Norfloxacin pills 400mg, 10pcs

Composition

Active ingredient:

norfloxacin 400 mg;

Auxiliary substances:

colloidal silicon dioxide (aerosil),

magnesium stearate,

microcrystalline cellulose,

croscarmellose sodium,

crospovidone.

Pharmacological action

Norfloxacin is an antimicrobial synthetic agent of the broad-spectrum fluoroquinolone group. It has a bactericidal effect. By suppressing DNA gyrase, it disrupts the process of DNA supercoiling.

Highly active against most gram-negative bacteria: Escherichia coli, Salmonella spp., Shigella spp., Proteus spp., Morganella morganii, Klebsiella spp. (including Klebsiella pneumoniae), Enterobacter spp., Serratia spp., Citrobacter spp., Yersinia spp., Providencia spp., Haemophilus influenzae, Pseudomonas aeruginosa, Neisseria gonorrhoeae, Neisseria meningitidis.

It is active against some Gram-positive bacteria (including Staphylococcus aureus).

Anaerobic bacteria are resistant to norfloxacin, Enterococcus spp. and Acinetobacter spp. are insensitive.

Resistant to beta-lactamases.

Pharmacokinetics

When taken orally, about 30-40% is absorbed, and food intake reduces the rate of absorption. Binding to plasma proteins is 14%. Norfloxacin is well distributed in the tissues of the urogenital system. Penetrates the placental barrier. About 30% is excreted unchanged in the urine.

Indications

Diseases of the urinary tract, prostate, gastrointestinal tract, gonorrhea, prevention of recurrent urinary tract infections, bacterial infections in patients with granulocytopenia, “traveler’s diarrhea”.

Contraindications

Pregnancy, lactation (breastfeeding), childhood and adolescence (up to 15 years), glucose-6-phosphate dehydrogenase deficiency, hypersensitivity to norfloxacin and other quinolone drugs.

Side effects

From the central nervous system (CNS): dizziness, headache, tingling in the fingers, drowsiness, anxiety, depression, insomnia, sleep disorders.

From the digestive system: nausea, abdominal pain, anorexia, diarrhea, pain in the rectum or anus, constipation, dyspepsia, flatulence, vomiting, dry oral mucosa, heartburn, loose stools, bitter taste in the mouth, ulceration of the oral mucosa, itching of the anus.

Hematopoietic disorders: leukopenia, thrombocytopenia, eosinophilia, neutropenia.

From the skin: pruritus, rash, erythema, urticaria.

From the side of the senses: blurred visual perception.

Musculoskeletal system disorders: bursitis, swelling of the hands and feet.

From the cardiovascular system (CVS): myocardial infarction, palpitation sensation.

From the urinary system: renal colic.

Laboratory parameters: increased activity of AST, ALT, ALP, LDH, proteinuria, decreased hematocrit and Hb, increased blood urea concentration, hypercreatininemia, glucosuria.

Other: hyperhidrosis, asthenia, back pain, fever, chills, chest pain, dysmenorrhea, edema, allergic reactions.

Interaction

Concomitant use of norfloxacin with warfarin increases the anticoagulant effect of the latter.

With the simultaneous use of norfloxacin with cyclosporine, an increase in the concentration of the latter in blood plasma is noted.

When taking norfloxacin and antacids or preparations containing iron, zinc, magnesium, calcium or sucralfate at the same time, the absorption of norfloxacin decreases due to the formation of complexes with metal ions (the interval between their intake should be at least 4 hours).

Concomitant use of norfloxacin reduces the clearance of theophylline by 25%, so when used simultaneously, the dose of theophylline should be reduced.

Concomitant use of norfloxacin with drugs that have the potential to reduce blood pressure can cause a sharp decrease in blood pressure. In this regard, in such cases, as well as with the simultaneous use of barbiturates, anesthetics, heart rate, blood pressure, ECG indicators should be monitored. Concomitant use with drugs that lower the epileptic threshold may lead to the development of epileptiform seizures.

Reduces the effect of nitrofurans.

How to take, course of use and dosage

Inside.

For urinary tract infections-400 mg 2 times a day for 7-10 days; for uncomplicated cystitis-3-7 days; for chronic recurrent urinary tract infection-up to 12 weeks.

For acute bacterial gastroenteritis – 5 days.

In acute gonococcal urethritis, pharyngitis, proctitis, cervicitis – once 800 mg.

For typhoid fever – 400 mg 3 times a day for 14 days.

For the prevention of sepsis – 400 mg 2 times a day.

For the prevention of bacterial gastroenteritis-400 mg/day.

For the prevention of travelers ‘ diarrhea-400 mg / day 1 day before departure and during the entire travel period (no more than 21 days).

For the prevention of recurrent urinary tract infections-200 mg/day.

In patients with impaired renal function with creatinine clearance greater than 20 ml/min, no dosage adjustment is required. If creatinine clearance is less than 20 ml / min (or serum creatinine concentration is more than 5 mg / 100 ml) and patients on hemodialysis are prescribed 1/2 therapeutic dose 2 times a day or the full dose 1 time a day.

Overdose

In the event of an overdose, the stomach should be cleared by inducing vomiting or by gastric lavage with a probe, and the patient should be thoroughly examined and treated with symptomatic and supportive care.

It is necessary to monitor the water-salt metabolism, the patient should receive a large amount of fluid to avoid the formation of stones in the urinary tract.

Special instructions

Use the drug with caution in the following diseases:

Epilepsy, convulsive syndrome, renal / hepatic insufficiency, myasthenia gravis.

During the treatment period, patients should receive a sufficient amount of fluid (under the control of diuresis).

During therapy, an increase in the prothrombin index is possible (during surgical interventions, the state of the blood coagulation system should be monitored).

During treatment, avoid exposure to direct sunlight.

Norfloxacin, like other fluoroquinolones, can cause tendinitis and tendon rupture. Risk factors: age over 60 years, taking glucocorticosteroids, kidney, heart or lung transplantation, increased physical activity, CRF, a history of tendon damage (including rheumatoid arthritis). These phenomena may occur several months after the end of taking the drug. At the first sign of tendinitis or tendon rupture, you should stop taking norfloxacin and consult a doctor.

Norfloxacin can lower the threshold of convulsive readiness and cause seizures; fluoroquinolones can also stimulate the central nervous system, causing tremors, toxic psychoses, anxiety, confusion and hallucinations; increased intracranial pressure.

Norfloxacin can lead to the development of pseudomembranous colitis caused by Clostridium difficile. In this case, it is necessary to cancel the drug and prescribe appropriate treatment (the use of vancomycin inside or metronidazole).

Not effective for syphilis.

Norfloxacin may cause peripheral neuropathy (paresthesia, hypesthesia, dysesthesia, muscle weakness). At the first sign of neuropathy (pain, tingling, numbness or weakness in the extremities, violation of other types of sensitivity), the drug should be discontinued in order to avoid irreversible changes.

To avoid the formation of crystals of norfloxacin in the kidneys, do not exceed the recommended doses; it is necessary to take tablets with a sufficient amount of liquid.

Storage conditions

The drug should be stored at a temperature not exceeding 25°C out of the reach of children.

Shelf

life is 2 years.

Active ingredient

Norfloxacin

Conditions of release from pharmacies

By prescription

Dosage form

Tablets