Novocaine, ampoules 0.5%, 10ml, 10pcs

Composition

Active ingredients:

procaine hydrochloride 5 mg

Pharmacological action

Novocaine is a local anesthetic.

It accumulates in the membranes of nerve fibers and endings and interacts with receptors located in potential-dependent sodium channels.

Reduces the permeability of membranes to sodium ions, preventing the emergence of an action potential and the conduct of a pain impulse.

Indications

• various types of local anesthesia,
• anal fissures,
• hemorrhoids.

Contraindications

Hypersensitivity.

Side effects

• dizziness,
• weakness,
• hypotension,
• allergic reactions.

Interaction

Prolongs neuromuscular blockade caused by suxamethonium (since both drugs are hydrolyzed by plasma cholinesterase).

Concomitant use with MAO inhibitors (furazolidone, procarbazine, selegelin) increases the risk of hypotension. Procaine toxicity is increased by anticholinesterase drugs (which inhibit its hydrolysis). The procaine metabolite (paraaminobenzoic acid) is a competitive antagonist of sulfonamide preparations and may weaken their antimicrobial action.

When treating the injection site of a local anesthetic with disinfection solutions containing heavy metals, the risk of developing a local reaction in the form of soreness and swelling increases.

Potentiates the action of direct anticoagulants.

Preprate reduces the effect of anticholinesterase agents on neuromuscular transmission.

Possible cross-sensitisation.

How to take, course of use and dosage

Novocaine is administered intramuscularly-5-10 ml of 1-2% solution 3 times a week for a month, after which a 10-day break is made; for infiltration anesthesia,0.25-0.5% solutions are used, for conduction-2% solution.

Inside-1/2 teaspoon (for pain).

Overdose

Symptoms: pallor of the skin and mucous membranes, dizziness, nausea, vomiting, increased nervous excitability, cold sweat, tachycardia, decreased blood pressure almost to collapse, tremor, convulsions, apnea, methemoglobinemia, respiratory depression, sudden cardiovascular collapse.

The effect on the central nervous system is manifested by a feeling of fear, hallucinations, convulsions, motor excitement. In cases of overdose, the drug should be discontinued immediately. When performing local anesthesia, the injection site can be pricked with epinephrine.

Treatment: general resuscitation measures, which include oxygen inhalation, if necessary, artificial ventilation of the lungs. If seizures last more than 15-20 seconds, they are stopped by intravenous use of thiopental (100-150 mg) or diazepam (5-20 mg). In case of arterial hypotension and/or myocardial depression, ephedrine (15-30 mg) is administered intravenously, in severe cases detoxification and symptomatic therapy.

In case of intoxication after injection of novocaine into the muscles of the leg or arm, an urgent tourniquet is recommended to reduce the subsequent intake of the drug into the general bloodstream.

Special instructions

During the treatment period, care should be taken when driving vehicles and engaging in other potentially dangerous activities that require increased concentration of attention and speed of psychomotor reactions.

 Patients require monitoring of the functions of the cardiovascular system, respiratory system and central nervous system. Monoamine oxidase inhibitors should be discontinued 10 days before the local anesthetic is administered.

Form of production

Solution for injection.

Storage conditions

In a place protected from light, at a temperature not exceeding 20 °C.

Shelf life

3 years

Active ingredient

Procaine

Conditions of release from pharmacies

By prescription

Dosage form

solution for injection

Description

Children as prescribed by a doctor, Nursing mothers as prescribed by a doctor, Children over 12 years of age, Pregnant women as prescribed by a doctor, Adults as prescribed by a doctor

Indications

Anesthesia