Nifural capsules 200mg, 16pcs

Composition

1 capsule contains:

Active ingredient:

nifuroxazide 100 / 200 mg;

excipients:

sugar (sucrose),

category “extra”,

corn starch,

microcrystalline cellulose,

magnesium stearate;

hard gelatin capsule:

capsule body and lid – titanium dioxide,

yellow iron oxide,

gelatin.

Pharmacological action

Pharmacotherapeutic group:

antimicrobial agent-nitrofuran.

ATX code: A 07 AX 03.

Pharmacological action

Pharmacodynamics

Nifuroxazide is an intestinal antiseptic, a 5-nitrofuran derivative, highly active against Campylobacter jejuni, Escherichia coli, Salmonella spp, Shigella spp; Clostridium perfingens, Vibrio cholerae, pathogenic Vibrions and Vibrio parahaemolytique, Staphylococcus spp. Citrobacter spp, Enterobacter cloacae and Proteus indologenes are weakly sensitive to nifuroxazide. Resistant to nifuroxazide: Klebsiella spp, Proteus mirabilis, Providencia spp, Pseudomonas spp.

Nifuroxazide presumably inhibits dehydrogenase activity and protein synthesis in bacterial cells. It does not cause the appearance of drug-resistant strains, and cross-resistance with other antibacterial drugs has not been observed. The effectiveness of nifuroxazide does not depend either on the pH present in the intestinal lumen or on the sensitivity of microorganisms to antibacterial drugs. It does not affect the composition of the normal bacterial flora of the digestive tract.

In acute bacterial diarrhea, it restores intestinal eubiosis. When infected with enterotropic viruses, it prevents the development of bacterial superinfection.

Pharmacokinetics

After oral use, nifuroxazide is practically not absorbed from the digestive tract and has its antibacterial effect exclusively in the intestinal lumen. Nifuroxazide is excreted by the intestines: 20% unchanged, and the remaining amount of nifuroxazide is chemically altered.

Indications

Acute bacterial diarrhea that occurs without deterioration of the general condition, fever, intoxication.

Contraindications

Hypersensitivity to nifuroxazide, nitrofuran derivatives or any excipients of the drug, sucrose/isomaltase deficiency, fructose intolerance, glucose-galactose malabsorption, pregnancy, children under 3 years of age.

How to take, course of use and dosage

It is applied inside. The capsule should be swallowed whole, washed down with a small amount of water.

Children from 3 to 6 years: 2 capsules of 100 mg or 1 capsule of 200 mg 3 times a day (the interval between doses is 8 hours).

Children from 6 to 18 years: 2 capsules of 100 mg or 1 capsule of 200 mg 3-4 times a day (the interval between doses is 6-8 hours).

Adults: 2 capsules of 100 mg or 1 capsule of 200 mg 4 times a day (the interval between doses is 6 hours).

The duration of treatment is 5-7 days, but not more than 7 days. If there is no improvement during the first 3 days of taking it, then you should consult a doctor.

Use the drug only according to the method of use and in the doses indicated in the instructions. If necessary, please consult your doctor before using the medicine.

Active ingredient

Nifuroxazide

Dosage form

Capsules