Nimica, pills 100mg, 20pcs

Composition

1 tablet contains:  

Active ingredients:

nimesulide – 100 mg

Auxiliary substances:

starch,

microcrystalline cellulose,

colloidal silicon dioxide,

gelatinized starch,

citric acid monohydrate,

purified talc,

starch glycolate sodium salt,

aspartame,

fruit flavor (for 100 mg tablets) magnesium stearate,

purified water.

Pharmacological action

Nimica is a nonsteroidal anti-inflammatory drug (NSAID) from the class of sulfonanilides. It has anti-inflammatory, analgesic and antipyretic effects.

Nimisulide belongs to a new generation of NSAIDs, the mechanism of action of which is associated with selective inhibition of cyclooxygenase II and the effect on a number of other factors: suppression of platelet activation factor, tumor necrosis factor alpha, suppression of proteinases and histamine.

Pharmacokinetics

When taken orally, it is well absorbed from the gastrointestinal tract. The maximum concentration of the Active ingredient in the blood plasma is reached in 1.5-2.5 hours after taking the drug.

The use of the drug simultaneously with food reduces the rate of absorption, but does not affect its degree. Binding to plasma proteins is 99%, the volume of distribution is 0.19-0.35 l / kg. Nimesulide is actively metabolized in the liver with the formation of several metabolites, mainly excreted in the urine (70%) and feces (30%).

In patients with renal insufficiency (creatinine clearance 30-80 ml/min), as well as in children and the elderly, the pharmacokinetic profile of nimesulide did not change significantly.

Indications

• arthritis
• pain of various origins (dental and menstrual pain, injuries)
• high temperature.

Use during pregnancy and lactation

Nimika is contraindicated during pregnancy and lactation.

Contraindications

• severe renal dysfunction
• erosive and ulcerative lesions of the stomach
• hypersensitivity to the drug Facial expressions.

Side effects

Nervous system and sensory disorders:  rarely — headache, dizziness, drowsiness.

Cardiovascular and blood disorders (hematopoiesis, hemostasis):  very rarely — thrombocytopenia.

From the digestive tract:  rarely — nausea, heartburn, stomach pain, tarry stools, melena.

From the side of the skin:  rarely-petechiae, purpura.

From the genitourinary system:  rarely-oliguria.

Allergic reactions:  exanthema, erythema, urticaria.

Interaction

Caution should be exercised when using Nimesulide concomitantly with:  

• digoxin, phenytoin, and lithium preparations;
• diuretics and antihypertensive agents; 
• other NSAIDs;
• anticoagulants; 
• cyclosporine;
• methotrexate;
• oral antidiabetic agents.

because at the level of binding to plasma proteins, Nimesulide increases the concentration of drugs competing for protein binding.

How to take, course of use and dosage

Inside

• adults 100-200 mg 2 times/day,
• children-1.5 mg / kg 2-3 times/day.

The maximum dose for children is 5 mg / kg / day in 2-3 divided doses.

Special instructions

With caution, it is used simultaneously with diuretics, blood pressure medications, other painkillers, anti-inflammatory, antidiabetic drugs.

Form of production

Dispersible tablets

Storage conditions

Store in a dry place, protected from light, at a temperature not exceeding 25 °C

Shelf life

2 years

Active ingredient

Nimesulide

Conditions of release from pharmacies

By prescription

Dosage form

Tablets

Description

For children over 12 years of age, For adults as prescribed by a doctor, For Children as prescribed by a doctor

Indications

Bursitis, Gout, Osteochondrosis, Myositis, Sciatica, Sciatica, Lumbago, Migraines, Sprains and Sprains, Tendon Inflammation, Arthritis, Osteoarthritis, Rheumatoid Arthritis