Moxonidine Canon pills 0.2mg, 14pcs

Composition

1 film-coated tablet,0.2 mg contains:

Active ingredient:  

moxonidine 0.2 mg;

excipients:

giprolose (hydroxypropylcellulose) 3 mg,

mannitol 68 mg,

croscarmellose sodium 3.3 mg,

magnesium stearate 0.5 mg,

microcrystalline cellulose 25 mg;

film shell composition:

Opadray II pink 3 mg, including: polyvinyl alcohol 1.2 mg, macrogol (polyethylene glycol) 0.606 mg, talc 0.444 mg, titanium dioxide 0.7206 mg, dye sunny sunset yellow 0.0003 mg, dye Indigo Carmine 0.0045 mg, dye crimson [Ponso 4R] 0.0246 mg

Pharmacological action

Pharmacotherapy group:

antihypertensive agent of central action

KodATH:  FROM 02 TO 05

Indications

Arterial hypertension.

Contraindications

-hypersensitivity to the components of the drug;

-severe heart rhythm disorders;

-syndrome of weakness of the sinus node;

-sinoatrial and atrioventricular block II and III degree;

-severe bradycardia (heart rate less than 50 beats/min);

acute and chronic heart failure III and IV functional class NYHA classification;

-a history of angioedema;

-severe liver failure (more than 9 points on a scale child-Pugh);

-chronic renal failure (CC less than 30 ml/min, creatinine more than 160 µmol/l);

-hemodialysis;

-simultaneous use of tricyclic antidepressants;

-age under 18 years (effectiveness and safety not established);

-the age of 75 years;

-the period of lactation.

With caution in

Parkinson’s disease (severe form);

-epilepsy;

-glaucoma;

-depression;

-“intermittent” claudication;

-Raynaud’s disease;

-atrioventricular block I degree;

-chronic renal failure (QC more than 30 ml/min but less than 60 ml/min);

-severe cerebrovascular disorders;

-after myocardial infarction;

severe coronary artery disease;

-severe coronary artery disease or unstable angina (experience of insufficient);

-congestive heart failure I and II functional class NYHA classification;

-disorders of the liver;

-pregnancy.

Side effects

WHO classification of frequency of side effects:

very often – >1/10 appointments (>> 10%)

often – from >1/100 to >< 1/10 appointments (>1% and < 1/10 appointments (>

infrequently – >1/1000 to ><1/100 appointments (>0.1% and <1/100 appointments (><1%)

rarely – >1/10000 to ><1/1000 appointments (>0.01% and <1/1000 appointments (><0.1%)

very rarely – <1/10000 appointments (<0.01%)

Mental disorders

Are Common: reduced concentration of attention. Infrequently: depression, anxiety, nervousness.

Central nervous system disorders

are Common: increased fatigue, drowsiness, headache, dizziness.

Infrequently: paresthesia, insomnia, fainting.

Disorders of the gastrointestinal tract

Often: dryness of the oral mucosa, constipation, dyspeptic disorders.

Infrequently: nausea, anorexia.

Very rare: hepatitis, cholestasis.

Skin and subcutaneous tissue disorders

Infrequently: skin rash, pruritus, edema of various localization.

Very rare: angioedema.

Disorders of the genitourinary system

Infrequently: urinary retention or incontinence, impotence, decreased libido.

Liver and biliary tract disorders

Rare: hepatitis, bile stasis.

Visual disturbances

Infrequently: dry eyes that cause itching or burning sensation in the eyes.

Hearing disorders and labyrinth disorders

Infrequently: ringing in the ears.

Vascular disorders

Often: symptoms of vasodilation.

Infrequently: low blood pressure( BP), orthostatic hypotension, Raynaud’s syndrome, peripheral circulation disorders.

Endocrine system disorders

Infrequently: gynecomastia.

Musculoskeletal and connective tissue disorders:

Common: back pain. Infrequently: neck pain.

General disorders and disorders at the injection

site Often: asthenia. Infrequently: weakness in the legs, fainting, pain in the parotid glands.

Interaction

Moxonidine Canon can be prescribed with thiazide diuretics and slow calcium channel blockers. The combined use of Moxonidine Canon with these and other antihypertensive agents leads to an additive effect and an increase in the antihypertensive effect.

When Moxonidine Canon is prescribed with hydrochlorothiazide, glibenclamide (glyburide) or digoxin, there is no pharmacokinetic interaction.

Tricyclic antidepressants can reduce the effectiveness of central antihypertensive agents, so their simultaneous use is not recommended.

Moxonidine Canon modestly enhances cognitive decline in patients taking lorazepam.

use of the drug Moxonidine Canon together with benzodiazepine derivatives may be accompanied by an increase in the sedative effect of the latter.

The drug Moxonidine Canon enhances the depressing effect on the central nervous system of anxiolytics, barbiturates and ethanol.

Beta-blockers when combined with moxonidine increase bradycardia, the severity of negative ino-and dromotropic effects.

When Moxonidine Canon is administered together with moclobemide, there is no pharmacodynamic interaction.

How to take, course of use and dosage

Inside, regardless of food intake, with a sufficient amount of liquid. In most cases, the initial dose of Moxonidine Canon is 0.2 mg per day, in one dose, preferably in the morning. If the therapeutic effect is insufficient, the dose can be increased after 3 weeks of therapy to 0.4 mg per day, which should be divided into 2 doses (morning and evening) or once.

The maximum daily dose, which should be divided into 2 doses (morning and evening), is 0.6 mg. The maximum single dose is 0.4 mg.

In elderly patients with normal renal function, the dosage recommendations are the same as for adult patients.

In patients with renal insufficiency (creatinine clearance 30-60 ml/min) and patients on hemodialysis, a single dose should not exceed 0.2 mg, the maximum daily dose is 0.4 mg.

Overdose

Symptoms: headache, sedation, drowsiness, marked decrease in blood pressure, dizziness, general weakness, bradycardia, increased fatigue, dryness of the oral mucosa, vomiting and stomach pain. Paradoxical increase in blood pressure, tachycardia, and hyperglycemia are also potentially possible.

Treatment: there is no specific antidote. Gastric lavage (immediately after ingestion), taking activated charcoal and laxatives, symptomatic therapy. In the case of a marked decrease in blood pressure, it is recommended to restore the volume of circulating blood through the introduction of fluid and the introduction of dopamine. Bradycardia can be treated with atropine.

Alpha-adrenergic antagonists may reduce or eliminate transient arterial hypertension in the event of an overdose with Moxonidine Canon.

Special instructions

If it is necessary to cancel simultaneously taking beta-blockers and the drug Moxonidine Canon, first cancel beta-blockers and only after a few days the drug Moxonidine Canon.

It is not recommended to prescribe tricyclic antidepressants simultaneously with Moxonidine Canon.

During treatment, regular monitoring of blood pressure, heart rate and ECG is necessary.

The drug Moxonidine Canon can be prescribed with thiazide diuretics, angiotensin converting enzyme (ACE) inhibitors and slow calcium channel blockers.

Stop taking the drug Moxonidine Canon should be gradually.

Influence on the ability to drive vehicles and mechanisms

Taking into account the possible occurrence of drowsiness and dizziness during treatment with Moxonidine Canon, patients should exercise caution when engaging in potentially dangerous activities that require increased attention, such as driving vehicles or operating equipment that requires increased concentration of attention.

Form of production

Tablets are round, biconvex, film-coated in pink color (dosages of 0.2 mg and 0.4 mg) or dark pink color (dosage of 0.3 mg). The cross-section is almost white in color. Slight roughness is allowed.

Active ingredient

Moxonidine

Conditions of release from pharmacies

By prescription

Dosage form

Tablets

Purpose

For adults as prescribed by a doctor, for pregnant women as prescribed by a doctor

Indications

Hypertension