Neupilept solution 125mg/ml ampoules 4ml 5pcs

Composition

Composition (1 ml / 1 amp. ):

• Active ingredient:
• citicoline sodium (based on citicoline) 125 mg;
• excipients:
• Hydrochloric acid 1 M or sodium hydroxide solution 1 M-up to pH 6.5-7.5, water d/i-up to 4 ml

Pharmacological action

Citicoline is a natural endogenous compound that is an intermediate metabolite in the synthesis of phosphatidylcholine — one of the main structural components of the cell membrane.

It has a broad spectrum of action-it helps restore damaged cell membranes, inhibits the action of phospholipases, prevents excessive formation of free radicals, and also prevents cell death by affecting the mechanisms of apoptosis. In the acute period of stroke, citicoline reduces the amount of damage to brain tissue, improves cholinergic transmission. With TBI, it reduces the duration of post-traumatic coma and the severity of neurological symptoms, in addition, it helps to reduce the duration of the recovery period.

In chronic brain hypoxia, citicoline is effective in treating cognitive disorders such as memory loss, lack of initiative, difficulties in performing daily activities and self-care. Increases the level of attention and consciousness, and also reduces the manifestation of amnesia.

Citicoline is effective in the treatment of sensory and motor neurological disorders of degenerative and vascular etiology.

Metabolism

After intravenous use, citicoline is rapidly hydrolyzed to choline and cytidine and delivered to various body tissues.

Distribution

After use, citicoline is widely distributed in brain structures with rapid incorporation of choline fractions into structural phospholipids and cytidine fractions into cytidine nucleotides and nucleic acids. After reaching the brain, citicoline is embedded in cellular, cytoplasmic and mitochondrial membranes, taking part in the construction of the phospholipid fraction.

Deduction

Only a small amount of the dose is excreted by the kidneys and through the intestines

Indications

• Acute period of ischemic stroke (as part of complex therapy);
• recovery period of ischemic and hemorrhagic strokes;
• traumatic brain injury, acute (as part of complex therapy) and recovery period;
• cognitive and behavioral disorders in degenerative diseases

Contraindications

• Hypersensitivity to any of the components of the drug;
• should not be prescribed to patients with severe vagotonia (high tone of the parasympathetic part of the autonomic nervous system);
• due to the lack of sufficient clinical data, it is not recommended to use in children under 18 years of age.

Side effects

From the nervous system and sensory organs: sleep disorders, including insomnia or drowsiness, increased excitability, fatigue, impaired attention, restlessness, anxiety, headache, dizziness, extrapyramidal disorders (rigidity, hypokinesia, hypersalivation, akathisia, acute dystonia), tardive dyskinesia, neuroleptic malignant syndrome, thermoregulation disorders, convulsive seizures, stroke (in predisposed elderly patients), blurred vision. Cardiovascular and blood disorders (hematopoiesis, hemostasis): orthostatic hypotension, reflex tachycardia, arterial hypertension, neutro-and thrombopenia, thrombocytopenic purpura. Gastrointestinal disorders: nausea, vomiting, dyspeptic symptoms, abdominal pain, constipation, increased levels of hepatic transaminases. From the genitourinary system: dysmenorrhea, amenorrhea, impotence, erectile dysfunction and ejaculation, anorgasmia, decreased libido, priapism, polyuria, urinary incontinence, edema. Allergic reactions: skin rash, angioedema. Others: rhinitis, galactorrhea, gynecomastia, weight gain, hypervolemia (due to polydipsia or syndrome of inadequate ADH secretion), hyperglycemia (in patients with diabetes mellitus).

The interaction of

Citicoline enhances the effects of levodopa.

How to take, course of use and dosage

Acute period of ischemic stroke and traumatic brain injury( TBI): 1000 mg of citicoline every 12 hours from the first day after diagnosis, the duration of treatment is at least 6 weeks.

The maximum daily dose is 2000 mg.

Recovery period of ischemic and hemorrhagic strokes, recovery period of TBI, cognitive and behavioral disorders in degenerative and vascular diseases of the brain

Enter IV or iv 500-2000 mg of citicoline per day. Dosage and duration of treatment depending on the severity of the symptoms of the disease.

Elderly patients

When prescribing Neupilept® to elderly patients, no dose adjustment is required.

The drug should be used immediately after opening the ampoule.

Neupilept® is administered intravenously, intravenously in a jet (slowly, for 3-5 minutes, depending on the prescribed dose) or drip (infusion rate-40-60 drops per minute).

IV route of use is preferable to IV. With intravenous use, repeated use of the drug in the same place should be avoided.

Neupilept® is compatible with all types of intravenous isotonic solutions and dextrose solutions.

Overdose

Given the low toxicity of Neupilept®, no overdose cases have been described.

Special instructions

Neupilept® is administered intravenously slowly (3-5 minutes depending on the dose). When administered intravenously, the infusion rate should be 40-60 drops per minute.

In case of persistent intracranial hemorrhage, it is recommended not to exceed the dose of Neupilept ® 1000 mg / day, the drug is administered intravenously at a rate of 30 drops per minute.

Influence on the ability to drive vehicles and mechanisms

During the use of the drug, care should be taken when driving vehicles and when engaging in other potentially dangerous activities that require increased concentration of attention and speed of psychomotor reactions.

Storage conditions

At a temperature not exceeding 25 °C. Keep out of reach of children.

Shelf

life is 2 years.

Active ingredient

Citicoline

Conditions of release from pharmacies

By prescription

Dosage form

solution for injection and infusion

Description

For adults as directed by your doctor

Indications

Concussion and other traumatic brain injuries, Consequences of stroke