Neurodiklovit, modified-release capsules 30pcs

Composition

One capsule contains:

Active ingredients:

• diclofenac sodium 50.0 mg;
• a mixture of vitamins: thiamine hydrochloride 50.0 mg; pyridoxine hydrochloride 50.0 mg;
• cyanocobalamin 0.25 mg.

Auxiliary substances:

povidone K 25 8.42 mg,

methacrylic acid and ethyl acrylate copolymer (1 : 1) dispersion 30% 5.60 mg,

triethyl citrate 0.60 mg, talc 3.08 mg.

Capsule shell: body:

titanium dioxide (E 171) 0.9240 mg,

dye iron oxide red (E 172) 0.0061 mg,

dye iron oxide yellow (E 172) 0.0924 mg,

gelatin 45.1775 mg

Pharmacological action

Neurodyclovit has an anti-inflammatory, analgesic effect.

Indications

• pain syndrome in non-rheumatic inflammations
• inflammatory and degenerative diseases of the joints and spine (chronic polyarthritis, rheumatic and rheumatoid arthritis, ankylosing spondylitis, osteoarthritis, spondyloarthritis)
• neuritis and neuralgia (cervical syndrome, lumbago, sciatica)
• acute gouty arthritis
• is a rheumatic soft tissue disorder.

Use during pregnancy and lactation

Neurodyclovitis is not recommended for children under 18 years of age, pregnant women and during lactation.

Contraindications

• individual intolerance to the components of Neurodyclovitis, erosive and ulcerative lesions of the gastrointestinal tract in the acute phase
• bleeding from the gastrointestinal
• tract intracranial hemorrhages
• hematopoietic
• disorders hemostasis disorders (including hemophilia).

Side effects

Possible allergic reactions, diarrhea, nausea, headache.

Interaction

The drug increases the plasma concentrations of digoxin, methotrexate, lithium and cyclosporine.

Reduces the effect of diuretics, against the background of potassium-sparing diuretics, the risk of hyperkalemia increases; against the background of anticoagulants, thrombolytics (alteplase, streptokinase, urokinase)-the risk of bleeding (more often from the gastrointestinal tract).

Reduces the effects of antihypertensive and hypnotic medications.

Increases the likelihood of side effects of other NSAIDs and glucocorticosteroids (bleeding in the gastrointestinal tract), methotrexate toxicity and cyclosporine nephrotoxicity.

Acetylsalicylic acid reduces the concentration of diclofenac in the blood.

Concomitant use with paracetamol increases the risk of nephrotoxic effects of diclofenac.

Reduces the effect of hypoglycemic agents.

Cefamandol, cefoperazone, cefotetan, valproic acid, and plicamycin increase the incidence of hypoprothrombinemia.

Cyclosporine and gold preparations increase the effect of diclofenac on prostaglandin synthesis in the kidneys, which increases nephrotoxicity.

Concomitant use with ethanol, colchicine, corticotropin, serotonin reuptake inhibitors, and St. John’s wort increases the risk of gastrointestinal bleeding.

Diclofenac enhances the action of drugs that cause photosensitization.

Antibacterial drugs from the quinolone group – the risk of seizures.

Drugs that block tubular secretion increase the plasma concentration of diclofenac, thereby increasing its toxicity.

The drug reduces the antiparkinsonian effectiveness of levodopa.

Ethanol dramatically reduces the absorption of thiamine (blood levels can drop by 30%). Long-term treatment with anticonvulsants can lead to thiamine deficiency. The use of colchicine and biguanides reduces the absorption of cyanocobalamin. While taking the drug, it is not recommended to take multivitamin complexes that include B vitamins.

How to take, course of use and dosage

Inside, while eating, without chewing, drinking plenty of liquid.

Adults: 1 capsule: at the beginning of treatment-3 times a day, as a maintenance dose — 1-2 times a day.

The duration of therapy depends on the nature and severity of the disease.

Adult Neurodyclovit is prescribed 1 capsule-at the beginning of treatment 3 times a day, as a maintenance dose – 1-2 times a day.

The duration of therapy depends on the nature and severity of the disease.

Overdose

Symptoms: vomiting, bleeding from the gastrointestinal tract( GIT), epigastric pain, diarrhea, dizziness, tinnitus, lethargy, convulsions; rarely – increased blood pressure, acute renal failure, hepatotoxic effect, respiratory depression, coma.

Treatment: gastric lavage, activated charcoal, symptomatic therapy aimed at eliminating high blood pressure, impaired renal function, convulsions, gastrointestinal irritation, respiratory depression.

Forced diuresis and hemodialysis are ineffective (due to significant protein binding and intensive metabolism).

Special instructions

Patients taking the drug should refrain from activities that require increased attention and rapid mental and motor reactions, as well as alcohol consumption.

Form of production

Modified-release capsules.

Storage conditions

In a dry place protected from light, at a temperature not exceeding 25 °C. Keep out of reach of children! 

Shelf

life is 3 years. Do not use after the expiration date.

Active ingredient

Diclofenac Sodium, Thiamine, Pyridoxine, Cyanocobalamin

Conditions of release from pharmacies

By prescription

Dosage form

long-acting capsules

Description

For adults as directed by your doctor

Indications

Sciatica, Sciatica, Osteoarthritis, Gout, Periarthritis, Osteoarthritis, Arthritis, Neuritis, Pharyngitis, Adnexitis, Rheumatoid Arthritis, Lumbago, Osteochondrosis, Tonsillitis