Miramistin solution for external use 0.01%, spray bottle 50ml

Composition

Topical solution 0.01% colorless, transparent, foaming when shaken.

1 lbenzyldimethyl-myristoylamino-propylammonium chloride monohydrate 100 mg

Auxiliary substances:

purified water-up to 1 l

.50 ml-polyethylene bottles (1) complete with urological applicator-cardboard packs.

Pharmacological action

Miramistin has a broad spectrum of antimicrobial activity, including hospital strains that are resistant to antibiotics.

The drug has a pronounced bactericidal effect against gram-positive (Staphylococcus spp., Streptococcus spp., Streptococcus pneumoniae, etc. ), gram-negative (Pseudomonas aeruginosa, Escherichia coli, Klebsiella spp. , etc. ), aerobic and anaerobic bacteria determined in the form of monocultures and microbial associations, including hospital strains with multiresistance to antibiotics.

Having antifungal activity of the yeasts of the genus Aspergillus and Penicillium genus, yeast (Rhodotorula rubra, Torulopsis gabrata, etc. ) and yeast-like fungi (Candida albicans, Candida tropicalis, Candida krusei, Pityrosporum orbiculare, Malassezia furfur, etc. ), dermatophytes (Trichophyton rubrum, Trichophyton mentagrophytes, Trichophyton verrucosum, Trichophyton schoenleini, Trichophyton violacent, Epidermophyton Kaufman-Wolf, Epidermophyton floccosum, Microsporum gypseum, Microsporum canis, etc. ), as well as other pathogenic fungi, in the form of monocultures and microbial associations, including fungal microflora with resistance to chemotherapeutic drugs.

It has an antiviral effect, is active against complex viruses (herpes viruses, human immunodeficiency virus, and others).

Miramistin acts on pathogens of sexually transmitteddiseases(Chlamydia spp., Treponema spp., Trichomonas vaginalis, Neisseria gonorrhoeae and others).

Effectively prevents infection of wounds and burns. Activates regeneration processes. It stimulates protective reactions at the site of application by activating the absorption and digestion functions of phagocytes, and potentiates the activity of the monocyte-macrophage system. It has a pronounced hyperosmolar activity, as a result of which it stops wound and perifocal inflammation, absorbs purulent exudate, contributing to the formation of a dry scab. It does not damage granulations and viable skin cells, and does not inhibit marginal epithelialization.

It does not have a local irritant effect and allergizing properties.

Indications

For use in surgery and traumatology:

— prevention of suppuration and treatment of purulent wounds—

– treatment of purulent-inflammatory processes of the musculoskeletal system.

For use in obstetrics and gynecology:

— prevention and treatment of suppuration of postpartum injuries, wounds of the perineum and vagina, postpartum infections—

– prevention and treatment of inflammatory diseases (vulvovaginitis, endometritis).

For use in kombustiology:

— treatment of superficial and deep burns of II and III A degrees;

– preparation of burn wounds for dermatoplasty.

For use in dermatology and venereology:

— treatment and prevention of pyoderma and dermatomycosis, candidiasis of the skin and mucous membranes, mycosis of the feet—

– individual prevention of sexually transmitted diseases (including syphilis, gonorrhea, chlamydia, trichomoniasis, genital herpes, genital candidiasis).

For use in urology:

– complex treatment of acute and chronic urethritis and urethroprostatitis of specific (chlamydia, trichomoniasis, gonorrhea) and non-specific nature.

For use in dentistry:

— treatment and prevention of infectious and inflammatory diseases of the oral cavity: stomatitis, gingivitis, periodontitis, periodontitis;

– hygienic treatment of removable dentures.

For use in otorhinolaryngology:

— complex treatment of acute and chronic otitis media, sinusitis, tonsillitis, laryngitis—

– complex treatment of acute pharyngitis and / or exacerbation of chronic tonsillitis in children aged 3 to 14 years.

Contraindications

hypersensitivity to the components of the drug.

Side effects

Local reactions: in some cases, there is a slight burning sensation, which passes on its own after 15-20 seconds and does not require discontinuation of the drug.

Possible: allergic reactions.

Interaction

When used concomitantly with antibiotics, their antibacterial and antifungal properties were enhanced.

How to take, course of use and dosage

Adults

When used in surgery, traumatology, and kombustiology, the surface of wounds and burns is irrigated for preventive and curative purposes, wounds and fistula passages are loosely tamponed, and gauze swabs moistened with the drug are fixed. The treatment procedure is repeated 2-3 times / day for 3-5 days. The method of active drainage of wounds and cavities with a daily consumption of up to 1 liter of the drug is highly effective.

When used in obstetrics and gynecology for the prevention of postpartum infection, it is used in the form of vaginal irrigation before delivery (5-7 days), in childbirth after each vaginal examination and in the postpartum period,50 ml of the drug in the form of a tampon with an exposure of 2 hours, for 5 days. When delivering women by caesarean section, the vagina is treated immediately before the operation, the uterine cavity and incision are treated during the operation, and in the postoperative period, tampons moistened with the drug are inserted into the vagina with an exposure of 2 hours for 7 days. Treatment of inflammatory diseases is carried out in a course of 2 weeks by intra-vaginal injection of tampons with the drug, as well as by drug electrophoresis.

For the prevention of sexually transmitted diseases, the drug is effective if it is used no later than 2 hours after sexual intercourse. Use a urological applicator to insert the contents of the bottle into the urethra for 2-3 minutes: men (2-3 ml), women (1-2 ml) and into the vagina (5-10 ml). Treat the skin of the inner thighs, pubis, and genitals. After the procedure, it is recommended not to urinate for 2 hours.

In the complex treatment of urethritis and urethroprostatitis,2-3 ml of the drug is injected into the urethra 1-2 times / day, the course of treatment is 10 days.

With purulent sinusitis – during the puncture, the maxillary sinus is washed with a sufficient amount of the drug. Tonsillitis, pharyngitis and laryngitis are treated by gargling and / or irrigation with a spray nozzle 3-4-fold pressing 3-4 times / day. The amount of the drug for 1 rinse is 10-15 ml.

For stomatitis, gingivitis, periodontitis, it is recommended to rinse the oral cavity with 10-15 ml of the drug 3-4 times a day.

Children

In acute pharyngitis and/or exacerbation of chronic tonsillitis, the pharynx is irrigated with a spray nozzle. Children aged 3-6 years: a single press on the head nozzle-spray (3-5 ml per 1 irrigation),3-4 times/day; children aged 7-14 years: double tap (5-7 ml per irrigation),3-4 times/day; children over 14 years 3-4 fold by pressing (10-15 ml per irrigation),3-4 times/day. The duration of therapy is from 4 to 10 days, depending on the time of remission.

Rules for using the drug

The drug is ready for use.

Instructions for using the package with the spray nozzle

1. Remove the cap from the bottle.

2. Remove the supplied spray nozzle from its protective packaging.

3. Attach the spray nozzle to the bottle.

4. Activate the spray nozzle by pressing again.

Overdose

There are no data on overdose of Miramistin.

Active ingredient

Benzyldimethyl 3-(myristoylamino) propylammonium chloride monohydrate

Dosage form

solution for topical application

Purpose

For pregnant and lactating women, For children, For adults

Indications

Oral inflammation, Laryngitis, Disinfection, Otitis Media, Skin Infections, Sore Throat, Tonsillitis, Periodontitis, Chlamydia, Purulent wounds