- Chancroid
- Plague
- Tularemia
- Cholera
- Brucellosis
- Bartonellez
- Inguinal granuloma
- Syphilis
- Gonorrhea
- Yaws (tropical granuloma, non-venereal syphilis)
- Listeriosis
- Anthrax
- Vincent’s sore throat
- Actinomycosis.
In the case of acute intestinal amoebiasis, minocycline may be used as an adjunct to amoebicidal drugs.
For severe acne. minocycline can be used as an adjunct therapy.
Oral use of minocycline is indicated in asymptomatic carriers of Neisseria meningitidis for the eradication of meningococci from the nasopharynx.
Contraindications
- Hypersensitivity to minocycline, tetracyclines and other components of the drug
- Porphyria
- Severe liver and kidney failure
- Leukopenia
- Pregnancy
- Breast-feeding
- Systemic lupus erythematosus
- Children under 8 years of age (period of dental development)
- Concomitant use with isotretinoin
- : Lactase deficiency, lactose intolerance, glucose-galactose malabsorption.
With caution: Â impaired liver and kidney function, concomitant use with hepatotoxic drugs.
Side effects
From the digestive system: Â anorexia, nausea, vomiting, diarrhea, dyspepsia, stomatitis, glossitis, dysphagia, tooth enamel hypoplasia, enterocolitis, pseudomembranous colitis, pancreatitis, inflammatory diseases (including fungal) in the oral cavity and anogenital region, hyperbilirubinemia, cholestasis, increased content of “liver” enzymes, liver failure, including terminal, hepatitis, including autoimmune.
From the genitourinary system: Â candida vulvovaginitis, interstitial nephritis, dose-dependent increase in urea content in blood plasma.
From the side of the skin: Â baldness, erythema nodosum, nail pigmentation, pruritus, toxic epidermal necrosis, vasculitis, maculopapular and erythematous rash, Stevens-Johnson syndrome, exfoliative dermatitis, balanitis.
From the respiratory tract: Â shortness of breath, bronchospasm, asthma exacerbations, pneumonia.
Musculoskeletal disorders: Â arthralgia, arthritis, limited mobility and joint swelling, discoloration of bone tissue, muscle pain (myalgia).
Allergic reactions: Â urticaria, angioedema, polyarthralgia, anaphylactic reactions (including shock), anaphylactoid purpura (Schonlein Heinoch purpura), pericarditis, exacerbations of systemic lupus, lung infiltration accompanied by eosinophilia.
From the side of hematopoietic organs: Â agranulocytosis, hemolytic anemia, tr 6 mbocytopenia, leukopenia, neutrocytopenia, pancytopenia, eosinopenia, eosyophilia.
From the central nervous system: Â convulsions, dizziness, numbness (including limbs), lethargy, vertigo, increased intracranial pressure in adults, headaches.
From the side of the senses: Â tinnitus and hearing loss.
From the side of metabolism: Â Thyroid gland: an isolated case of malignancy, discoloration (according to the results of pathomorphological studies), functional disorders.
Other services: Â Changes in the color of the oral cavity (tongue, gums, palate), changes in the color of tooth enamel, fever, color of secretions (for example, sweat).
Interaction
Drugs of the tetracycline group reduce the prothrombin activity of blood plasma, which may cause the need to reduce the dose of anticoagulants in patients undergoing anticoagulant therapy.
Due to the fact that bacteriostatic drugs affect the bactericidal effect of penicillins, simultaneous use of drugs of the penicillin and tetracycline groups should be avoided.
Absorption of tetracyclines is impaired when taken concomitantly with antacids containing aluminum, calcium, magnesium or iron-containing drugs, which can lead to a decrease in the effectiveness of antibiotic therapy.
Cases of end-stage renal toxicity have been reported with concomitant use of methoxyfrurane and tetracycline preparations.
Concomitant use of tetracycline antibiotics and oral contraceptives may reduce the effectiveness of contraception.
You should avoid taking isotretinoin immediately before, simultaneously and immediately after taking minocycline, since both drugs can cause a benign increase in intracranial pressure.
Concomitant use of tetracycline preparations with ergot alkaloids and their derivatives increases the risk of ergotism.
How to take, course of use and dosage
Inside, after eating. It is recommended to drink a sufficient amount of liquid (you can use milk) for. reduce the risk of irritation and ulceration in the esophagus.
The initial dose of Minolexin is 200 mg (2 capsules of 100 mg or 4 capsules of 50 mg), then take 100 mg (1 capsule of 100 mg or 2 capsules of 50 mg) every 12 hours (twice a day).
The maximum daily dose should not exceed 400 mg.
Infections of the genitourinary system and anogenital area caused by chlamydia and ureaplasma: Â 100 mg (1 100 mg capsule or 2 50 mg capsules) every 12 hours for 7-10 days.
Acute pelvic inflammatory diseases in women: Â 100 mg (1 100 mg capsule or 2 50 mg capsules) every 12 hours, sometimes in combination with cephalosporins.
Primary syphilis in patients. with increased sensitivity to penicillins: Â 100 mg (1 capsule of 100 mg or 2 capsules of 50 mg) twice a day for 10 to 15 days.
Gonorrhea: Â 100 mg (1 capsule of 100 mg or 2 capsules of 50 mg) twice a day for 4-5 days, or once 300 mg.
Uncomplicated gonococcal infections (excluding urethritis and anorectal infections) in men: Â the initial dose is 200 mg (2 capsules of 100 mg or 4 capsules of 50 mg), the maintenance dose is 100 mg (1 capsule of 100 mg or 2 capsules of 50 mg) every 12 hours for at least 4 days, followed by a microbiological assessment of recovery 2-3 days after discontinuation of the drug.
Uncomplicated gonococcal urethritis in men: Â 100 mg (1 100 mg capsule or 2 50 mg capsules) every 12 hours for 5 days.
Acne: Â 50 mg (1 capsule of 50 mg) per day, a long course of 6-12 weeks.
Overdose
Symptoms: Â The most common symptoms are dizziness, nausea, and vomiting.
Treatment: The selective antidote for minocycline is currently unknown. In case of overdose, it is necessary to stop taking the drug, provide symptomatic treatment and maintenance therapy. Hemo – and peritoneal dialysis removes minocycline in small amounts.
Form of production
Capsules are solid gelatin, No. 2, with a white body and lid; the contents of the capsules are yellow powder.
Storage conditions
In a place protected from light and moisture, at a temperature not exceeding 25 °C
Shelf life
2 years
Active ingredient
Minocycline
Conditions of release from pharmacies
By prescription
Dosage form
Capsules
Purpose
Children as prescribed by a doctor, Children over 8 years of age, Adults as prescribed by a doctor
Indications
Bronchitis, Sore Throat, Skin Infections, Cholecystitis, Prostatitis, Respiratory Tract Infections, Lung Inflammation, Acne, Biliary Tract Infections, Infectious Diseases, Female genital inflammation
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Side effects of Minolexin, capsules 100mg, 20pcs.
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