Miramistin solution for external use 0.01% vials, 500ml

Composition

Active ingredient:

benzyldimethyl [3-(myristoylamino)propyl]

ammonium chloride monohydrate (in terms of anhydrous substance) 0.1 g;

Auxiliary substance:

purified water-up to 1 l;

Pharmacological action

Miramistin® It has a broad spectrum of antimicrobial activity, including hospital strains that are resistant to antibiotics.

The drug has a pronounced bactericidal effect against gram-positive (Staphylococcus spp., Streptococcus spp., Streptococcus pneumoniae, etc. ), gram-negative (Pseudomonas aeruginosa, Escherichia coli, Klebsiella spp., etc. ), aerobic and anaerobic bacteria determined in the form of monocultures and microbial associations, including hospital strains with multiresistance to antibiotics.

It has an antifungal effect on ascomycetes of the genus Aspergillus and the genus Penicillium, yeast (Rhodotorula rubra, Torulopsis gabrata, etc. ) and yeast-like fungi (Candida albicans, Candida tropicalis, Candida krusei, Pityrosporum orbiculare (Malassezia furfur), etc. ), dermatophytes (Trichophyton rubrum, Trichophyton mentagrophytes, Trichophyton verrucosum, Trichophyton schoenleini, Trichophyton violent, Epidermophyton Kaufman-Wolf, Epidermophyton floccosum, Microsporum gypseum, Microsporum canis, etc. ), as well as other pathogenic fungi, in the form of monocultures and microbial associations, including fungal microflora with resistance to chemotherapeutic drugs.

It has an antiviral effect, is active against complex viruses (herpes viruses, human immunodeficiency virus, etc. ).

Miramistin ® acts on pathogens of sexually transmitted diseases (Chlamydia spp., Treponema spp., Trichomonas vaginalis, Neisseria gonorrhoeae, etc. ).

Effectively prevents infection of wounds and burns. Activates regeneration processes. It stimulates protective reactions at the site of application by activating the absorption and digestion functions of phagocytes, and potentiates the activity of the monocyte-macrophage system. It has a pronounced hyperosmolar activity, as a result of which it stops wound and perifocal inflammation, absorbs purulent exudate, contributing to the formation of a dry scab. It does not damage granulations and viable skin cells, and does not inhibit marginal epithelialization.

It does not have a local irritant effect and allergizing properties.

Pharmacokinetics

When applied topically, miramistin does not have the ability to be absorbed through the skin and mucous membranes.

Indications

Surgery, traumatology:  prevention of suppuration and treatment of purulent wounds. Treatment of purulent-inflammatory processes of the musculoskeletal system.

Obstetrics and Gynecology:  prevention and treatment of suppuration of postpartum injuries, perineal and vaginal wounds, postpartum infections, inflammatory diseases (vulvovaginitis, endometritis).

Kombustiologiya:  treatment of superficial and deep burns of II and IIIA degrees, preparation of burn wounds for dermatoplasty.

Dermatology, venereology:  treatment and prevention of pyoderma and dermatomycosis, candidiasis of the skin and mucous membranes, mycosis of the feet.

Individual prevention of sexually transmitted diseases (including syphilis, gonorrhea, chlamydia, trichomoniasis, genital herpes, genital candidiasis).

Urology:  complex treatment of acute and chronic urethritis and urethroprostatitis of specific (chlamydia, trichomoniasis, gonorrhea) and non-specific nature.

Dentistry:  treatment and prevention of infectious and inflammatory diseases of the oral cavity: stomatitis, gingivitis, periodontitis, periodontitis. Hygienic treatment of removable dentures.

Otorhinolaryngology:  complex treatment of acute and chronic otitis media, sinusitis, tonsillitis, laryngitis, pharyngitis.

In children aged 3 to 14 years, it is used for the complex treatment of acute pharyngitis and / or exacerbation of chronic tonsillitis.

Contraindications

Individual intolerance to the drug.

Side effects

In some cases, a slight burning sensation may occur at the injection site, which passes independently after 15-20 seconds and does not require discontinuation of the drug.

Allergic reactions.

Interaction

When used concomitantly with antibiotics, their antibacterial and antifungal properties were enhanced.

How to take, course of use and dosage

In the treatment of purulent wounds and burns, the application of gauze bandages moistened with a solution of the drug is prescribed.

In the treatment of acute and chronic urethritis and urethroprostatitis prescribed in combination with other drugs. The solution is injected into the urethra in a volume of 2-5 ml 2-3 times / day for 5-7 days.

To prevent infection of postpartum injuries, tampons soaked in 50 ml of a solution with an exposure of 2 hours for 7 days are administered intravaginally.

For the prevention of sexually transmitted diseases, enter the urethra for men-1.5-3 ml, women-1-1.5 ml; in the vagina-5-10 ml for 2-3 minutes; treat the external genitalia, pubic skin.

Product form

solution for topical application

Storage conditions

At a temperature not exceeding 25 °C.

Shelf life

3 years

Active ingredient

Benzyldimethyl 3-(myristoylamino) propylammonium chloride monohydrate

Dosage form

solution for topical application

Description

For adults, Children over 3 years old, Pregnant and lactating women

Indications

Urethritis, Disinfection, Chlamydia, Skin Infections